Reflacid
Generic Name
Esomeprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| reflacid 500 mg suspension | ৳ 150.00 | N/A |
Description
Overview of the medicine
Reflacid contains Esomeprazole, a proton pump inhibitor (PPI) used to treat conditions where there is too much acid in the stomach.
Uses & Indications
Dosage
Adults
For most conditions, 20-40 mg once daily, 30-60 minutes before a meal. Duration varies by indication.
Elderly
No specific dose adjustment is generally required for elderly patients.
Renal_impairment
No dose adjustment is generally required for patients with renal impairment.
How to Take
Take the capsule orally, at least one hour before a meal. Swallow whole with water; do not chew or crush. For patients with difficulty swallowing, the capsule can be opened and the pellets mixed with a small amount of water or applesauce.
Mechanism of Action
Esomeprazole works by irreversibly binding to and inhibiting the H+/K+-ATPase (proton pump) in the gastric parietal cells, thereby reducing gastric acid secretion.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Excreted primarily in urine (80%) and feces (20%).
Half life
Approximately 1-1.5 hours
Absorption
Rapidly absorbed after oral administration. Bioavailability increases with repeated dosing.
Metabolism
Extensively metabolized in the liver by CYP2C19 and CYP3A4 enzymes.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Digoxin
Increased digoxin levels.
Warfarin
Increased INR and prothrombin time.
Clopidogrel
Reduced antiplatelet effect of clopidogrel.
Atazanavir, Nelfinavir
Reduced plasma levels of these antiretrovirals, potentially leading to loss of therapeutic effect and development of resistance.
Ketoconazole, Itraconazole
Reduced absorption due to increased gastric pH.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. Symptoms may include gastrointestinal disturbances and weakness. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Esomeprazole is excreted in human milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Digoxin
Increased digoxin levels.
Warfarin
Increased INR and prothrombin time.
Clopidogrel
Reduced antiplatelet effect of clopidogrel.
Atazanavir, Nelfinavir
Reduced plasma levels of these antiretrovirals, potentially leading to loss of therapeutic effect and development of resistance.
Ketoconazole, Itraconazole
Reduced absorption due to increased gastric pH.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. Symptoms may include gastrointestinal disturbances and weakness. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Esomeprazole is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from the date of manufacture
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Generic versions available
WHO Essential Medicine
YesClinical Trials
Esomeprazole has been extensively studied in numerous clinical trials demonstrating its efficacy and safety for various acid-related disorders.
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration necessary to achieve therapeutic objectives.
- Consider magnesium monitoring for patients on long-term therapy or concomitant diuretics.
- Advise patients on potential long-term risks.
Patient Guidelines
- Take Reflacid exactly as prescribed by your doctor.
- Do not crush, chew, or break the capsule.
- Inform your doctor about all other medications you are taking.
- Seek medical attention if you experience severe abdominal pain, persistent diarrhea, or signs of an allergic reaction.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Reflacid may cause dizziness or visual disturbances in some patients. If these symptoms occur, avoid driving or operating machinery.
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