Ramoril
Generic Name
Ramoril
Manufacturer
Global Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ramoril 25 mg tablet | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Ramoril 25 mg Tablet is an antidepressant medicine used to treat various mental health conditions, including major depressive disorder, panic disorder, obsessive-compulsive disorder, and generalized anxiety disorder. It works by helping to restore the balance of a certain natural substance (serotonin) in the brain.
Uses & Indications
Dosage
Adults
Initial dose is usually 25 mg once daily, preferably in the morning or evening. May be increased to 50 mg after 1 week. Maximum dose is typically 100 mg daily.
Elderly
A lower initial dose of 12.5 mg once daily may be considered, with gradual titration based on response and tolerability. Maximum 50 mg daily.
Renal_impairment
No specific dosage adjustment is generally required for mild to moderate renal impairment. Use with caution in severe renal impairment.
How to Take
Take Ramoril 25 mg Tablet orally, once daily, with or without food. It is recommended to take it at the same time each day to maintain consistent drug levels.
Mechanism of Action
Ramoril selectively inhibits the reuptake of serotonin (5-HT) by the presynaptic neuron, thereby increasing the concentration of serotonin in the synaptic cleft. This leads to enhanced serotonergic neurotransmission in the central nervous system.
Pharmacokinetics
Onset
Initial therapeutic effects may be observed within 1-2 weeks, but full antidepressant effects typically take 2-4 weeks of consistent dosing.
Excretion
Approximately 60% of metabolites are excreted via the kidneys (urine) and about 40% via feces.
Half life
The elimination half-life is approximately 24-30 hours, allowing for once-daily dosing.
Absorption
Well absorbed after oral administration, with peak plasma concentrations (Tmax) generally reached within 4-8 hours. Bioavailability is approximately 80%.
Metabolism
Extensively metabolized in the liver, primarily via CYP450 isoenzymes (e.g., CYP2D6, CYP2C19), into inactive or less active metabolites.
Side Effects
Contraindications
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing an MAOI.
- Known hypersensitivity to Ramoril or any of its excipients.
- Severe hepatic impairment.
Drug Interactions
Alcohol
Avoid concurrent use due to enhanced CNS depressant effects.
Diuretics
Increased risk of hyponatremia.
Triptans (e.g., sumatriptan)
Increased risk of serotonin syndrome.
Warfarin and other anticoagulants
Increased risk of bleeding due to Ramoril's potential effect on platelet aggregation.
Monoamine Oxidase Inhibitors (MAOIs)
Concurrent use may lead to serotonin syndrome, a potentially life-threatening condition.
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Increased risk of gastrointestinal bleeding when co-administered.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, drowsiness, tremor, tachycardia, agitation, and dizziness. In severe cases, seizures and serotonin syndrome may occur. Management involves supportive and symptomatic treatment. Ensure adequate airway, monitor cardiac function, and vital signs.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Ramoril is excreted in breast milk; therefore, caution should be exercised when administered to a nursing mother. Consult your doctor.
Side Effects
Contraindications
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing an MAOI.
- Known hypersensitivity to Ramoril or any of its excipients.
- Severe hepatic impairment.
Drug Interactions
Alcohol
Avoid concurrent use due to enhanced CNS depressant effects.
Diuretics
Increased risk of hyponatremia.
Triptans (e.g., sumatriptan)
Increased risk of serotonin syndrome.
Warfarin and other anticoagulants
Increased risk of bleeding due to Ramoril's potential effect on platelet aggregation.
Monoamine Oxidase Inhibitors (MAOIs)
Concurrent use may lead to serotonin syndrome, a potentially life-threatening condition.
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Increased risk of gastrointestinal bleeding when co-administered.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, drowsiness, tremor, tachycardia, agitation, and dizziness. In severe cases, seizures and serotonin syndrome may occur. Management involves supportive and symptomatic treatment. Ensure adequate airway, monitor cardiac function, and vital signs.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Ramoril is excreted in breast milk; therefore, caution should be exercised when administered to a nursing mother. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by Directorate General of Drug Administration (DGDA)
Patent Status
Patent expired, generic versions available
Clinical Trials
Extensive clinical trials (Phase I, II, and III) have demonstrated the efficacy and safety of Ramoril in the treatment of major depressive disorder and various anxiety disorders. Post-marketing surveillance continues to monitor long-term outcomes.
Lab Monitoring
- Liver function tests (LFTs) periodically, especially in patients with pre-existing hepatic impairment.
- Serum electrolytes (e.g., sodium) if hyponatremia is suspected.
- Renal function tests if there is severe renal impairment.
Doctor Notes
- Educate patients on the delayed onset of action (2-4 weeks) and the importance of adherence to treatment for optimal outcomes.
- Monitor for suicidal ideation, especially at the initiation of therapy or during dose adjustments, particularly in younger patients.
- Counsel patients on potential sexual side effects and strategies for management if troublesome.
Patient Guidelines
- Do not stop taking Ramoril abruptly; it can lead to withdrawal symptoms. Always consult your doctor before making any changes.
- Take the medicine exactly as prescribed by your doctor.
- Report any unusual mood changes, worsening depression, or thoughts of self-harm to your doctor immediately.
- Avoid consuming alcohol while on this medication.
Missed Dose Advice
If you miss a dose of Ramoril, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Ramoril may cause drowsiness, dizziness, or blurred vision. Do not drive or operate heavy machinery until you know how this medicine affects you. If you experience these side effects, avoid activities requiring mental alertness.
Lifestyle Advice
- Engage in regular physical activity as advised by your doctor.
- Maintain a balanced diet and stay hydrated.
- Practice stress management techniques such as meditation or yoga.
- Ensure adequate sleep (7-9 hours per night).
- Consider psychotherapy or counseling in conjunction with medication.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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