Remacid
Generic Name
Ranitidine
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| remacid 175 mg suspension | ৳ 32.50 | N/A |
Description
Overview of the medicine
Remacid contains Ranitidine, an H2-receptor antagonist that inhibits stomach acid production. It is used to treat and prevent various conditions caused by excessive stomach acid.
Uses & Indications
Dosage
Adults
For active duodenal or gastric ulcers: 150 mg twice daily or 300 mg once daily at bedtime. For GERD: 150 mg twice daily.
Elderly
Generally no dosage adjustment required, but renal function should be assessed.
Renal_impairment
For creatinine clearance <50 mL/min, reduce dose to 150 mg once daily.
How to Take
Tablets can be taken orally, with or without food. Injections are administered intravenously or intramuscularly.
Mechanism of Action
Ranitidine selectively blocks histamine H2-receptors on the gastric parietal cells, thereby reducing both basal and stimulated gastric acid secretion.
Pharmacokinetics
Onset
Within 30-60 minutes after oral administration.
Excretion
Mainly through urine (60-70% as unchanged drug) and some in feces.
Half life
Approximately 2-3 hours, prolonged in renal impairment.
Absorption
Rapidly absorbed after oral administration, bioavailability approximately 50%. Peak plasma concentrations are reached within 1-3 hours.
Metabolism
Primarily in the liver, producing N-oxide, S-oxide, and demethylated metabolites.
Side Effects
Contraindications
- Hypersensitivity to ranitidine or any component of the formulation
- Acute porphyria
Drug Interactions
Warfarin
Monitor INR carefully, as ranitidine may prolong prothrombin time.
Atazanavir
Reduced plasma levels of atazanavir; co-administration is generally not recommended.
Ketoconazole, Itraconazole
Reduced absorption due to ranitidine's effect on gastric pH.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. Symptoms may include transient adverse effects. Management involves symptomatic and supportive treatment. Gastric lavage and activated charcoal may be considered if recent ingestion.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in breast milk, so caution advised during lactation.
Side Effects
Contraindications
- Hypersensitivity to ranitidine or any component of the formulation
- Acute porphyria
Drug Interactions
Warfarin
Monitor INR carefully, as ranitidine may prolong prothrombin time.
Atazanavir
Reduced plasma levels of atazanavir; co-administration is generally not recommended.
Ketoconazole, Itraconazole
Reduced absorption due to ranitidine's effect on gastric pH.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. Symptoms may include transient adverse effects. Management involves symptomatic and supportive treatment. Gastric lavage and activated charcoal may be considered if recent ingestion.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in breast milk, so caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA/FDA
Patent Status
Generic available, patent expired
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of ranitidine for its approved indications before the NDMA contamination issues.
Lab Monitoring
- Monitor liver function tests periodically, especially with high doses or prolonged therapy.
- Monitor renal function in patients with kidney impairment.
- Complete blood count (CBC) for prolonged therapy.
Doctor Notes
- Advise patients about the historical NDMA impurity concerns with ranitidine products, and reassure them if currently available products are cleared.
- Consider alternative H2 blockers or PPIs if patients have concerns.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Inform your doctor if you experience any unusual side effects or worsening of symptoms.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or lightheadedness in some individuals. Exercise caution when driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Avoid foods and drinks that trigger indigestion or heartburn, such as spicy foods, fatty foods, caffeine, and alcohol.
- Quit smoking, as it can worsen ulcer symptoms.
- Eat smaller, more frequent meals.
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