Reladol
Generic Name
Paracetamol
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| reladol 100 mg injection | ৳ 20.00 | N/A |
Description
Overview of the medicine
Reladol is a brand of Paracetamol, a widely used medication for the relief of pain and reduction of fever. It works by inhibiting prostaglandin synthesis primarily in the central nervous system.
Uses & Indications
Dosage
Adults
For 500 mg tablet: 1-2 tablets (500-1000 mg) every 4-6 hours as needed. Maximum 4000 mg in 24 hours.
Elderly
No specific dose reduction required, but caution is advised in frail elderly patients or those with impaired liver/kidney function.
Renal_impairment
Dose interval may need to be extended in severe renal impairment (e.g., creatinine clearance <10 mL/min, dose every 8 hours).
How to Take
Oral (tablets, syrup, suspension, drops) or Rectal (suppositories). Can be taken with or without food. For rapid absorption, take on an empty stomach.
Mechanism of Action
Paracetamol primarily acts by inhibiting prostaglandin synthesis within the central nervous system, which contributes to its analgesic (pain-relieving) and antipyretic (fever-reducing) effects. Its exact mechanism on COX enzymes is not fully understood, but it is believed to selectively inhibit COX-2 and also has an effect on COX-3.
Pharmacokinetics
Onset
Analgesic effect within 30-60 minutes, antipyretic effect within 30-60 minutes.
Excretion
Mainly excreted in the urine as glucuronide and sulfate conjugates. Less than 5% is excreted unchanged.
Half life
Approximately 1.25 to 3 hours in adults.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 30-60 minutes.
Metabolism
Primarily metabolized in the liver via glucuronidation and sulfation. A small amount is metabolized by cytochrome P450 to a highly reactive intermediate (NAPQI) which is detoxified by glutathione.
Side Effects
Contraindications
- Hypersensitivity to Paracetamol or any component of the formulation
- Severe hepatic impairment or active liver disease
Drug Interactions
Alcohol
Increased risk of hepatotoxicity with chronic alcohol consumption.
Warfarin and other coumarins
May increase the anticoagulant effect, leading to an increased risk of bleeding, especially with prolonged use of high doses of paracetamol.
Carbamazepine, Phenobarbital, Phenytoin, Rifampicin
Increased risk of hepatotoxicity due to induction of hepatic enzymes.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, abdominal pain, sweating, and malaise, potentially leading to liver damage and acute liver failure. Treatment involves gastric lavage, activated charcoal, and administration of N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and breastfeeding at recommended doses. However, always consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to Paracetamol or any component of the formulation
- Severe hepatic impairment or active liver disease
Drug Interactions
Alcohol
Increased risk of hepatotoxicity with chronic alcohol consumption.
Warfarin and other coumarins
May increase the anticoagulant effect, leading to an increased risk of bleeding, especially with prolonged use of high doses of paracetamol.
Carbamazepine, Phenobarbital, Phenytoin, Rifampicin
Increased risk of hepatotoxicity due to induction of hepatic enzymes.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, abdominal pain, sweating, and malaise, potentially leading to liver damage and acute liver failure. Treatment involves gastric lavage, activated charcoal, and administration of N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and breastfeeding at recommended doses. However, always consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years from the date of manufacture, depending on the formulation and packaging.
Availability
Pharmacies, drugstores, supermarkets, general stores
Approval Status
Approved by DGDA and internationally for decades
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensively studied and validated in numerous clinical trials over decades for its efficacy and safety. Newer trials often focus on specific populations or formulations.
Lab Monitoring
- Liver function tests (LFTs) may be monitored in cases of chronic use or suspected overdose.
- Renal function tests may be considered in patients with pre-existing renal impairment.
Doctor Notes
- Emphasize patient education on not exceeding the maximum daily dose to prevent hepatotoxicity.
- Be aware of potential drug interactions with anticoagulants and enzyme inducers.
- Consider baseline liver function in patients with pre-existing hepatic conditions.
Patient Guidelines
- Do not exceed the recommended dose.
- Consult a doctor if pain or fever persists for more than a few days.
- Avoid concurrent use with other paracetamol-containing products.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not double the dose to catch up.
Driving Precautions
Paracetamol is generally not expected to affect the ability to drive or operate machinery. However, if any unusual effects are experienced, caution should be exercised.
Lifestyle Advice
- Ensure adequate hydration when experiencing fever.
- Get sufficient rest to aid recovery.
- Avoid alcohol consumption during treatment, especially with chronic use.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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