Procet
Generic Name
Prochlorperazine 10 mg tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| procet 10 mg tablet | ৳ 2.50 | ৳ 25.00 |
Description
Overview of the medicine
Prochlorperazine is a phenothiazine derivative used primarily as an antiemetic for severe nausea and vomiting. It is also used for the short-term management of severe anxiety and psychotic disorders.
Uses & Indications
Dosage
Adults
For nausea/vomiting: 5-10 mg 3-4 times daily. For anxiety: 5 mg 3-4 times daily. For psychosis: 10-25 mg 2-3 times daily, adjusted as needed.
Elderly
Lower doses may be required due to increased sensitivity and slower metabolism. Start with 2.5-5 mg once or twice daily.
Renal_impairment
No specific dose adjustment for mild to moderate impairment; use with caution in severe impairment.
How to Take
Oral. Can be taken with or without food. Swallow the tablet whole with water. Do not crush or chew.
Mechanism of Action
It exerts its antiemetic effect by blocking dopamine D2 receptors in the chemoreceptor trigger zone (CTZ) in the brain. Its antipsychotic action involves blockage of postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain.
Pharmacokinetics
Onset
Antiemetic effect: 30-40 minutes (oral). Antipsychotic effect: days to weeks.
Excretion
Excreted via urine and feces as metabolites.
Half life
Variable, typically 6-8 hours for antiemetic effects; longer for antipsychotic effects (e.g., 20-40 hours for elimination).
Absorption
Well absorbed orally, but undergoes significant first-pass metabolism. Peak plasma concentrations reached within 1-2 hours.
Metabolism
Extensively metabolized in the liver (CYP450 enzymes).
Side Effects
Contraindications
- •Hypersensitivity to prochlorperazine or other phenothiazines
- •Comatose states
- •Severe central nervous system (CNS) depression
- •Bone marrow depression
- •Blood dyscrasias
- •Children under 2 years or weighing less than 9 kg
Drug Interactions
Anticholinergics
Potentiated anticholinergic effects, increased risk of paralytic ileus and heatstroke.
Antihypertensives
Increased risk of orthostatic hypotension.
Dopamine agonists (e.g., levodopa)
Reduced efficacy of dopamine agonists.
CNS depressants (alcohol, sedatives, opioids)
Enhanced sedative effects and respiratory depression.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include severe drowsiness, low blood pressure, muscle rigidity, tremors, unresponsiveness, and extrapyramidal symptoms. Treatment is supportive; gastric lavage, activated charcoal, IV fluids for hypotension, antiparkinsonian drugs for extrapyramidal symptoms.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk. Excreted in breast milk; avoid breastfeeding or discontinue drug due to potential for serious adverse effects in the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date when stored correctly.
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic available (off-patent)
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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