Prupride
Generic Name
Prucalopride 1 mg tablet
Manufacturer
ACI Limited
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| prupride 1 mg tablet | ৳ 14.00 | ৳ 140.00 |
Description
Overview of the medicine
Prucalopride is a selective, high-affinity 5-hydroxytryptamine (5-HT4) receptor agonist indicated for the symptomatic treatment of chronic idiopathic constipation in adults for whom laxatives fail to provide adequate relief.
Uses & Indications
Dosage
Adults
The recommended dose is 2 mg once daily. For some patients, 1 mg once daily may be sufficient, especially if tolerability is an issue. Dosage should not exceed 2 mg/day.
Elderly
No specific dose adjustment is required based on age alone. However, caution should be exercised in elderly patients with concomitant renal impairment.
Renal_impairment
For patients with severe renal impairment (creatinine clearance < 30 mL/min), the dose is 1 mg once daily. No dose adjustment is needed for mild to moderate renal impairment.
How to Take
Prucalopride tablets should be taken orally, with or without food, at any time of day. Swallow the tablet whole with water.
Mechanism of Action
Prucalopride selectively stimulates 5-HT4 receptors in the gastrointestinal tract, leading to increased colon motility and bowel movements, thereby facilitating stool transit.
Pharmacokinetics
Onset
Clinical effects (improved bowel movements) typically observed within 1-2 weeks of treatment initiation.
Excretion
Primarily renal excretion (approximately 60-65% unchanged in urine), with some fecal excretion (approximately 20%).
Half life
Approximately 24-30 hours, allowing for once-daily dosing.
Absorption
Rapidly absorbed after oral administration, peak plasma concentration (Cmax) achieved within 2-3 hours. Oral bioavailability is high (approximately 90%).
Metabolism
Minimally metabolized; approximately 60% of the dose is excreted unchanged in urine. No significant CYP450 metabolism.
Side Effects
Contraindications
- •Hypersensitivity to the active substance or to any of the excipients.
- •Intestinal perforation or obstruction, severe inflammatory conditions of the intestinal tract such as Crohn's disease, ulcerative colitis, and toxic megacolon/megarectum.
Drug Interactions
Anticholinergics
May reduce the effect of prucalopride as they inhibit gastrointestinal motility.
Other 5-HT4 agonists
Coadministration is not recommended as prucalopride is a selective 5-HT4 agonist and additive effects are possible.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include headache, nausea, and diarrhea. Management is symptomatic and supportive. No specific antidote is available.
Pregnancy & Lactation
Prucalopride is not recommended during pregnancy. Women of childbearing potential should use effective contraception. It is excreted into human milk, so breastfeeding is not recommended during treatment.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent/Generic available
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
More Medicines
Explore other medicines you might be interested in
