Recogen
Generic Name
Human Chorionic Gonadotropin (HCG)
Manufacturer
Acme Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| recogen 3000 iu injection | ৳ 1,480.00 | N/A |
Description
Overview of the medicine
Human Chorionic Gonadotropin (HCG) is a hormone used in fertility treatments for both men and women, and for certain pediatric conditions.
Uses & Indications
Dosage
Adults
Dosage varies significantly based on indication. For ovulation induction: typically 5,000 to 10,000 IU one single injection. For male hypogonadism: 500 to 4,000 IU, 2-3 times per week.
Elderly
Use with caution; no specific dose adjustments generally required, but monitor for age-related conditions.
Renal_impairment
No specific dose adjustments provided; use with caution due to renal excretion.
How to Take
Administered via intramuscular (IM) or subcutaneous (SC) injection by a healthcare professional, or self-administered after proper training.
Mechanism of Action
HCG mimics the action of Luteinizing Hormone (LH), stimulating gonadal steroidogenesis and follicular maturation in females, and testosterone production in males.
Pharmacokinetics
Onset
Onset of action for ovulation typically within 36-40 hours; effects on spermatogenesis or testosterone production are gradual, over days to weeks.
Excretion
Excreted mainly via the kidneys in urine.
Half life
Approximately 24-36 hours.
Absorption
Rapidly absorbed after intramuscular (IM) or subcutaneous (SC) injection.
Metabolism
Primarily metabolized in the liver and kidneys.
Side Effects
Contraindications
- Hypersensitivity to HCG or any component of the formulation.
- Androgen-dependent tumors (e.g., prostate carcinoma, male breast carcinoma).
- Precocious puberty (in cryptorchidism).
- Uncontrolled thyroid or adrenal dysfunction.
- Abnormal vaginal bleeding of undetermined origin.
Drug Interactions
Other fertility drugs
Concurrent use with other gonadotropins (e.g., FSH) can enhance ovarian response and requires careful monitoring.
Gonadotropin-releasing hormone (GnRH) analogs
May modify the response to HCG, requiring dose adjustments.
Storage
Store in a refrigerator (2-8°C). Do not freeze. Protect from light. Once reconstituted, use immediately or store as directed by the manufacturer (usually within 24 hours).
Overdose
Overdose in women may lead to Ovarian Hyperstimulation Syndrome (OHSS), characterized by severe abdominal pain, bloating, nausea, vomiting, and in severe cases, ascites, pleural effusion, and electrolyte imbalance. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Contraindicated in pregnancy, except for specific diagnostic uses. Not recommended during lactation as HCG is secreted into breast milk and its effects on the infant are unknown.
Side Effects
Contraindications
- Hypersensitivity to HCG or any component of the formulation.
- Androgen-dependent tumors (e.g., prostate carcinoma, male breast carcinoma).
- Precocious puberty (in cryptorchidism).
- Uncontrolled thyroid or adrenal dysfunction.
- Abnormal vaginal bleeding of undetermined origin.
Drug Interactions
Other fertility drugs
Concurrent use with other gonadotropins (e.g., FSH) can enhance ovarian response and requires careful monitoring.
Gonadotropin-releasing hormone (GnRH) analogs
May modify the response to HCG, requiring dose adjustments.
Storage
Store in a refrigerator (2-8°C). Do not freeze. Protect from light. Once reconstituted, use immediately or store as directed by the manufacturer (usually within 24 hours).
Overdose
Overdose in women may lead to Ovarian Hyperstimulation Syndrome (OHSS), characterized by severe abdominal pain, bloating, nausea, vomiting, and in severe cases, ascites, pleural effusion, and electrolyte imbalance. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Contraindicated in pregnancy, except for specific diagnostic uses. Not recommended during lactation as HCG is secreted into breast milk and its effects on the infant are unknown.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Refer to the manufacturer's packaging for specific shelf life. Typically 2-3 years when stored correctly.
Availability
Pharmacies, hospitals, fertility clinics
Approval Status
Approved by regulatory bodies worldwide
Patent Status
Generic (off-patent)
Clinical Trials
Extensive clinical trials and decades of clinical experience have established the efficacy and safety of HCG in its approved indications. Ongoing research continues to refine its use.
Lab Monitoring
- Serum estradiol levels (in women during fertility treatment)
- Ultrasound monitoring of follicular development (in women)
- Serum testosterone levels (in males receiving treatment for hypogonadism)
- Electrolyte balance and renal function (in cases of OHSS)
Doctor Notes
- Careful patient selection, counseling, and monitoring (clinical and biochemical) are essential to minimize risks such as OHSS and multiple gestations.
- Educate patients thoroughly on the proper technique for self-administration (if applicable) and recognition of adverse effects, particularly OHSS symptoms.
- Ensure patients understand that HCG is not for weight loss and its misuse can be harmful.
Patient Guidelines
- Follow your doctor's instructions precisely regarding dosage and administration.
- Report any severe abdominal pain, swelling, or sudden weight gain immediately to your doctor.
- Do not use this medication for purposes other than what it was prescribed for, especially not for weight loss.
- Store the medication as directed and do not use it past its expiration date.
Missed Dose Advice
If a dose is missed, contact your doctor for advice. Do not double the dose.
Driving Precautions
Generally, HCG does not impair the ability to drive or operate machinery. However, if you experience dizziness or visual disturbances, avoid such activities.
Lifestyle Advice
- Maintain a healthy diet and lifestyle as advised by your healthcare provider.
- Avoid strenuous physical activity if symptoms of OHSS appear or are suspected.
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