Progan
Generic Name
Promethazine
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| progan 5 mg oral solution | ৳ 23.95 | N/A |
Description
Overview of the medicine
Progan (Promethazine) is a first-generation antihistamine with strong sedative and antiemetic properties. It is used to treat allergic reactions, motion sickness, and as a short-term sedative.
Uses & Indications
Dosage
Adults
Allergy: 10-25 mg at bedtime or 10-25 mg 2-3 times daily. Motion Sickness: 25 mg 30-60 min before travel, then 25 mg every 8-12 hours as needed. Sedation: 25-50 mg at night.
Elderly
Lower doses (e.g., 10-15 mg) may be required due to increased sensitivity to side effects.
Renal_impairment
Use with caution; dose reduction may be necessary in severe impairment.
How to Take
Can be taken with or without food. Syrup can be measured with a dosing spoon/cup. Tablets should be swallowed whole.
Mechanism of Action
Promethazine acts as an H1 receptor antagonist, blocking histamine's effects. It also has anticholinergic, antidopaminergic, and alpha-adrenergic blocking properties, contributing to its sedative and antiemetic effects.
Pharmacokinetics
Onset
Oral: 20-60 minutes
Excretion
Excreted mainly via urine as metabolites; some via feces.
Half life
Approximately 10-14 hours (variable, 7-12 hours in some sources)
Absorption
Well absorbed from the gastrointestinal tract.
Metabolism
Extensively metabolized in the liver (primarily by hydroxylation and N-demethylation).
Side Effects
Contraindications
- Children under 2 years of age (risk of respiratory depression)
- Comatose states
- Severe CNS depression
- Hypersensitivity to promethazine or other phenothiazines
- Patients taking MAO inhibitors
Drug Interactions
Epinephrine
Promethazine may reverse the pressor effect of epinephrine.
MAO Inhibitors
Enhanced and prolonged anticholinergic effects of promethazine.
Anticholinergics
Increased anticholinergic side effects (e.g., dry mouth, blurred vision, constipation).
CNS Depressants (e.g., alcohol, opioids, benzodiazepines)
Increased sedation and respiratory depression.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include severe drowsiness, confusion, loss of coordination, seizures, respiratory depression, and coma. Treatment is symptomatic and supportive, including maintaining airway, assisting ventilation, and managing seizures.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Not recommended during breastfeeding as it can pass into breast milk and cause sedation in the infant.
Side Effects
Contraindications
- Children under 2 years of age (risk of respiratory depression)
- Comatose states
- Severe CNS depression
- Hypersensitivity to promethazine or other phenothiazines
- Patients taking MAO inhibitors
Drug Interactions
Epinephrine
Promethazine may reverse the pressor effect of epinephrine.
MAO Inhibitors
Enhanced and prolonged anticholinergic effects of promethazine.
Anticholinergics
Increased anticholinergic side effects (e.g., dry mouth, blurred vision, constipation).
CNS Depressants (e.g., alcohol, opioids, benzodiazepines)
Increased sedation and respiratory depression.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include severe drowsiness, confusion, loss of coordination, seizures, respiratory depression, and coma. Treatment is symptomatic and supportive, including maintaining airway, assisting ventilation, and managing seizures.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Not recommended during breastfeeding as it can pass into breast milk and cause sedation in the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, Hospitals (Bangladesh)
Approval Status
Approved by DGDA
Patent Status
Generic (Off-patent)
WHO Essential Medicine
YesClinical Trials
Promethazine has been extensively studied since its introduction. Current research focuses on its role in combination therapies and specific patient populations.
Lab Monitoring
- Liver function tests (with long-term use)
- Complete blood count (CBC) if blood dyscrasias are suspected
Doctor Notes
- Exercise caution when prescribing to elderly patients due to increased susceptibility to anticholinergic and sedative effects.
- Monitor for signs of respiratory depression, especially in children and those with pre-existing respiratory conditions.
- Advise patients about potential for photosensitivity.
Patient Guidelines
- Avoid driving or operating machinery until you know how this medicine affects you.
- Avoid alcohol while taking Progan.
- Report any unusual muscle movements or fever to your doctor immediately.
- Do not use in children under 2 years of age.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause significant drowsiness and impaired judgment. Avoid driving or operating heavy machinery.
Lifestyle Advice
- Ensure adequate hydration to manage dry mouth.
- Avoid excessive sun exposure due to photosensitivity.
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