Renopro
Generic Name
Telmisartan
Manufacturer
Medicon Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| renopro 20 mg tablet | ৳ 125.00 | ৳ 1,250.00 |
Description
Overview of the medicine
Renopro 20 mg Tablet contains Telmisartan, an Angiotensin II Receptor Blocker (ARB), used primarily to treat high blood pressure (hypertension) and to reduce the risk of cardiovascular events in patients at high risk. It works by relaxing blood vessels, allowing blood to flow more easily.
Uses & Indications
Dosage
Adults
The usual recommended starting dose is 40 mg once daily. For 20 mg, it may be used for milder cases or as titration. The dose may be increased to a maximum of 80 mg once daily if needed.
Elderly
No dosage adjustment is generally required for elderly patients.
Renal_impairment
No dosage adjustment is required for patients with mild to moderate renal impairment. For severe renal impairment or dialysis, lower starting doses may be considered, and careful monitoring is advised.
How to Take
Renopro tablet should be swallowed whole with water, with or without food, at approximately the same time each day.
Mechanism of Action
Telmisartan selectively blocks the binding of angiotensin II to the AT1 receptor in various tissues, including vascular smooth muscle and the adrenal gland. This inhibition leads to vasodilation, reduction in aldosterone secretion, and a decrease in blood pressure.
Pharmacokinetics
Onset
Antihypertensive effect starts within 3 hours; maximum effect achieved within 4-8 weeks.
Excretion
Almost exclusively excreted in feces, primarily as unchanged drug. Less than 1% excreted in urine.
Half life
Approximately 24 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 0.5 to 1 hour. Absolute bioavailability is about 42% for a 20 mg dose.
Metabolism
Primarily metabolized by conjugation to form an acylglucuronide; no cytochrome P450 involvement.
Side Effects
Contraindications
- Hypersensitivity to Telmisartan or any component of the formulation.
- Pregnancy (especially second and third trimesters).
- Lactation.
- Biliary obstructive disorders.
- Severe hepatic impairment.
- Concomitant use with aliskiren in patients with diabetes or renal impairment.
Drug Interactions
Digoxin
Increased plasma levels of digoxin.
Lithium
Increased serum lithium concentrations and toxicity.
Ramipril
Increased risk of hypotension, hyperkalemia, and renal impairment when co-administered with ACE inhibitors.
Diuretics and other antihypertensive agents
Increased hypotensive effect.
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
May reduce the antihypertensive effect and increase the risk of renal function deterioration.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
The most likely manifestation of overdose would be hypotension and tachycardia; bradycardia might occur. Treatment is symptomatic and supportive. Telmisartan is not removed by hemodialysis.
Pregnancy & Lactation
Renopro is contraindicated during the second and third trimesters of pregnancy due to risks to the fetus. It is not recommended during the first trimester. Due to the potential for adverse effects on the nursing infant, use is not recommended during lactation.
Side Effects
Contraindications
- Hypersensitivity to Telmisartan or any component of the formulation.
- Pregnancy (especially second and third trimesters).
- Lactation.
- Biliary obstructive disorders.
- Severe hepatic impairment.
- Concomitant use with aliskiren in patients with diabetes or renal impairment.
Drug Interactions
Digoxin
Increased plasma levels of digoxin.
Lithium
Increased serum lithium concentrations and toxicity.
Ramipril
Increased risk of hypotension, hyperkalemia, and renal impairment when co-administered with ACE inhibitors.
Diuretics and other antihypertensive agents
Increased hypotensive effect.
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
May reduce the antihypertensive effect and increase the risk of renal function deterioration.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
The most likely manifestation of overdose would be hypotension and tachycardia; bradycardia might occur. Treatment is symptomatic and supportive. Telmisartan is not removed by hemodialysis.
Pregnancy & Lactation
Renopro is contraindicated during the second and third trimesters of pregnancy due to risks to the fetus. It is not recommended during the first trimester. Due to the potential for adverse effects on the nursing infant, use is not recommended during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Telmisartan has been extensively studied in numerous clinical trials demonstrating its efficacy and safety in the management of hypertension and cardiovascular risk reduction, including studies like ONTARGET and TRANSCEND.
Lab Monitoring
- Serum electrolytes (especially potassium)
- Renal function (creatinine, BUN)
- Liver function tests (LFTs)
Doctor Notes
- Monitor serum potassium and renal function (creatinine, GFR) periodically, especially in patients with pre-existing renal impairment or those on concomitant potassium-sparing agents.
- Counsel patients on the importance of adherence to therapy and lifestyle modifications.
- Avoid concomitant use of NSAIDs in elderly or volume-depleted patients due to increased risk of acute renal failure.
Patient Guidelines
- Take Renopro exactly as prescribed by your doctor.
- Do not stop taking this medicine suddenly without consulting your doctor.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
- Regularly monitor your blood pressure as advised by your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Renopro may cause dizziness or drowsiness, especially at the start of treatment or when the dose is increased. Avoid driving or operating machinery if you experience these symptoms.
Lifestyle Advice
- Maintain a healthy diet low in sodium and saturated fats.
- Engage in regular physical activity.
- Limit alcohol consumption and avoid smoking.
- Manage stress effectively.
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