Profenid-CR
Generic Name
Ketoprofen (Extended-Release) 100 mg Capsule
Manufacturer
Sanofi
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| profenid cr 100 mg capsule | ৳ 11.03 | ৳ 110.30 |
Description
Overview of the medicine
Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) used to treat pain, inflammation, and fever. The CR (Controlled-Release) formulation provides sustained release for prolonged effect, allowing for once-daily dosing.
Uses & Indications
Dosage
Adults
100-200 mg once daily (CR formulation). Max 200 mg/day.
Elderly
Lower doses may be required due to increased risk of side effects. Initial dose of 100 mg once daily.
Renal_impairment
Dose adjustment needed; reduced dose or extended intervals. Avoid in severe renal impairment (CrCl < 30 mL/min).
How to Take
Swallow whole with food or milk to minimize gastrointestinal upset. Do not crush, chew, or divide the capsule.
Mechanism of Action
Ketoprofen inhibits cyclooxygenase (COX-1 and COX-2) enzymes, which are responsible for the synthesis of prostaglandins, mediators of inflammation, pain, and fever.
Pharmacokinetics
Onset
Within 1-2 hours for pain relief, but full anti-inflammatory effect may take longer.
Excretion
Primarily renal (kidney) excretion of metabolites and unchanged drug.
Half life
Approximately 2-4 hours, but extended-release formulation prolongs therapeutic effect for 24 hours.
Absorption
Well absorbed orally. Peak plasma levels for CR formulation are typically reached within 4-6 hours.
Metabolism
Primarily hepatic (liver) metabolism via conjugation with glucuronic acid.
Side Effects
Contraindications
- Hypersensitivity to ketoprofen or other NSAIDs (e.g., aspirin)
- History of gastrointestinal bleeding or peptic ulcer disease
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- Coronary artery bypass graft (CABG) surgery (peri-operative pain)
Drug Interactions
Lithium
Increased lithium plasma levels and potential toxicity.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of GI ulceration and bleeding.
Diuretics and ACE inhibitors
Reduced hypotensive effect and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin, Heparin)
Increased risk of bleeding.
Selective Serotonin Reuptake Inhibitors (SSRIs)
Increased risk of GI bleeding.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Rarely, hypertension, acute renal failure, respiratory depression, and coma may occur. Management is supportive, including gastric lavage or activated charcoal within one hour of ingestion, and treatment of symptoms.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy due to risk of premature closure of the ductus arteriosus and renal dysfunction in the fetus. Use with caution in the first and second trimesters only if clearly needed and benefits outweigh risks. Avoid during breastfeeding as ketoprofen may be excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to ketoprofen or other NSAIDs (e.g., aspirin)
- History of gastrointestinal bleeding or peptic ulcer disease
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- Coronary artery bypass graft (CABG) surgery (peri-operative pain)
Drug Interactions
Lithium
Increased lithium plasma levels and potential toxicity.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of GI ulceration and bleeding.
Diuretics and ACE inhibitors
Reduced hypotensive effect and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin, Heparin)
Increased risk of bleeding.
Selective Serotonin Reuptake Inhibitors (SSRIs)
Increased risk of GI bleeding.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Rarely, hypertension, acute renal failure, respiratory depression, and coma may occur. Management is supportive, including gastric lavage or activated charcoal within one hour of ingestion, and treatment of symptoms.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy due to risk of premature closure of the ductus arteriosus and renal dysfunction in the fetus. Use with caution in the first and second trimesters only if clearly needed and benefits outweigh risks. Avoid during breastfeeding as ketoprofen may be excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved (Varies by country)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of ketoprofen for various pain and inflammatory conditions across diverse patient populations. Studies on the CR formulation demonstrate sustained plasma levels and prolonged therapeutic effect.
Lab Monitoring
- Regular monitoring of renal function (serum creatinine, BUN) especially in elderly or patients with pre-existing renal impairment.
- Liver function tests (LFTs) if long-term use or symptoms of hepatic dysfunction occur.
- Complete blood counts (CBC) for signs of anemia or GI bleeding, especially with prolonged use.
Doctor Notes
- Counsel patients on the importance of taking with food to mitigate GI side effects.
- Emphasize the black box warnings regarding cardiovascular and gastrointestinal risks, especially in high-risk patients.
- Advise caution in elderly patients and those with pre-existing renal, hepatic, or cardiac conditions, requiring dose adjustments and close monitoring.
- Review concomitant medications for potential drug interactions, particularly with anticoagulants, corticosteroids, and diuretics.
Patient Guidelines
- Take exactly as prescribed by your doctor; do not alter the dose or duration without consulting.
- Swallow the capsule whole; do not crush, chew, or break it, as this can affect its extended-release properties.
- Take with food or milk to reduce the risk of stomach upset.
- Immediately report any signs of unusual bleeding, severe stomach pain, black/tarry stools, or yellowing of skin/eyes.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue your regular schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Profenid-CR may cause dizziness, drowsiness, or visual disturbances. If you experience these effects, avoid driving or operating machinery until you are sure you can perform such activities safely.
Lifestyle Advice
- Avoid or limit alcohol consumption as it can increase the risk of gastrointestinal bleeding.
- Discuss alternative pain management strategies with your doctor for long-term use, especially if you have cardiovascular or gastrointestinal risks.
- Maintain a healthy lifestyle, including a balanced diet and regular exercise, as advised by your healthcare provider.
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