Rasonix
Generic Name
Esomeprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rasonix 20 mg capsule | ৳ 8.00 | ৳ 64.00 |
Description
Overview of the medicine
Rasonix 20 mg Capsule contains Esomeprazole, a proton pump inhibitor, used to reduce stomach acid production. It treats conditions like acid reflux (GERD), heartburn, ulcers, and prevents NSAID-induced gastric damage.
Uses & Indications
Dosage
Adults
For GERD: 20 mg or 40 mg once daily for 4-8 weeks. For Erosive Esophagitis: 20 mg or 40 mg once daily for 4-8 weeks. For H. pylori eradication: 20 mg twice daily (in combination with antibiotics).
Elderly
No specific dosage adjustment is generally required, but caution is advised in very elderly patients due to potential comorbidities.
Renal_impairment
No dosage adjustment is necessary for patients with impaired renal function. However, caution is advised in patients with severe renal impairment.
How to Take
Take Rasonix capsule whole at least one hour before a meal. Do not chew or crush the capsule. If swallowing is difficult, the capsule can be opened and the pellets mixed with a small amount of water or soft food (e.g., apple sauce), then swallowed immediately.
Mechanism of Action
Esomeprazole selectively inhibits the H+/K+-ATPase enzyme system (the proton pump) at the secretory surface of the gastric parietal cell. This leads to a profound and sustained reduction in gastric acid secretion.
Pharmacokinetics
Onset
Acid inhibitory effect starts within one hour of oral administration.
Excretion
Approximately 80% of metabolites are excreted in the urine, and 20% in the feces.
Half life
Plasma elimination half-life is approximately 1-1.5 hours.
Absorption
Rapidly absorbed after oral administration. Bioavailability is approximately 64% with a 20 mg dose, increasing to 89% with repeated once-daily administration.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 system (primarily CYP2C19 and CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir (an antiretroviral).
Drug Interactions
Warfarin
Increased INR (International Normalized Ratio) and prothrombin time, monitor for bleeding.
Clopidogrel
Esomeprazole may reduce the antiplatelet effect of clopidogrel.
Methotrexate
May increase serum levels of methotrexate, particularly with high doses.
Nelfinavir/Atazanavir
Reduced plasma concentrations of antiretrovirals, avoid concomitant use.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of the reach and sight of children.
Overdose
There is limited experience with Esomeprazole overdose. Symptoms are generally mild and reversible. Management is symptomatic and supportive; no specific antidote is known.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Avoid during breastfeeding, or discontinue the drug, considering the importance of the drug to the mother.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir (an antiretroviral).
Drug Interactions
Warfarin
Increased INR (International Normalized Ratio) and prothrombin time, monitor for bleeding.
Clopidogrel
Esomeprazole may reduce the antiplatelet effect of clopidogrel.
Methotrexate
May increase serum levels of methotrexate, particularly with high doses.
Nelfinavir/Atazanavir
Reduced plasma concentrations of antiretrovirals, avoid concomitant use.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of the reach and sight of children.
Overdose
There is limited experience with Esomeprazole overdose. Symptoms are generally mild and reversible. Management is symptomatic and supportive; no specific antidote is known.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Avoid during breastfeeding, or discontinue the drug, considering the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture, specific details are printed on the packaging.
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Esomeprazole in various acid-related disorders, supporting its use in GERD, erosive esophagitis, and H. pylori eradication.
Lab Monitoring
- Monitor magnesium levels, especially during long-term therapy (over 3 months) or with other magnesium-depleting drugs.
- Monitor Vitamin B12 levels in patients on long-term therapy.
Doctor Notes
- Educate patients on proper administration and potential long-term risks.
- Consider lowest effective dose for shortest duration possible, especially in elderly.
- Monitor for signs of hypomagnesemia and B12 deficiency in prolonged use.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking Rasonix abruptly without consulting your doctor, as symptoms may return.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Esomeprazole is generally not expected to affect the ability to drive or use machinery. However, some adverse reactions like dizziness or blurred vision may occur, which could impair these abilities. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid foods and drinks that trigger your symptoms (e.g., spicy, fatty, acidic foods, caffeine, alcohol).
- Eat smaller, more frequent meals and avoid lying down immediately after eating.
- Elevate the head of your bed for GERD symptoms.
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