Probis-Plus
Generic Name
Folic Acid and Bacillus coagulans
Manufacturer
Drug International Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| probis plus 5 mg tablet | ৳ 10.03 | ৳ 100.30 |
Description
Overview of the medicine
Probis-Plus 5 mg Tablet is a combination of Folic Acid, a B vitamin essential for cell growth and DNA synthesis, and Bacillus coagulans, a probiotic that helps maintain gut flora balance and supports digestive health. It is used to supplement folic acid deficiencies and to support a healthy digestive system.
Uses & Indications
Dosage
Adults
Usually 1 tablet once daily, or as directed by a physician. For specific folic acid deficiency, higher doses may be prescribed.
Elderly
No specific dosage adjustment required; follow adult dosage or as advised by a physician.
Renal_impairment
No specific dosage adjustment recommended for mild to moderate renal impairment. Consult a physician for severe impairment.
How to Take
Take orally, with or without food. Can be taken at any time of day.
Mechanism of Action
Folic Acid acts as a coenzyme in various metabolic processes, including DNA and RNA synthesis, and amino acid metabolism, crucial for cell division and growth. Bacillus coagulans is a spore-forming probiotic that colonizes the intestine, produces lactic acid, and helps restore and maintain a healthy balance of gut microbiota by inhibiting the growth of harmful bacteria and supporting immune function.
Pharmacokinetics
Onset
Folic Acid: Days to weeks for significant effect. Probiotic: Hours to days for symptomatic relief.
Excretion
Folic acid and its metabolites are primarily excreted in the urine. Probiotics are excreted via feces.
Half life
Folic Acid: Approximately several hours (metabolically). Probiotic: No typical pharmacokinetic half-life as they are living organisms.
Absorption
Folic acid is readily absorbed from the gastrointestinal tract, primarily from the jejunum. Probiotic spores survive gastric acidity and germinate in the small intestine.
Metabolism
Folic acid is extensively metabolized in the liver to tetrahydrofolate and other active metabolites. Probiotics are not metabolized in the traditional sense; they colonize and exert their effects locally.
Side Effects
Contraindications
- Hypersensitivity to Folic Acid or any component of the formulation
- Untreated pernicious anemia or other vitamin B12 deficiencies (Folic acid may mask B12 deficiency symptoms)
Drug Interactions
Phenytoin
Folic acid may reduce phenytoin levels, potentially leading to increased seizure activity.
Methotrexate
Folic acid may decrease the efficacy of methotrexate, an antifolate drug.
Tetracyclines
Probiotics should be taken at least 2-3 hours apart from antibiotics like tetracyclines to prevent inactivation.
Storage
Store in a cool, dry place, away from direct sunlight. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose of folic acid is rare and generally considered non-toxic. High doses of probiotics are also well-tolerated. Symptoms might include gastrointestinal upset. Management is symptomatic and supportive.
Pregnancy & Lactation
Generally considered safe and often recommended during pregnancy for neural tube defect prevention. Safe for use during lactation. Consult a physician.
Side Effects
Contraindications
- Hypersensitivity to Folic Acid or any component of the formulation
- Untreated pernicious anemia or other vitamin B12 deficiencies (Folic acid may mask B12 deficiency symptoms)
Drug Interactions
Phenytoin
Folic acid may reduce phenytoin levels, potentially leading to increased seizure activity.
Methotrexate
Folic acid may decrease the efficacy of methotrexate, an antifolate drug.
Tetracyclines
Probiotics should be taken at least 2-3 hours apart from antibiotics like tetracyclines to prevent inactivation.
Storage
Store in a cool, dry place, away from direct sunlight. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose of folic acid is rare and generally considered non-toxic. High doses of probiotics are also well-tolerated. Symptoms might include gastrointestinal upset. Management is symptomatic and supportive.
Pregnancy & Lactation
Generally considered safe and often recommended during pregnancy for neural tube defect prevention. Safe for use during lactation. Consult a physician.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, drugstores
Approval Status
Approved by DGDA
Patent Status
No longer patented
Clinical Trials
Extensive clinical trials support the efficacy and safety of folic acid and various probiotic strains individually and in combinations for their respective indications.
Lab Monitoring
- Serum folate levels (if deficiency is suspected)
- Vitamin B12 levels (to rule out deficiency, as folic acid can mask symptoms)
Doctor Notes
- Counsel patients on the importance of ruling out B12 deficiency before initiating high-dose folic acid.
- Emphasize the role of probiotics in gut health but manage expectations regarding immediate symptomatic relief.
- Advise patients about potential drug interactions, especially with anticonvulsants and antibiotics.
Patient Guidelines
- Take the tablet whole with water.
- Do not exceed the recommended dose without medical advice.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Does not typically affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain a balanced diet rich in fruits, vegetables, and whole grains.
- Ensure adequate hydration.
- Limit processed foods and sugary drinks.
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