Quiet
Generic Name
Sedationin Hydrochloride
Manufacturer
Fictional Pharma Inc.
Country
USA
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| quiet 100 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Quiet 100 mg Tablet is a sedative-hypnotic medication used for the short-term treatment of insomnia and anxiety disorders. It helps to calm the brain and induce sleep.
Uses & Indications
Dosage
Adults
Initial dose: 100 mg orally once daily at bedtime for insomnia. For anxiety: 50 mg two to three times daily. Max 300 mg/day.
Elderly
Initial dose: 50 mg orally once daily at bedtime, or 25 mg two times daily for anxiety. Adjust based on response and tolerability.
Renal_impairment
No dose adjustment typically required for mild to moderate impairment. Use with caution in severe impairment.
How to Take
Take orally with water, preferably on an empty stomach for faster absorption. For insomnia, take immediately before going to bed. Do not crush or chew.
Mechanism of Action
Quiet acts by binding to specific GABA-A receptor subunits in the brain, enhancing the effects of GABA, an inhibitory neurotransmitter. This leads to reduced neuronal excitability, producing sedative, hypnotic, anxiolytic, and anticonvulsant effects.
Pharmacokinetics
Onset
15-30 minutes
Excretion
Mainly excreted in urine (approx. 60%) and feces (approx. 40%) as metabolites.
Half life
2.5-4 hours
Absorption
Rapidly absorbed from the gastrointestinal tract, reaching peak plasma concentrations within 1-2 hours.
Metabolism
Extensively metabolized in the liver primarily by CYP3A4 and other cytochrome P450 enzymes into inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to the active substance or excipients
- Severe hepatic impairment
- Acute narrow-angle glaucoma
- Myasthenia gravis
- Severe respiratory insufficiency
Drug Interactions
Alcohol
Increases CNS depressant effects.
Opioids
Increased risk of respiratory depression and sedation.
Rifampicin
May decrease plasma concentration of Quiet by inducing its metabolism.
Antifungals (e.g., Ketoconazole)
May increase plasma concentration of Quiet by inhibiting its metabolism.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include somnolence, confusion, impaired coordination, diminished reflexes, and coma. Treatment is supportive, including gastric lavage if recent ingestion, and monitoring vital signs. Flumazenil may be used as an antidote in severe cases, but with caution.
Pregnancy & Lactation
Not recommended during pregnancy, especially in the first trimester, due to potential risk of fetal harm. Avoid during lactation as it may pass into breast milk.
Side Effects
Contraindications
- Hypersensitivity to the active substance or excipients
- Severe hepatic impairment
- Acute narrow-angle glaucoma
- Myasthenia gravis
- Severe respiratory insufficiency
Drug Interactions
Alcohol
Increases CNS depressant effects.
Opioids
Increased risk of respiratory depression and sedation.
Rifampicin
May decrease plasma concentration of Quiet by inducing its metabolism.
Antifungals (e.g., Ketoconazole)
May increase plasma concentration of Quiet by inhibiting its metabolism.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include somnolence, confusion, impaired coordination, diminished reflexes, and coma. Treatment is supportive, including gastric lavage if recent ingestion, and monitoring vital signs. Flumazenil may be used as an antidote in severe cases, but with caution.
Pregnancy & Lactation
Not recommended during pregnancy, especially in the first trimester, due to potential risk of fetal harm. Avoid during lactation as it may pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Patent protected
Clinical Trials
Phase III trials demonstrated significant efficacy in reducing sleep latency and improving sleep maintenance compared to placebo in patients with chronic insomnia. Ongoing post-marketing surveillance.
Lab Monitoring
- Liver function tests (baseline and periodically for long-term use)
- Renal function tests (for patients with severe renal impairment)
Doctor Notes
- Prescribe for shortest duration possible.
- Assess patient for risk of substance abuse before initiating therapy.
- Monitor for signs of dependence and withdrawal during treatment and upon discontinuation.
Patient Guidelines
- Do not consume alcohol while taking this medicine.
- Avoid operating heavy machinery or driving until you know how this medicine affects you.
- Take exactly as prescribed by your doctor.
- Do not stop taking abruptly without consulting your doctor to avoid withdrawal symptoms.
Missed Dose Advice
If a dose is missed for insomnia, do not take it unless you can still get a full 7-8 hours of sleep. For anxiety, take the missed dose as soon as you remember, unless it's almost time for the next dose. Do not double the dose.
Driving Precautions
May cause drowsiness, dizziness, and impaired judgment. Patients should be advised not to drive or operate hazardous machinery until they are certain the medication does not adversely affect their ability to perform such activities.
Lifestyle Advice
- Practice good sleep hygiene (consistent sleep schedule, dark/quiet room).
- Limit caffeine and nicotine intake, especially in the evening.
- Engage in regular physical activity, but avoid vigorous exercise close to bedtime.
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