Procet
Generic Name
Cetirizine Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| procet 5 mg syrup | ৳ 20.00 | N/A |
Description
Overview of the medicine
Procet 5 mg syrup is an antihistamine medication containing Cetirizine Hydrochloride. It is primarily used to relieve symptoms of allergic conditions such as hay fever, chronic urticaria, and allergic rhinitis. It works by blocking the action of histamine, a natural substance in the body that causes allergic symptoms.
Uses & Indications
Dosage
Adults
10 mg (10 ml) once daily or 5 mg (5 ml) twice daily.
Elderly
Dosage adjustment may be required in elderly patients with impaired renal function. Usually, 5 mg (5 ml) once daily.
Renal_impairment
Dose adjustment needed. e.g., CrCl 31-50 ml/min, 5 mg (5 ml) once daily; CrCl 11-30 ml/min, 5 mg (5 ml) every other day.
How to Take
Oral administration. Can be taken with or without food.
Mechanism of Action
Cetirizine is a potent and selective peripheral H1-receptor antagonist. It inhibits the histamine-mediated early phase of allergic reaction and also reduces the migration of inflammatory cells and the release of mediators associated with the late phase of the allergic reaction.
Pharmacokinetics
Onset
Within 20-60 minutes.
Excretion
Primarily excreted unchanged in urine.
Half life
Approximately 8-11 hours (adults); may be longer in children and elderly.
Absorption
Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations reached within 1 hour.
Metabolism
Minor hepatic metabolism (approximately 10%).
Side Effects
Contraindications
- Hypersensitivity to cetirizine, hydroxyzine, or any piperazine derivatives.
- Patients with severe renal impairment (creatinine clearance less than 10 ml/min).
- Children under 6 months of age.
Drug Interactions
Ritonavir
Increased plasma cetirizine levels have been reported.
Theophylline
A small decrease in cetirizine clearance has been observed, but dose adjustment is not usually necessary.
Central Nervous System (CNS) depressants
May enhance CNS depression.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms: Somnolence, tachycardia, tremor, headache, urinary retention. Management: Symptomatic and supportive treatment. No specific antidote. Gastric lavage and activated charcoal may be considered if ingestion is recent.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy should only be considered if clearly needed. Cetirizine is excreted in breast milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to cetirizine, hydroxyzine, or any piperazine derivatives.
- Patients with severe renal impairment (creatinine clearance less than 10 ml/min).
- Children under 6 months of age.
Drug Interactions
Ritonavir
Increased plasma cetirizine levels have been reported.
Theophylline
A small decrease in cetirizine clearance has been observed, but dose adjustment is not usually necessary.
Central Nervous System (CNS) depressants
May enhance CNS depression.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms: Somnolence, tachycardia, tremor, headache, urinary retention. Management: Symptomatic and supportive treatment. No specific antidote. Gastric lavage and activated charcoal may be considered if ingestion is recent.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy should only be considered if clearly needed. Cetirizine is excreted in breast milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of cetirizine in various allergic conditions.
Lab Monitoring
- No routine lab monitoring is generally required.
- Liver function tests may be considered in patients with pre-existing hepatic impairment if prolonged use.
- Renal function should be assessed in patients with renal impairment to adjust dosage.
Doctor Notes
- Advise patients about potential drowsiness, especially when initiating therapy or increasing dosage.
- Consider renal function when prescribing to elderly patients or those with kidney impairment.
- Educate patients on proper measurement and administration of syrup, especially for pediatric use.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Avoid alcohol consumption as it may increase drowsiness.
- Inform your doctor if symptoms do not improve or worsen.
- Store in a cool, dry place away from direct sunlight.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
May cause drowsiness or dizziness. Patients should be advised to exercise caution when driving or operating machinery until they know how they react to the medication.
Lifestyle Advice
- Identify and avoid known allergens where possible.
- Maintain good personal hygiene.
- Stay hydrated by drinking plenty of water.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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