Pulmosis
Generic Name
Pulmosin
Manufacturer
Global Pharma Inc.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| pulmosis 267 mg capsule | ৳ 45.00 | ৳ 450.00 |
Description
Overview of the medicine
Pulmosis 267 mg capsule contains Pulmosin, a selective phosphodiesterase-4 (PDE4) inhibitor, used for the treatment of moderate to severe chronic obstructive pulmonary disease (COPD) to reduce the risk of exacerbations.
Uses & Indications
Dosage
Adults
One 267 mg capsule orally once daily.
Elderly
No dose adjustment is required in elderly patients.
Renal_impairment
No dose adjustment is required for patients with mild to moderate renal impairment. Use with caution in severe renal impairment.
How to Take
Pulmosis capsule should be taken orally with water, with or without food, at the same time each day.
Mechanism of Action
Pulmosin works by selectively inhibiting phosphodiesterase-4 (PDE4), an enzyme found in inflammatory cells. This inhibition leads to an increase in intracellular cyclic AMP (cAMP) levels, which in turn reduces inflammation and relaxes smooth muscles in the airways, thereby improving lung function and reducing COPD exacerbations.
Pharmacokinetics
Onset
Clinical effects may be observed within 2-4 weeks of continuous use.
Excretion
Excreted mainly via urine (70%) and feces (20%) as metabolites.
Half life
Approximately 15-20 hours for Pulmosin and its active metabolite.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations reached within 2-4 hours.
Metabolism
Extensively metabolized in the liver, primarily via CYP3A4 and CYP1A2, into an active N-oxide metabolite.
Side Effects
Contraindications
- •Hypersensitivity to Pulmosin or any component of the formulation.
- •Moderate to severe liver impairment.
- •Patients with acute unstable cardiac conditions.
- •History of depression associated with suicidal ideation.
Drug Interactions
Theophylline
Concomitant use with Pulmosin is not recommended due to increased risk of side effects.
Strong CYP1A2 inhibitors (e.g., Fluvoxamine)
May increase Pulmosin exposure, potentially increasing side effects. Dose adjustment may be necessary.
Strong CYP3A4 inducers (e.g., Rifampicin, Phenobarbital)
May significantly decrease Pulmosin exposure, reducing efficacy. Co-administration is not recommended.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe nausea, vomiting, diarrhea, abdominal pain, and headache. In case of overdose, symptomatic and supportive measures should be initiated. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown whether Pulmosin is excreted in human milk. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Available in all registered pharmacies
Approval Status
Approved by DGDA and major international health authorities
Patent Status
Under patent (expires 2035)
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Global Brand Names
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