Profenid-CR
Generic Name
Ketoprofen (Controlled Release)
Manufacturer
Sanofi (original), various generics
Country
France (original manufacturer), various countries for generics
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| profenid cr 200 mg capsule | ৳ 20.06 | ৳ 200.60 |
Description
Overview of the medicine
Profenid-CR 200 mg Capsule is a controlled-release formulation of Ketoprofen, a non-steroidal anti-inflammatory drug (NSAID). It is used to relieve pain, inflammation, and fever associated with various conditions such as arthritis, musculoskeletal pain, and dysmenorrhea.
Uses & Indications
Dosage
Adults
200 mg once daily, preferably with food.
Elderly
Lower effective dose should be used, with careful monitoring for adverse effects.
Renal_impairment
Dose adjustment required based on creatinine clearance; generally reduced dose or avoided in severe impairment.
How to Take
Take orally once daily, preferably with food or milk to minimize gastrointestinal upset. Swallow the capsule whole; do not chew, crush, or break it.
Mechanism of Action
Ketoprofen works by inhibiting the activity of cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2. This inhibition leads to a reduction in the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever.
Pharmacokinetics
Onset
Within 2-4 hours (for CR formulation, sustained effect).
Excretion
Primarily excreted in the urine (about 50-90%) as metabolites, with a small amount in feces.
Half life
Approximately 2-4 hours (for immediate release; CR maintains levels longer).
Absorption
Well absorbed orally. Controlled-release formulation provides sustained absorption.
Metabolism
Extensively metabolized in the liver via glucuronidation.
Side Effects
Contraindications
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Severe heart failure
- History of asthma, urticaria, or allergic reactions after taking aspirin or other NSAIDs
- Third trimester of pregnancy
- Coronary Artery Bypass Graft (CABG) surgery (peri-operative pain)
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding.
Lithium
Increased plasma lithium levels.
Warfarin
Increased risk of bleeding.
Methotrexate
Increased methotrexate toxicity.
Diuretics and ACE inhibitors
Reduced hypotensive effect and increased risk of renal impairment.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric pain, lethargy, and drowsiness. More severe symptoms like GI bleeding, hypertension, acute renal failure, and respiratory depression may occur. Treatment is symptomatic and supportive; there is no specific antidote. Gastric lavage and activated charcoal may be considered if ingested recently.
Pregnancy & Lactation
Pregnancy category C; avoid in the third trimester due to potential premature closure of the ductus arteriosus and renal dysfunction in the fetus. Use with caution in the first and second trimesters only if the potential benefit outweighs the risk. Not recommended during breastfeeding as ketoprofen may pass into breast milk.
Side Effects
Contraindications
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Severe heart failure
- History of asthma, urticaria, or allergic reactions after taking aspirin or other NSAIDs
- Third trimester of pregnancy
- Coronary Artery Bypass Graft (CABG) surgery (peri-operative pain)
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding.
Lithium
Increased plasma lithium levels.
Warfarin
Increased risk of bleeding.
Methotrexate
Increased methotrexate toxicity.
Diuretics and ACE inhibitors
Reduced hypotensive effect and increased risk of renal impairment.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric pain, lethargy, and drowsiness. More severe symptoms like GI bleeding, hypertension, acute renal failure, and respiratory depression may occur. Treatment is symptomatic and supportive; there is no specific antidote. Gastric lavage and activated charcoal may be considered if ingested recently.
Pregnancy & Lactation
Pregnancy category C; avoid in the third trimester due to potential premature closure of the ductus arteriosus and renal dysfunction in the fetus. Use with caution in the first and second trimesters only if the potential benefit outweighs the risk. Not recommended during breastfeeding as ketoprofen may pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by drug regulatory authorities (e.g., FDA, DGDA)
Patent Status
Patent expired for generic ketoprofen, brand Profenid-CR may have brand-specific protections.
Clinical Trials
Ketoprofen has been extensively studied in various clinical trials demonstrating its efficacy in pain and inflammation management. Controlled-release formulations are designed to improve patient compliance and reduce dosing frequency.
Lab Monitoring
- Complete Blood Count (CBC)
- Renal function tests (creatinine, BUN)
- Liver function tests (ALT, AST)
- Blood pressure monitoring
Doctor Notes
- Consider lowest effective dose for shortest duration possible, especially in elderly and patients with cardiovascular or GI risk factors.
- Monitor renal function, liver function, and blood pressure periodically during long-term therapy.
- Educate patients on GI bleeding symptoms and cardiovascular risks.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor.
- Always take with food or milk to minimize stomach upset.
- Do not chew, crush, or break the controlled-release capsule; swallow it whole.
- Do not take more than the recommended dose.
- Report any signs of unusual bleeding, black or tarry stools, or persistent stomach pain to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness, drowsiness, or visual disturbances. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Avoid or limit alcohol consumption during treatment.
- Avoid smoking, as it may exacerbate gastrointestinal risks.
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