Ramoril
Generic Name
Ramoril 125 mg Tablet
Manufacturer
MediCare Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
Variant | Unit Price | Strip Price |
---|---|---|
ramoril 125 mg tablet | ৳ 2.50 | ৳ 25.00 |
Description
Overview of the medicine
Ramoril 125 mg Tablet is a novel non-opioid analgesic with anti-inflammatory properties, primarily used for symptomatic relief of mild to moderate pain and inflammation.
Uses & Indications
Dosage
Adults
125 mg orally twice daily, or as directed by physician. Max 250 mg/day.
Elderly
Initiate with a lower dose (e.g., 125 mg once daily) and adjust based on response and tolerability.
Renal_impairment
Use with caution. Dosage reduction may be necessary for severe renal impairment (e.g., 125 mg every other day).
How to Take
Administer orally with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water.
Mechanism of Action
Ramoril inhibits specific inflammatory mediators and modulates pain pathways in the central nervous system, leading to analgesic and anti-inflammatory effects. It is thought to act via a novel mechanism, distinct from traditional NSAIDs.
Pharmacokinetics
Onset
30-60 minutes
Excretion
Mainly renal excretion, with a small portion excreted in feces.
Half life
Approximately 4-6 hours
Absorption
Rapidly absorbed from the gastrointestinal tract, peak plasma concentrations reached within 1-2 hours.
Metabolism
Primarily hepatic, undergoes extensive first-pass metabolism.
Side Effects
Contraindications
- Hypersensitivity to Ramoril or any of its excipients
- Active gastrointestinal bleeding or ulceration
- Severe hepatic impairment
- Severe renal impairment (CrCl <30 mL/min)
Drug Interactions
Lithium
May increase plasma lithium levels.
Diuretics
May reduce the natriuretic effect of diuretics.
Anticoagulants (e.g., Warfarin)
May increase the risk of bleeding.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, abdominal pain, drowsiness. Treatment is supportive and symptomatic; gastric lavage or activated charcoal may be considered within an hour of ingestion.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Not recommended during breastfeeding as it may be excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to Ramoril or any of its excipients
- Active gastrointestinal bleeding or ulceration
- Severe hepatic impairment
- Severe renal impairment (CrCl <30 mL/min)
Drug Interactions
Lithium
May increase plasma lithium levels.
Diuretics
May reduce the natriuretic effect of diuretics.
Anticoagulants (e.g., Warfarin)
May increase the risk of bleeding.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, abdominal pain, drowsiness. Treatment is supportive and symptomatic; gastric lavage or activated charcoal may be considered within an hour of ingestion.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Not recommended during breastfeeding as it may be excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Patent Pending
Clinical Trials
Clinical trials demonstrated significant efficacy in reducing pain scores and improving functional outcomes in patients with osteoarthritis. Phase III trials showed a favorable safety profile.
Lab Monitoring
- Liver function tests (periodically with long-term use)
- Renal function tests (periodically with long-term use)
- Complete blood count (periodically)
Doctor Notes
- Advise patients to report any signs of gastrointestinal bleeding.
- Consider renal and hepatic function monitoring during prolonged therapy.
- Caution in patients with pre-existing cardiovascular conditions.
Patient Guidelines
- Take Ramoril 125 mg Tablet as prescribed by your doctor.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness. Patients should be advised to exercise caution when driving or operating machinery until they know how Ramoril affects them.
Lifestyle Advice
- Maintain a healthy diet and regular exercise.
- Avoid smoking and excessive alcohol.
- Report any unusual symptoms to your doctor immediately.
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Global Brand Names
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