Rebreath
Generic Name
Montelukast
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rebreath 175 mg solution for inhalation | ৳ 80.00 | N/A |
Description
Overview of the medicine
Rebreath (Montelukast) is a leukotriene receptor antagonist used for the prophylaxis and chronic treatment of asthma and for the relief of symptoms of seasonal and perennial allergic rhinitis.
Uses & Indications
Dosage
Adults
10 mg once daily in the evening.
Elderly
No dosage adjustment is generally required.
Renal_impairment
No dosage adjustment is required for patients with renal impairment.
How to Take
Take orally, once daily in the evening, with or without food.
Mechanism of Action
Montelukast selectively binds to and inhibits the cysteinyl leukotriene 1 (CysLT1) receptor, thereby blocking the action of leukotrienes, which are potent inflammatory mediators involved in asthma and allergic rhinitis.
Pharmacokinetics
Onset
Clinical effects generally observed within 1 day.
Excretion
Primarily excreted in feces via bile (approximately 86% of the orally administered dose), less than 0.2% in urine.
Half life
Approximately 2.7 to 5.5 hours.
Absorption
Rapidly absorbed after oral administration, peak plasma concentration reached in 2-4 hours.
Metabolism
Extensively metabolized in the liver, primarily by CYP3A4, CYP2C9, and CYP2C8.
Side Effects
Contraindications
- Hypersensitivity to Montelukast or any component of the formulation.
Drug Interactions
Rifampin
May decrease Montelukast levels, clinical significance unknown.
Phenobarbital
May decrease Montelukast levels.
Storage
Store in a cool and dry place, away from light. Do not store above 30°C.
Overdose
No specific antidote. Symptomatic and supportive treatment should be initiated in case of overdose.
Pregnancy & Lactation
Pregnancy Category B. Should be used during pregnancy only if clearly needed. Exercise caution when administering to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to Montelukast or any component of the formulation.
Drug Interactions
Rifampin
May decrease Montelukast levels, clinical significance unknown.
Phenobarbital
May decrease Montelukast levels.
Storage
Store in a cool and dry place, away from light. Do not store above 30°C.
Overdose
No specific antidote. Symptomatic and supportive treatment should be initiated in case of overdose.
Pregnancy & Lactation
Pregnancy Category B. Should be used during pregnancy only if clearly needed. Exercise caution when administering to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Clinical trials have demonstrated Montelukast's efficacy in improving asthma control, reducing exacerbations, and alleviating allergic rhinitis symptoms in various age groups.
Lab Monitoring
- No routine laboratory monitoring is generally required for Montelukast.
Doctor Notes
- Educate patients that Rebreath is a controller medication and not for acute relief.
- Monitor patients for neuropsychiatric symptoms, especially during initiation and dose changes.
- Consider potential drug interactions, especially with enzyme inducers.
Patient Guidelines
- Take Rebreath regularly, even when feeling well.
- Do not use Rebreath for acute asthma attacks; use a fast-acting inhaled bronchodilator for quick relief.
- Do not stop taking Rebreath abruptly without consulting your doctor.
- Inform your doctor about any new or worsening neuropsychiatric symptoms.
Missed Dose Advice
If a dose is missed, take the next dose at the regular time. Do not take a double dose to make up for a missed one.
Driving Precautions
Rebreath is generally not expected to affect the ability to drive or operate machinery, but patients should be aware of possible side effects like dizziness or somnolence.
Lifestyle Advice
- Identify and avoid asthma and allergy triggers (e.g., dust mites, pollen, pet dander).
- Maintain a healthy lifestyle, including regular exercise and a balanced diet.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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