Proxid
Generic Name
Pantoprazole
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| proxid 6 mg tablet | ৳ 2.50 | N/A |
Description
Overview of the medicine
Proxid (Pantoprazole) is a proton pump inhibitor (PPI) that decreases the amount of acid produced in the stomach. It is used to treat conditions such as acid reflux, ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
For GERD and erosive esophagitis: 40 mg once daily for up to 8 weeks. For Zollinger-Ellison Syndrome: Initially 40 mg twice daily, adjusted as needed.
Elderly
No specific dose adjustment is generally required, but close monitoring is advisable.
Renal_impairment
No dose adjustment is necessary for patients with renal impairment.
How to Take
Take orally before a meal, preferably in the morning. Swallow the tablet whole; do not chew or crush.
Mechanism of Action
Pantoprazole binds irreversibly to the H+/K+ ATPase enzyme (the proton pump) on the secretory surface of the gastric parietal cells. This inhibits the final step in gastric acid production, leading to a sustained decrease in acid secretion.
Pharmacokinetics
Onset
Onset of acid suppression within 2-3 hours.
Excretion
Primarily excreted renally (approximately 80%) and via biliary/fecal route (approximately 20%).
Half life
The plasma elimination half-life is approximately 1 hour.
Absorption
Rapidly absorbed after oral administration; bioavailability is approximately 77%. Peak plasma concentrations occur 2-2.5 hours after an oral dose.
Metabolism
Extensively metabolized in the liver primarily by CYP2C19 and to a lesser extent by CYP3A4.
Side Effects
Contraindications
- Known hypersensitivity to Pantoprazole or any component of the formulation
- Concurrent use with atazanavir or nelfinavir
Drug Interactions
Warfarin
May increase INR and prothrombin time, monitor for bleeding.
Methotrexate
May increase methotrexate levels, especially with high doses.
Atazanavir/Nelfinavir
Significantly reduces absorption and efficacy of these antiretrovirals, co-administration is contraindicated.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
There is no known specific antidote for Pantoprazole overdose. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in breast milk, use with caution during lactation.
Side Effects
Contraindications
- Known hypersensitivity to Pantoprazole or any component of the formulation
- Concurrent use with atazanavir or nelfinavir
Drug Interactions
Warfarin
May increase INR and prothrombin time, monitor for bleeding.
Methotrexate
May increase methotrexate levels, especially with high doses.
Atazanavir/Nelfinavir
Significantly reduces absorption and efficacy of these antiretrovirals, co-administration is contraindicated.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
There is no known specific antidote for Pantoprazole overdose. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in breast milk, use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA
Patent Status
Off-patent (Generic available)
WHO Essential Medicine
YesClinical Trials
Pantoprazole has undergone extensive clinical trials demonstrating its efficacy and safety for various acid-related disorders. Bioequivalence studies are typically conducted for generic versions.
Lab Monitoring
- Magnesium levels (especially with long-term use or concomitant diuretics)
- Vitamin B12 levels (with prolonged therapy)
Doctor Notes
- Consider the lowest effective dose for the shortest duration necessary.
- Periodically reassess the need for continued PPI therapy, especially for maintenance treatment.
- Advise patients on lifestyle modifications to complement therapy.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not crush, chew, or break the tablet.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Proxid may cause dizziness in some individuals. If you experience dizziness, avoid driving or operating machinery.
Lifestyle Advice
- Avoid spicy, fatty, and acidic foods that may worsen symptoms.
- Elevate the head of your bed while sleeping.
- Avoid eating large meals close to bedtime.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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