Swallow whole with food or milk to minimize gastrointestinal upset. Do not crush, chew, or divide the capsule.

Ketoprofen inhibits cyclooxygenase (COX-1 and COX-2) enzymes, which are responsible for the synthesis of prostaglandins, mediators of inflammation, pain, and fever.

• •Hypersensitivity to ketoprofen or other NSAIDs (e.g., aspirin)
• •History of gastrointestinal bleeding or peptic ulcer disease
• •Severe renal or hepatic impairment
• •Severe heart failure
• •Third trimester of pregnancy
• •Coronary artery bypass graft (CABG) surgery (peri-operative pain)

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

Symptoms include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Rarely, hypertension, acute renal failure, respiratory depression, and coma may occur. Management is supportive, including gastric lavage or activated charcoal within one hour of ingestion, and treatment of symptoms.

Avoid in the third trimester of pregnancy due to risk of premature closure of the ductus arteriosus and renal dysfunction in the fetus. Use with caution in the first and second trimesters only if clearly needed and benefits outweigh risks. Avoid during breastfeeding as ketoprofen may be excreted in breast milk.