Oral administration. Can be taken with or without food.

Cetirizine is a potent and selective peripheral H1-receptor antagonist. It inhibits the histamine-mediated early phase of allergic reaction and also reduces the migration of inflammatory cells and the release of mediators associated with the late phase of the allergic reaction.

• •Hypersensitivity to cetirizine, hydroxyzine, or any piperazine derivatives.
• •Patients with severe renal impairment (creatinine clearance less than 10 ml/min).
• •Children under 6 months of age.

Store below 30°C in a dry place, away from light. Keep out of reach of children.

Symptoms: Somnolence, tachycardia, tremor, headache, urinary retention. Management: Symptomatic and supportive treatment. No specific antidote. Gastric lavage and activated charcoal may be considered if ingestion is recent.

Pregnancy Category B. Use during pregnancy should only be considered if clearly needed. Cetirizine is excreted in breast milk; caution should be exercised when administered to a nursing woman.