Pulmidone
Generic Name
Pulmodexone
Manufacturer
MediCorp Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| pulmidone 801 mg tablet | ৳ 125.00 | ৳ 1,250.00 |
Description
Overview of the medicine
Pulmidone 801 mg Tablet is a synthetic corticosteroid (Pulmodexone) used for its potent anti-inflammatory and immunosuppressive effects. It helps reduce inflammation and swelling in various conditions.
Uses & Indications
Dosage
Adults
Initially 801 mg once daily, adjusted based on response. Max 1602 mg/day.
Elderly
No specific dosage adjustment usually required, but monitor for adverse effects.
Renal_impairment
No dosage adjustment needed for mild to moderate impairment. Use with caution in severe renal impairment.
How to Take
Take orally with food to minimize gastrointestinal upset. Do not crush or chew the tablet.
Mechanism of Action
Pulmodexone acts by binding to glucocorticoid receptors, thereby altering gene expression. This leads to the inhibition of inflammatory mediators (e.g., prostaglandins, leukotrienes) and suppression of immune responses.
Pharmacokinetics
Onset
Within 1-2 hours for anti-inflammatory effects.
Excretion
Mainly via urine as metabolites, minor fecal excretion.
Half life
Approximately 3-4 hours.
Absorption
Rapidly and extensively absorbed from the gastrointestinal tract.
Metabolism
Primarily hepatic, via CYP3A4.
Side Effects
Contraindications
- Systemic fungal infections
- Hypersensitivity to Pulmodexone or any component
- Live virus vaccinations during treatment
Drug Interactions
Ketoconazole
Increases plasma concentration of Pulmidone due to CYP3A4 inhibition.
Phenobarbital
Decreases plasma concentration of Pulmidone due to CYP3A4 induction.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include increased adverse effects. Treatment is symptomatic and supportive. Gastric lavage may be considered soon after ingestion.
Pregnancy & Lactation
Category C for pregnancy. Use only if potential benefit outweighs risk. Excreted in breast milk; caution advised.
Side Effects
Contraindications
- Systemic fungal infections
- Hypersensitivity to Pulmodexone or any component
- Live virus vaccinations during treatment
Drug Interactions
Ketoconazole
Increases plasma concentration of Pulmidone due to CYP3A4 inhibition.
Phenobarbital
Decreases plasma concentration of Pulmidone due to CYP3A4 induction.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include increased adverse effects. Treatment is symptomatic and supportive. Gastric lavage may be considered soon after ingestion.
Pregnancy & Lactation
Category C for pregnancy. Use only if potential benefit outweighs risk. Excreted in breast milk; caution advised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent pending
Clinical Trials
Phase III trials demonstrated significant efficacy in reducing inflammation and improving respiratory function in patients with chronic respiratory conditions. Further studies are ongoing.
Lab Monitoring
- Blood glucose levels
- Electrolyte levels
- Bone mineral density (long-term use)
- Adrenal function tests
Doctor Notes
- Advise patients on gradual tapering to avoid adrenal crisis.
- Monitor patients for signs of infection and metabolic disturbances, including blood glucose and electrolyte levels.
- Consider bone protection strategies (e.g., calcium/vitamin D supplementation) for long-term use, especially in high-risk patients.
Patient Guidelines
- Do not stop taking this medicine abruptly without consulting your doctor.
- Report any signs of infection or unusual weight gain.
- Carry a steroid warning card if on long-term therapy.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and resume your regular schedule. Do not double the dose.
Driving Precautions
Pulmidone is not expected to affect the ability to drive or operate machinery. However, if you experience dizziness or visual disturbances, avoid such activities.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and vitamin D.
- Regular exercise may help mitigate bone density loss.
- Avoid exposure to people with infections, especially chickenpox or measles.
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