Take orally, preferably 30-60 minutes before a meal (usually breakfast) for optimal acid suppression. Swallow the capsule whole with water; do not chew or crush.

Esomeprazole works by irreversibly blocking the H+/K+-ATPase enzyme (proton pump) in the gastric parietal cells, thereby reducing gastric acid secretion. Domperidone acts as a peripheral dopamine D2 receptor antagonist, enhancing gastrointestinal motility and reducing nausea and vomiting.

• •Hypersensitivity to Esomeprazole, Domperidone, or any excipients
• •Patients with prolactin-releasing pituitary tumor (prolactinoma)
• •Patients with moderate to severe hepatic impairment (due to domperidone)
• •Concomitant use with potent CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
• •Conditions where stimulation of gastrointestinal motility is harmful (e.g., gastrointestinal hemorrhage, mechanical obstruction, perforation)

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

In case of an overdose, symptomatic and supportive measures should be initiated. Activated charcoal may be given. Monitor cardiac function (ECG) due to the risk of QT prolongation with domperidone. There is no specific antidote.

Pregnancy: Use with caution during pregnancy only if clearly needed and the potential benefits outweigh the risks. Lactation: Domperidone is excreted in breast milk and may cause adverse effects in infants. Consult a doctor before use during breastfeeding.