Remivir
Generic Name
Remdesivir
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| remivir 5 mg injection | ৳ 2,000.00 | N/A |
Description
Overview of the medicine
Remivir (Remdesivir) is an antiviral drug used for the treatment of COVID-19 in hospitalized patients and certain high-risk non-hospitalized patients. It helps to slow down the replication of the SARS-CoV-2 virus.
Uses & Indications
Dosage
Adults
200 mg loading dose on Day 1, followed by 100 mg once daily for 4-9 days (total 5 or 10 days course).
Elderly
No specific dose adjustment required for elderly patients.
Pediatric
For patients ≥ 28 days old and ≥ 3 kg: 5 mg/kg loading dose on Day 1, followed by 2.5 mg/kg once daily for 4-9 days (total 5 or 10 days course).
Renal_impairment
Not recommended in patients with eGFR < 30 mL/min; consider benefit/risk in moderate renal impairment.
How to Take
Administered by intravenous infusion over 30-120 minutes. Must be diluted prior to use.
Mechanism of Action
Remdesivir is metabolized intracellularly to form a pharmacologically active nucleoside triphosphate metabolite. This metabolite acts as an adenosine triphosphate (ATP) analog and inhibits viral RNA-dependent RNA polymerase, leading to termination of viral RNA transcription.
Pharmacokinetics
Onset
Rapid onset due to intravenous administration.
Excretion
Primarily excreted renally (approximately 49% as metabolites, 10% as unchanged drug) and through feces (approximately 39% as metabolites).
Half life
Parent drug: approximately 1 hour; active metabolite: approximately 20-24 hours.
Absorption
Administered intravenously, providing 100% bioavailability.
Metabolism
Primarily metabolized intracellularly by carboxylesterase 1 and phosphoramidase cleavage to form the active nucleoside triphosphate. Also, metabolized by CYP enzymes.
Side Effects
Contraindications
- Hypersensitivity to remdesivir or any component of the formulation.
- Co-administration with chloroquine phosphate or hydroxychloroquine sulfate is not recommended due to potential antagonism.
Drug Interactions
Drugs affecting CYP enzymes
Potential for altered remdesivir exposure; monitor closely.
Chloroquine/Hydroxychloroquine
Avoid co-administration; may reduce antiviral activity of remdesivir.
Storage
Store at controlled room temperature (20°C to 25°C), protect from light. Reconstituted solution must be used within specified timeframes.
Overdose
There is no specific antidote for remdesivir overdose. Treatment should be supportive and directed at managing symptoms.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Limited human data available. Caution is advised during lactation; evaluate the benefit-risk for mother and infant.
Side Effects
Contraindications
- Hypersensitivity to remdesivir or any component of the formulation.
- Co-administration with chloroquine phosphate or hydroxychloroquine sulfate is not recommended due to potential antagonism.
Drug Interactions
Drugs affecting CYP enzymes
Potential for altered remdesivir exposure; monitor closely.
Chloroquine/Hydroxychloroquine
Avoid co-administration; may reduce antiviral activity of remdesivir.
Storage
Store at controlled room temperature (20°C to 25°C), protect from light. Reconstituted solution must be used within specified timeframes.
Overdose
There is no specific antidote for remdesivir overdose. Treatment should be supportive and directed at managing symptoms.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Limited human data available. Caution is advised during lactation; evaluate the benefit-risk for mother and infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
As per manufacturer's instructions, typically 24-36 months.
Availability
Available in designated hospitals and specialized pharmacies
Approval Status
DGDA approved (Emergency Use Authorization/Conditional Approval)
Patent Status
Voluntary license for generic manufacturing
Clinical Trials
Remdesivir has been evaluated in multiple clinical trials, including ACTT-1, Solidarity, and others, demonstrating efficacy in shortening recovery time and reducing disease progression in certain COVID-19 patients.
Lab Monitoring
- Liver function tests (ALT, AST, bilirubin) at baseline and daily during treatment.
- Renal function (eGFR, creatinine) periodically.
- Prothrombin time (PT) for patients with pre-existing hepatic impairment.
Doctor Notes
- Administer in a healthcare setting under close medical supervision.
- Monitor liver and renal function closely during treatment.
- Be prepared to manage potential infusion-related reactions.
Patient Guidelines
- Inform healthcare providers about all medical conditions and medications.
- Report any adverse reactions immediately.
- Complete the full course of treatment as prescribed.
Missed Dose Advice
If a dose is missed, administer it as soon as possible. Do not double the dose to make up for a missed one. Continue with the regular schedule.
Driving Precautions
Remdesivir may cause dizziness or lightheadedness in some patients. Patients should be advised to avoid driving or operating machinery if they experience these symptoms.
Lifestyle Advice
- Follow all healthcare provider instructions regarding rest and hydration.
- Maintain good hygiene to prevent further spread of infection.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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