Renopro
Generic Name
Finerenone
Manufacturer
Bayer
Country
Germany (Original Manufacturer)
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| renopro 10 mg tablet | ৳ 70.00 | ৳ 700.00 |
Description
Overview of the medicine
Renopro 10 mg Tablet contains Finerenone, a non-steroidal mineralocorticoid receptor antagonist (MRA) used to reduce the risk of sustained eGFR decline, end-stage kidney disease, cardiovascular death, non-fatal myocardial infarction, and hospitalization for heart failure in adults with chronic kidney disease (CKD) associated with type 2 diabetes.
Uses & Indications
Dosage
Adults
Initial dose is 10 mg once daily if eGFR is 25-60 mL/min/1.73m² and serum potassium is ≤ 4.8 mmol/L. If eGFR is ≥ 60 mL/min/1.73m² and serum potassium is ≤ 4.8 mmol/L, initial dose is 20 mg once daily. Max dose is 20 mg once daily.
Elderly
No specific dose adjustment is required based on age.
Renal_impairment
No dose adjustment is recommended for mild to moderate renal impairment. For severe renal impairment (eGFR < 25 mL/min/1.73m²), initiation is not recommended.
How to Take
Take orally, once daily, with or without food. Swallow the tablet whole; do not crush, chew, or split.
Mechanism of Action
Finerenone selectively blocks overactivation of the mineralocorticoid receptor (MR), which is implicated in the pathophysiology of CKD and heart failure. MR overactivation contributes to inflammation and fibrosis.
Pharmacokinetics
Onset
Within hours for pharmacodynamic effects (e.g., UACR reduction) but clinical benefits are long-term.
Excretion
Approximately 80% eliminated via feces (primarily as metabolites) and 20% via urine (mostly as metabolites).
Half life
Approximately 2-3 hours for the parent compound, 19-24 hours for the active major metabolite.
Absorption
Rapidly absorbed, absolute bioavailability is approximately 44%. Peak plasma concentration is reached within 0.5-1.25 hours.
Metabolism
Primarily metabolized by CYP3A4 (90%) and to a lesser extent by CYP2C8 (10%).
Side Effects
Contraindications
- Concomitant use with strong CYP3A4 inhibitors.
- Adrenal insufficiency.
Drug Interactions
Strong CYP3A4 inducers (e.g., Rifampicin, Carbamazepine, Phenytoin)
Significantly decrease Finerenone exposure, concomitant use not recommended.
Moderate CYP3A4 inhibitors (e.g., Erythromycin, Verapamil, Diltiazem)
Increase Finerenone exposure; dose adjustment or close monitoring may be required.
Strong CYP3A4 inhibitors (e.g., Ketoconazole, Itraconazole, Ritonavir)
Significantly increase Finerenone exposure, contraindicated.
Potassium-sparing diuretics (e.g., Spironolactone, Eplerenone, Amiloride)
Increased risk of hyperkalemia; avoid concomitant use.
Storage
Store below 30°C, in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hyperkalemia. Management includes close monitoring of potassium levels, supportive care, and consideration of calcium gluconate or insulin with glucose for severe hyperkalemia.
Pregnancy & Lactation
Pregnancy: Limited human data. Animal studies show adverse effects. Use only if potential benefit justifies potential risk to fetus. Lactation: Unknown if excreted in human milk. Advise against breastfeeding during treatment.
Side Effects
Contraindications
- Concomitant use with strong CYP3A4 inhibitors.
- Adrenal insufficiency.
Drug Interactions
Strong CYP3A4 inducers (e.g., Rifampicin, Carbamazepine, Phenytoin)
Significantly decrease Finerenone exposure, concomitant use not recommended.
Moderate CYP3A4 inhibitors (e.g., Erythromycin, Verapamil, Diltiazem)
Increase Finerenone exposure; dose adjustment or close monitoring may be required.
Strong CYP3A4 inhibitors (e.g., Ketoconazole, Itraconazole, Ritonavir)
Significantly increase Finerenone exposure, contraindicated.
Potassium-sparing diuretics (e.g., Spironolactone, Eplerenone, Amiloride)
Increased risk of hyperkalemia; avoid concomitant use.
Storage
Store below 30°C, in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hyperkalemia. Management includes close monitoring of potassium levels, supportive care, and consideration of calcium gluconate or insulin with glucose for severe hyperkalemia.
Pregnancy & Lactation
Pregnancy: Limited human data. Animal studies show adverse effects. Use only if potential benefit justifies potential risk to fetus. Lactation: Unknown if excreted in human milk. Advise against breastfeeding during treatment.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, Hospitals
Approval Status
FDA Approved
Patent Status
Patented (Bayer)
Clinical Trials
FIDELIO-DKD and FIGARO-DKD trials demonstrated Finerenone's efficacy in reducing renal and cardiovascular outcomes in patients with CKD and T2D.
Lab Monitoring
- Serum potassium levels (before initiation, 4 weeks after initiation/dose change, and periodically thereafter)
- eGFR (before initiation, 4 weeks after initiation/dose change, and periodically thereafter)
Doctor Notes
- Monitor serum potassium and eGFR closely, especially at initiation and after dose adjustments.
- Educate patients on symptoms of hyperkalemia and to avoid grapefruit.
Patient Guidelines
- Take Renopro exactly as prescribed by your doctor.
- Do not stop taking Renopro without consulting your doctor.
- Avoid grapefruit and grapefruit juice while on this medication.
- Report any symptoms of high potassium (e.g., muscle weakness, irregular heartbeat) to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses to make up for a missed dose.
Driving Precautions
No known effects on ability to drive or operate machinery. However, if you experience dizziness or fatigue, avoid driving.
Lifestyle Advice
- Maintain a healthy diet, limiting potassium-rich foods as advised by your doctor.
- Regular exercise and maintaining a healthy weight can support kidney and cardiovascular health.
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