Ranzo
Generic Name
Rabeprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ranzo 20 mg capsule | ৳ 4.00 | N/A |
Description
Overview of the medicine
Ranzo (Rabeprazole) is a proton pump inhibitor that decreases the amount of acid produced in the stomach. It is used to treat conditions like heartburn, acid reflux, ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
Gastroesophageal Reflux Disease (GERD): 20 mg once daily for 4 to 8 weeks. Duodenal Ulcers: 20 mg once daily for 4 weeks. H. pylori eradication: 20 mg twice daily in combination with antibiotics.
Elderly
No specific dose adjustment is required.
Renal_impairment
No dosage adjustment is necessary for patients with renal impairment.
How to Take
Take orally, usually once daily in the morning before a meal. Swallow the tablet whole; do not crush, chew, or split it.
Mechanism of Action
Rabeprazole irreversibly blocks the hydrogen-potassium adenosine triphosphatase (H+/K+-ATPase) enzyme system, also known as the proton pump, in the gastric parietal cells. This reduces gastric acid secretion.
Pharmacokinetics
Onset
Onset of antisecretory effect within 1 hour.
Excretion
Approximately 90% is excreted in the urine and the remainder in the feces.
Half life
Plasma elimination half-life is approximately 1 to 2 hours.
Absorption
Rapidly absorbed after oral administration. Oral bioavailability is about 52%.
Metabolism
Metabolized primarily in the liver by the cytochrome P450 system (CYP2C19 and CYP3A4).
Side Effects
Contraindications
- Known hypersensitivity to rabeprazole, substituted benzimidazoles, or any component of the formulation.
- Patients with severe liver impairment.
Drug Interactions
Digoxin
Increased digoxin levels.
Warfarin
Increased INR and prothrombin time.
Methotrexate
Increased methotrexate levels, especially with high dose methotrexate.
Atazanavir/Nelfinavir
Reduced plasma levels, potentially reducing efficacy. Co-administration generally not recommended.
Ketoconazole/Itraconazole
Decreased absorption due to increased gastric pH.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
There is no known specific antidote. In case of overdose, treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown a risk, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. It is not known whether rabeprazole is excreted in human milk, therefore caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Known hypersensitivity to rabeprazole, substituted benzimidazoles, or any component of the formulation.
- Patients with severe liver impairment.
Drug Interactions
Digoxin
Increased digoxin levels.
Warfarin
Increased INR and prothrombin time.
Methotrexate
Increased methotrexate levels, especially with high dose methotrexate.
Atazanavir/Nelfinavir
Reduced plasma levels, potentially reducing efficacy. Co-administration generally not recommended.
Ketoconazole/Itraconazole
Decreased absorption due to increased gastric pH.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
There is no known specific antidote. In case of overdose, treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown a risk, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. It is not known whether rabeprazole is excreted in human milk, therefore caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Off-patent
Clinical Trials
Extensively studied in various clinical trials for its efficacy and safety in conditions like GERD, peptic ulcers, and H. pylori eradication. Ongoing research explores long-term effects and new indications.
Lab Monitoring
- Magnesium levels should be monitored in patients expected to be on long-term treatment.
- Liver function tests in patients with severe hepatic impairment.
Doctor Notes
- Before prescribing, review patient's full medical history, including liver function and concurrent medications.
- Educate patients on potential long-term risks, especially for those requiring prolonged therapy.
- Consider screening for H. pylori before initiating long-term PPI therapy for dyspepsia.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not stop taking the medicine abruptly without consulting your doctor.
- Inform your doctor about any new or worsening symptoms.
- Avoid crushing or chewing the tablet.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Ranzo may cause dizziness or visual disturbances in some patients. If these symptoms occur, avoid driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods and beverages (e.g., spicy food, fatty food, caffeine, alcohol).
- Eat smaller, more frequent meals.
- Elevate the head of your bed if you experience nighttime reflux.
- Quit smoking if applicable.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Ranzo Brand
Other medicines available under the same brand name
