Recogen
Generic Name
Cholecalciferol (Vitamin D3)
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| recogen 2000 iu injection | ৳ 1,136.00 | N/A |
Description
Overview of the medicine
Recogen 2000 IU Injection is a vitamin D3 supplement (cholecalciferol) used to treat and prevent vitamin D deficiency. It helps the body absorb calcium and phosphorus, crucial for maintaining strong bones and overall health.
Uses & Indications
Dosage
Adults
2000 IU once daily or as directed by physician for maintenance. Higher doses (e.g., 200,000 IU or 600,000 IU) are given monthly/quarterly for severe deficiency.
Elderly
Same as adult dose, close monitoring may be required.
Renal_impairment
Use with caution; dose adjustment may be necessary. Monitoring of calcium and phosphate levels is crucial.
How to Take
Intramuscular injection, usually in the gluteal or deltoid muscle. Administer slowly.
Mechanism of Action
Cholecalciferol is metabolized in the liver to 25-hydroxycholecalciferol (calcidiol) and then in the kidneys to 1,25-dihydroxycholecalciferol (calcitriol), the active form of vitamin D. Calcitriol binds to vitamin D receptors in various tissues, regulating calcium and phosphate homeostasis, promoting bone mineralization, and influencing immune function.
Pharmacokinetics
Onset
Within hours, sustained effect over weeks/months depending on dose.
Excretion
Excreted primarily in bile and feces, a small amount in urine.
Half life
Terminal half-life of 25-hydroxyvitamin D3 is approximately 15 days.
Absorption
Rapidly absorbed from the site of intramuscular injection. Peak serum levels are usually reached within 7-10 days for oral, but for injection, it is faster and sustained.
Metabolism
Primarily hepatic hydroxylation to 25-hydroxyvitamin D3 (calcidiol), then renal hydroxylation to 1,25-dihydroxyvitamin D3 (calcitriol).
Side Effects
Contraindications
- Hypercalcemia
- Hypervitaminosis D
- Malabsorption syndrome (unless deficiency is due to this)
Drug Interactions
Cardiac glycosides
Increased toxicity risk with hypercalcemia.
Thiazide diuretics
May increase risk of hypercalcemia.
Phenytoin/Barbiturates
May increase vitamin D metabolism, reducing efficacy.
Storage
Store in a cool, dry place below 30°C. Protect from light. Do not freeze.
Overdose
Symptoms include hypercalcemia (nausea, vomiting, weakness, polyuria, thirst), hyperphosphatemia, and potentially renal damage. Treatment involves discontinuation of vitamin D, low calcium diet, hydration, and in severe cases, corticosteroids or calcitonin.
Pregnancy & Lactation
Essential during pregnancy and lactation. However, doses should be carefully monitored to avoid hypervitaminosis D. Consult a doctor.
Side Effects
Contraindications
- Hypercalcemia
- Hypervitaminosis D
- Malabsorption syndrome (unless deficiency is due to this)
Drug Interactions
Cardiac glycosides
Increased toxicity risk with hypercalcemia.
Thiazide diuretics
May increase risk of hypercalcemia.
Phenytoin/Barbiturates
May increase vitamin D metabolism, reducing efficacy.
Storage
Store in a cool, dry place below 30°C. Protect from light. Do not freeze.
Overdose
Symptoms include hypercalcemia (nausea, vomiting, weakness, polyuria, thirst), hyperphosphatemia, and potentially renal damage. Treatment involves discontinuation of vitamin D, low calcium diet, hydration, and in severe cases, corticosteroids or calcitonin.
Pregnancy & Lactation
Essential during pregnancy and lactation. However, doses should be carefully monitored to avoid hypervitaminosis D. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years when stored correctly.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by regulatory bodies
Patent Status
Expired
WHO Essential Medicine
YesClinical Trials
Extensively studied for its role in bone health and vitamin D deficiency. Ongoing research explores its role in immune function, cardiovascular health, and various chronic diseases.
Lab Monitoring
- Serum 25(OH)D levels
- Serum calcium levels
- Serum phosphate levels
- Renal function tests
Doctor Notes
- Ensure correct injection technique.
- Monitor serum calcium and 25(OH)D levels regularly, especially in patients with pre-existing conditions or on high doses.
- Educate patients on symptoms of hypercalcemia.
Patient Guidelines
- Follow doctor's dosage instructions strictly.
- Report any unusual symptoms immediately.
- Maintain a balanced diet.
- Do not self-medicate or exceed prescribed dose.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Driving Precautions
Generally no specific precautions. However, if experiencing dizziness or weakness, avoid driving.
Lifestyle Advice
- Ensure adequate sunlight exposure (while protecting from harmful UV rays).
- Consume calcium-rich foods.
- Regular exercise.
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