Prucon
Generic Name
Prucalopride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| prucon 1 mg tablet | ৳ 13.00 | ৳ 130.00 |
| prucon 2 mg tablet | ৳ 24.00 | ৳ 240.00 |
Description
Overview of the medicine
Prucon is a medication containing Prucalopride, used for the symptomatic treatment of chronic constipation in adults when laxatives fail to provide adequate relief. It works by stimulating colonic motility.
Uses & Indications
Dosage
Adults
1 mg once daily. If needed and tolerated, the dose can be increased to 2 mg once daily.
Elderly
Start with 1 mg once daily. Consider increasing to 2 mg if necessary and tolerated.
Renal_impairment
For severe renal impairment (CrCl < 30 mL/min), 1 mg once daily. No dosage adjustment needed for mild to moderate renal impairment.
How to Take
Prucon tablets can be taken with or without food, at any time of the day. Swallow the tablet whole with water.
Mechanism of Action
Prucalopride is a selective, high-affinity 5-HT4 receptor agonist that stimulates colonic motility, leading to increased bowel movements and relief from chronic constipation. It promotes propulsive motility in the colon.
Pharmacokinetics
Onset
Onset of action within 24 hours for some patients, full effect may take 1-2 weeks.
Excretion
Mainly excreted unchanged in urine (about 60-65%) and feces (about 25-30%).
Half life
Approximately 24-28 hours.
Absorption
Rapidly absorbed after oral administration, peak plasma concentration reached in 2-3 hours. Bioavailability is >90%.
Metabolism
Minimal hepatic metabolism; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to prucalopride or any of the excipients.
- Intestinal obstruction, intestinal perforation, or other inflammatory bowel conditions (e.g., Crohn's disease, ulcerative colitis, toxic megacolon/megarectum).
- Severe renal impairment requiring dialysis.
Drug Interactions
Rifampicin
May decrease prucalopride plasma levels due to CYP3A4 induction.
Ketoconazole, Erythromycin, Clarithromycin
May increase prucalopride plasma levels due to CYP3A4 inhibition, but generally not clinically significant.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive measures should be taken. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Prucon should not be used during pregnancy unless clearly necessary. It is excreted into breast milk; therefore, use is not recommended during breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to prucalopride or any of the excipients.
- Intestinal obstruction, intestinal perforation, or other inflammatory bowel conditions (e.g., Crohn's disease, ulcerative colitis, toxic megacolon/megarectum).
- Severe renal impairment requiring dialysis.
Drug Interactions
Rifampicin
May decrease prucalopride plasma levels due to CYP3A4 induction.
Ketoconazole, Erythromycin, Clarithromycin
May increase prucalopride plasma levels due to CYP3A4 inhibition, but generally not clinically significant.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive measures should be taken. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Prucon should not be used during pregnancy unless clearly necessary. It is excreted into breast milk; therefore, use is not recommended during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Available in pharmacies and hospitals nationwide
Approval Status
Approved by DGDA, US FDA, EMA
Patent Status
Patent protected (originator), generics available
Clinical Trials
Prucalopride has undergone several phase III clinical trials demonstrating its efficacy and safety in treating chronic idiopathic constipation.
Lab Monitoring
- Routine laboratory monitoring is generally not required.
Doctor Notes
- Assess for underlying causes of constipation before initiating Prucon.
- Monitor patient response and adjust dose if necessary.
- Advise patients on lifestyle modifications alongside medication.
Patient Guidelines
- Take Prucon exactly as prescribed by your doctor.
- Maintain adequate fluid intake while on this medication.
- Inform your doctor if your constipation does not improve after 4 weeks of treatment.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Prucon has no or negligible influence on the ability to drive and use machines. However, if dizziness or fatigue occurs, caution is advised.
Lifestyle Advice
- Include fiber-rich foods in your diet.
- Drink plenty of water throughout the day.
- Engage in regular physical activity to promote bowel regularity.
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