Prosalic
Generic Name
Clobetasol Propionate + Salicylic Acid
Manufacturer
Many manufacturers (e.g., Square Pharmaceuticals, Renata Limited, Beximco Pharmaceuticals in BD)
Country
Bangladesh (for local brands), various (for original generic)
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| prosalic 005 2 scalp lotion | ৳ 150.45 | N/A |
Description
Overview of the medicine
Prosalic is a topical corticosteroid preparation containing Clobetasol Propionate and Salicylic Acid, used for treating various inflammatory and hyperkeratotic dermatological conditions such as psoriasis and eczema.
Uses & Indications
Dosage
Adults
Apply a thin layer to the affected skin areas once or twice daily. Do not exceed 50g per week. Treatment should be limited to 2 weeks consecutively. Re-evaluate if no improvement.
Elderly
No specific dose adjustment, but caution due to potentially thinner skin and increased systemic absorption.
Renal_impairment
No specific dose adjustment for topical use.
How to Take
For external use only. Apply a thin film to the affected skin area and gently rub in. Wash hands thoroughly before and after application. Avoid contact with eyes, face, and mucous membranes.
Mechanism of Action
Clobetasol Propionate is a high-potency corticosteroid that reduces inflammation, pruritus, and vasoconstriction. Salicylic Acid is a keratolytic agent that aids in shedding of the outer layer of skin, reducing scaling and facilitating corticosteroid penetration.
Pharmacokinetics
Onset
Within a few days for symptomatic relief.
Excretion
Mainly via urine for both components if systemically absorbed.
Half life
Clobetasol has a plasma half-life of about 3-5 hours. Salicylic acid: variable, dependent on dosage form and application area.
Absorption
Minimal systemic absorption, but can increase with prolonged use, large surface areas, or occlusive dressings. Salicylic acid can be absorbed systemically.
Metabolism
Primarily hepatic metabolism for both components if significant systemic absorption occurs.
Side Effects
Contraindications
- Hypersensitivity to Clobetasol Propionate, Salicylic Acid, or any excipients
- Viral infections (e.g., herpes simplex, chickenpox)
- Fungal infections
- Bacterial infections
- Perioral dermatitis
- Acne vulgaris
- Rosacea
- Children under 12 years of age
- Application to large areas or broken skin
Drug Interactions
Other Keratolytics
Potentially increased systemic absorption of Salicylic Acid with concurrent use of other keratolytic agents.
No significant systemic drug interactions expected with proper topical use.
No significant systemic drug interactions expected with proper topical use.
Storage
Store below 30°C in a dry place, away from direct sunlight. Keep out of reach of children.
Overdose
Topical overdose is unlikely to produce acute systemic effects. However, prolonged excessive use may lead to systemic corticosteroid effects. Discontinue use and manage symptomatically.
Pregnancy & Lactation
Use with caution during pregnancy and lactation only if the potential benefit outweighs the potential risk to the fetus/infant. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Clobetasol Propionate, Salicylic Acid, or any excipients
- Viral infections (e.g., herpes simplex, chickenpox)
- Fungal infections
- Bacterial infections
- Perioral dermatitis
- Acne vulgaris
- Rosacea
- Children under 12 years of age
- Application to large areas or broken skin
Drug Interactions
Other Keratolytics
Potentially increased systemic absorption of Salicylic Acid with concurrent use of other keratolytic agents.
No significant systemic drug interactions expected with proper topical use.
No significant systemic drug interactions expected with proper topical use.
Storage
Store below 30°C in a dry place, away from direct sunlight. Keep out of reach of children.
Overdose
Topical overdose is unlikely to produce acute systemic effects. However, prolonged excessive use may lead to systemic corticosteroid effects. Discontinue use and manage symptomatically.
Pregnancy & Lactation
Use with caution during pregnancy and lactation only if the potential benefit outweighs the potential risk to the fetus/infant. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Off-patent
Clinical Trials
Extensive clinical data available for individual components and combinations in various dermatological conditions.
Lab Monitoring
- No routine lab monitoring required for typical topical use. In cases of extensive or prolonged use, monitoring for systemic corticosteroid effects (e.g., plasma cortisol levels, blood glucose) may be considered.
Doctor Notes
- Emphasize limited duration of use and avoidance on sensitive areas.
- Educate patients on signs of skin thinning and infection.
- Consider alternative treatments for long-term management of chronic conditions.
- Regular follow-up is important.
Patient Guidelines
- Use exactly as prescribed by your doctor.
- Do not use for longer than 2 weeks without medical advice.
- Avoid applying to the face, groin, or armpits unless specifically directed.
- Do not cover the treated area with occlusive dressings unless advised by a doctor.
- Report any worsening skin condition or new side effects to your doctor.
Missed Dose Advice
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply a double dose.
Driving Precautions
Prosalic is a topical medication and is not expected to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain good skin hygiene.
- Avoid irritants that can worsen skin conditions.
- Moisturize skin regularly if prone to dryness.
- Avoid scratching affected areas to prevent infection.
- Wear loose, breathable clothing.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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