Veklury
Generic Name
Ramdivir
Manufacturer
Gilead Sciences (Original), Beximco Pharma (Bangladesh)
Country
USA (Original), Bangladesh (Generic)
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ramdivir 5 mg injection | ৳ 2,000.00 | N/A |
Description
Overview of the medicine
Ramdivir is an antiviral medication used for the treatment of coronavirus disease 2019 (COVID-19) in hospitalized patients. It helps to reduce the viral load and shorten recovery time.
Uses & Indications
Dosage
Adults
200 mg loading dose on Day 1, followed by 100 mg once daily for 4 subsequent days (total 5 days) via intravenous infusion. For severe cases, treatment may extend to 10 days.
Elderly
No specific dose adjustment is required, but caution is advised due to potential for decreased renal/hepatic function.
Renal_impairment
Not recommended for patients with eGFR <30 mL/min due to potential accumulation of excipient sulfobutylether beta-cyclodextrin sodium (SBECD).
How to Take
Administer via intravenous (IV) infusion over 30 to 120 minutes. It must be diluted before administration. Do not administer as a rapid IV injection.
Mechanism of Action
Ramdivir is a prodrug that is metabolized intracellularly to its active nucleoside triphosphate analog. This analog then interferes with viral RNA-dependent RNA polymerase, thereby inhibiting viral replication.
Pharmacokinetics
Onset
Rapid, peak plasma concentration of active metabolite reached in approximately 1.5 hours.
Excretion
Primarily renal excretion (approximately 70% as metabolites, 10% unchanged drug in urine).
Half life
Parent drug: ~1 hour; Active metabolite (GS-441524): ~20-25 hours (intracellular).
Absorption
Administered intravenously, hence 100% bioavailability.
Metabolism
Rapidly metabolized via ester hydrolysis to form the parent nucleoside metabolite GS-441524, which is then phosphorylated to the active triphosphate.
Side Effects
Contraindications
- History of hypersensitivity reaction to Ramdivir or any components of the formulation.
Drug Interactions
Certain antivirals
Potential for additive toxicity or reduced efficacy; consult official guidelines for specific interactions.
Chloroquine/Hydroxychloroquine
Coadministration with Ramdivir is not recommended as it may reduce antiviral activity.
Storage
Store below 30°C (86°F), protect from light. Reconstituted solution should be used immediately or stored for a limited time.
Overdose
No specific antidote available. In case of overdose, manage with supportive care and monitor vital signs and organ function.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Caution advised during breastfeeding; evaluate risk-benefit.
Side Effects
Contraindications
- History of hypersensitivity reaction to Ramdivir or any components of the formulation.
Drug Interactions
Certain antivirals
Potential for additive toxicity or reduced efficacy; consult official guidelines for specific interactions.
Chloroquine/Hydroxychloroquine
Coadministration with Ramdivir is not recommended as it may reduce antiviral activity.
Storage
Store below 30°C (86°F), protect from light. Reconstituted solution should be used immediately or stored for a limited time.
Overdose
No specific antidote available. In case of overdose, manage with supportive care and monitor vital signs and organ function.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Caution advised during breastfeeding; evaluate risk-benefit.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date when stored as per instructions.
Availability
Available in hospitals and pharmacies upon prescription
Approval Status
FDA approved (Emergency Use Authorization/Full Approval for COVID-19), DGDA approved
Patent Status
Patented by Gilead Sciences, generic versions available under voluntary licensing/emergency use
WHO Essential Medicine
YesClinical Trials
Multiple pivotal trials (e.g., ACTT-1, SOLIDARITY trial, GS-US-540-5776) demonstrated efficacy in reducing recovery time and disease progression in hospitalized COVID-19 patients.
Lab Monitoring
- Liver function tests (ALT, AST, bilirubin) before and during treatment
- Renal function (eGFR) before and during treatment
Doctor Notes
- Administer Ramdivir only in settings where patients can be closely monitored for potential adverse reactions.
- Ensure appropriate patient selection based on disease severity and risk factors.
- Monitor liver and renal function throughout the treatment course.
Patient Guidelines
- This medication is administered by a healthcare professional in a hospital setting.
- Report any discomfort or side effects immediately to your doctor or nurse.
- It is crucial to complete the full course of treatment as prescribed.
Missed Dose Advice
If a dose is missed, administer as soon as possible. Do not double the dose to compensate for a missed dose. Resume regular dosing schedule.
Driving Precautions
As Ramdivir is administered in a hospital setting, patients typically do not drive. However, potential side effects like dizziness could impair ability.
Lifestyle Advice
- Maintain good hygiene to prevent further spread of infection.
- Follow doctor's advice on rest and hydration.
- Avoid self-medication.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.