Medicine Information

Prupride

Name: Prupride
Brand: Prupride
Rating: 4.5 (117 reviews)

Tablet1 mgProkinetic agentsATC: A06AX05

Generic Name

Prucalopride 1 mg tablet

Manufacturer

ACI Limited

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
prupride 1 mg tablet	৳ 14.00 ((3 x 10: ৳ 420.00))	৳ 140.00

Description

Overview of the medicine

Prucalopride is a selective, high-affinity 5-hydroxytryptamine (5-HT4) receptor agonist indicated for the symptomatic treatment of chronic idiopathic constipation in adults for whom laxatives fail to provide adequate relief.

Uses & Indications

Symptomatic treatment of chronic idiopathic constipation in adults for whom laxatives fail to provide adequate relief.

Dosage

Adults

The recommended dose is 2 mg once daily. For some patients, 1 mg once daily may be sufficient, especially if tolerability is an issue. Dosage should not exceed 2 mg/day.

Elderly

No specific dose adjustment is required based on age alone. However, caution should be exercised in elderly patients with concomitant renal impairment.

Renal_impairment

For patients with severe renal impairment (creatinine clearance < 30 mL/min), the dose is 1 mg once daily. No dose adjustment is needed for mild to moderate renal impairment.

How to Take

Prucalopride tablets should be taken orally, with or without food, at any time of day. Swallow the tablet whole with water.

Mechanism of Action

Prucalopride selectively stimulates 5-HT4 receptors in the gastrointestinal tract, leading to increased colon motility and bowel movements, thereby facilitating stool transit.

Pharmacokinetics

Onset

Clinical effects (improved bowel movements) typically observed within 1-2 weeks of treatment initiation.

Excretion

Primarily renal excretion (approximately 60-65% unchanged in urine), with some fecal excretion (approximately 20%).

Half life

Approximately 24-30 hours, allowing for once-daily dosing.

Absorption

Rapidly absorbed after oral administration, peak plasma concentration (Cmax) achieved within 2-3 hours. Oral bioavailability is high (approximately 90%).

Metabolism

Minimally metabolized; approximately 60% of the dose is excreted unchanged in urine. No significant CYP450 metabolism.

Side Effects

Contraindications

Hypersensitivity to the active substance or to any of the excipients.
Intestinal perforation or obstruction, severe inflammatory conditions of the intestinal tract such as Crohn's disease, ulcerative colitis, and toxic megacolon/megarectum.

Drug Interactions

Anticholinergics

May reduce the effect of prucalopride as they inhibit gastrointestinal motility.

Other 5-HT4 agonists

Coadministration is not recommended as prucalopride is a selective 5-HT4 agonist and additive effects are possible.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include headache, nausea, and diarrhea. Management is symptomatic and supportive. No specific antidote is available.

Pregnancy & Lactation

Prucalopride is not recommended during pregnancy. Women of childbearing potential should use effective contraception. It is excreted into human milk, so breastfeeding is not recommended during treatment.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets20 tablets

Shelf Life

24 to 36 months from manufacturing date.

Availability

Pharmacies, Hospitals

Approval Status

Approved

Patent Status

Off-patent/Generic available

Clinical Trials

Extensive clinical trials have demonstrated the efficacy and safety of prucalopride in adult patients with chronic idiopathic constipation over periods up to 12 weeks and beyond.

Lab Monitoring

No specific routine lab monitoring is required. Liver function tests may be considered in patients with pre-existing hepatic impairment.

Doctor Notes

Assess patient response to treatment after 4 weeks; if no benefit, consider re-evaluation of the diagnosis.
Dose adjustment required for severe renal impairment (CrCl < 30 mL/min).
Caution in patients with a history of serious cardiovascular disease.

Patient Guidelines

Take the medicine exactly as prescribed by your doctor.
Do not exceed the recommended dose.
Inform your doctor if your constipation does not improve after 4 weeks of treatment.
Report any severe or persistent side effects to your doctor.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Prucalopride may cause dizziness and fatigue, especially during the first few days of treatment. Patients should be advised not to drive or operate machinery until they know how the medicine affects them.