Quiet
Generic Name
Quetiapine Fumarate
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| quiet 25 mg tablet | ৳ 3.00 | ৳ 30.00 |
Description
Overview of the medicine
Quiet 25 mg Tablet contains Quetiapine Fumarate, an atypical antipsychotic used to treat schizophrenia, bipolar disorder, and as an adjunctive treatment for major depressive disorder. It helps restore the balance of certain natural substances (neurotransmitters) in the brain.
Uses & Indications
Dosage
Adults
Initial dose 25 mg twice daily, titrated upwards as tolerated to a target range of 300-800 mg/day depending on indication.
Elderly
Initial dose 25 mg once daily, then increased in increments of 25-50 mg/day to an effective dose.
Renal_impairment
No dose adjustment is generally required, but caution is advised. Initiate at 25 mg/day and titrate slowly.
How to Take
Quiet tablets should be taken orally, with or without food. For immediate-release tablets, it is usually taken twice daily. For extended-release tablets, it is taken once daily, preferably in the evening.
Mechanism of Action
Quetiapine is an atypical antipsychotic with a broad receptor binding profile. It acts as an antagonist at dopamine D1 and D2 receptors, serotonin 5-HT1A and 5-HT2A receptors, histamine H1 receptors, and adrenergic α1 and α2 receptors. Its antipsychotic action is primarily attributed to a combination of dopamine D2 and serotonin 5-HT2A receptor antagonism. It has a higher affinity for 5-HT2A receptors than for D2 receptors.
Pharmacokinetics
Onset
Clinical effects may be seen within a few days for acute psychosis; sedative effects can be within hours.
Excretion
Approximately 73% excreted in urine and 20% in feces, predominantly as metabolites. Less than 1% excreted as unchanged drug.
Half life
Approximately 6-7 hours for Quetiapine and 11-12 hours for the active metabolite norquetiapine.
Absorption
Rapidly and well absorbed after oral administration, peak plasma concentration usually attained within 1.5 hours. Bioavailability is not significantly affected by food.
Metabolism
Extensively metabolized in the liver, primarily by CYP3A4 to form norquetiapine and other inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to quetiapine or any component of the formulation
- Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, erythromycin)
Drug Interactions
Antihypertensives
Potentiates orthostatic hypotension due to alpha-1 adrenergic blockade.
CNS Depressants (e.g., alcohol, benzodiazepines)
Increased risk of sedation and central nervous system depression.
CYP3A4 Inhibitors (e.g., ketoconazole, erythromycin)
May significantly increase quetiapine plasma levels, requiring dose reduction.
CYP3A4 Inducers (e.g., rifampin, carbamazepine, phenytoin)
May significantly decrease quetiapine plasma levels, requiring dose increase.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include drowsiness, sedation, tachycardia, hypotension, and rarely coma or death. Management involves supportive care, ensuring airway patency, and monitoring vital signs. Gastric lavage and activated charcoal may be considered if recent ingestion.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to quetiapine or any component of the formulation
- Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, erythromycin)
Drug Interactions
Antihypertensives
Potentiates orthostatic hypotension due to alpha-1 adrenergic blockade.
CNS Depressants (e.g., alcohol, benzodiazepines)
Increased risk of sedation and central nervous system depression.
CYP3A4 Inhibitors (e.g., ketoconazole, erythromycin)
May significantly increase quetiapine plasma levels, requiring dose reduction.
CYP3A4 Inducers (e.g., rifampin, carbamazepine, phenytoin)
May significantly decrease quetiapine plasma levels, requiring dose increase.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include drowsiness, sedation, tachycardia, hypotension, and rarely coma or death. Management involves supportive care, ensuring airway patency, and monitoring vital signs. Gastric lavage and activated charcoal may be considered if recent ingestion.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved by FDA and DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have demonstrated efficacy and safety in schizophrenia, bipolar disorder, and major depressive disorder. Post-marketing surveillance continues to monitor long-term effects and rare adverse events.
Lab Monitoring
- Baseline and periodic monitoring of blood glucose (risk of hyperglycemia)
- Lipid profile (risk of dyslipidemia)
- Weight and BMI
- Blood pressure
- ECG (especially if cardiac risk factors)
- CBC (rare risk of neutropenia/agranulocytosis)
Doctor Notes
- Educate patients on metabolic risks and importance of lifestyle modifications.
- Monitor for signs of Neuroleptic Malignant Syndrome (NMS) and Tardive Dyskinesia.
- Caution with patients at risk for cardiovascular disease or those with a history of seizures.
- Gradual tapering is necessary upon discontinuation.
Patient Guidelines
- Take as directed by your doctor; do not stop abruptly.
- Avoid alcohol while on this medication.
- Be aware of potential drowsiness and dizziness, especially when starting treatment.
- Report any unusual muscle movements, fever, or changes in mood.
- Regularly monitor weight and blood sugar levels if advised.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause drowsiness, dizziness, and blurred vision. Avoid driving or operating machinery until you know how the medication affects you.
Lifestyle Advice
- Maintain a healthy diet to manage potential weight gain.
- Engage in regular physical activity.
- Avoid sudden changes in posture to prevent dizziness.
- Stay hydrated.
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Global Brand Names
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