Renosart Plus
Generic Name
Losartan Potassium + Hydrochlorothiazide
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| renosart plus 50 mg tablet | ৳ 8.00 | N/A |
Description
Overview of the medicine
Renosart Plus is a combination medicine containing Losartan Potassium, an Angiotensin II Receptor Blocker (ARB), and Hydrochlorothiazide, a thiazide diuretic. It is used to treat high blood pressure (hypertension) and reduce the risk of cardiovascular events.
Uses & Indications
Dosage
Adults
The usual starting dose is one 50 mg/12.5 mg tablet once daily. The dosage may be adjusted based on blood pressure response, up to a maximum of 100 mg Losartan/25 mg Hydrochlorothiazide once daily.
Elderly
No initial dosage adjustment is usually necessary for elderly patients, but monitoring of renal function is advised.
Renal_impairment
Not recommended for patients with severe renal impairment (creatinine clearance <30 mL/min) or anuria. Dosage adjustment may be needed for moderate impairment.
How to Take
Renosart Plus tablets can be taken orally, with or without food. It should be taken at approximately the same time each day.
Mechanism of Action
Losartan blocks the binding of angiotensin II to the AT1 receptor, preventing vasoconstriction and aldosterone secretion, thus lowering blood pressure. Hydrochlorothiazide inhibits the sodium-chloride symporter in the distal convoluted tubule, increasing the excretion of sodium, chloride, and water, which reduces plasma volume and blood pressure.
Pharmacokinetics
Onset
Antihypertensive effect of Losartan within 6 hours; Hydrochlorothiazide within 2 hours. Full blood pressure reduction achieved in 3-6 weeks.
Excretion
Losartan and its metabolites are excreted via urine and feces. Hydrochlorothiazide is eliminated predominantly by renal excretion (unchanged).
Half life
Losartan: approximately 2 hours; active metabolite: 6-9 hours. Hydrochlorothiazide: 5.8 to 14.8 hours.
Absorption
Losartan is well-absorbed orally and undergoes significant first-pass metabolism to an active carboxylic acid metabolite (E-3174). Hydrochlorothiazide is rapidly absorbed following oral administration.
Metabolism
Losartan is metabolized hepatically (CYP2C9 and CYP3A4) to its active metabolite and other inactive metabolites. Hydrochlorothiazide is not metabolized.
Side Effects
Contraindications
- •Hypersensitivity to Losartan, Hydrochlorothiazide, or sulfonamide-derived drugs.
- •Anuria.
- •Severe renal impairment (creatinine clearance <30 mL/min).
- •Severe hepatic impairment.
- •Pregnancy (second and third trimesters).
- •Concomitant use with aliskiren in patients with diabetes mellitus.
Drug Interactions
Lithium
May increase serum lithium concentrations and lead to lithium toxicity.
Corticosteroids
Enhanced electrolyte depletion, particularly hypokalemia.
Alcohol, barbiturates, or narcotics
May potentiate orthostatic hypotension.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce the antihypertensive effect and increase the risk of renal impairment, especially in dehydrated or elderly patients.
Potassium-sparing diuretics, potassium supplements, or salt substitutes containing potassium
Increased risk of hyperkalemia.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypotension (low blood pressure), tachycardia (rapid heartbeat), and possibly bradycardia (slow heartbeat) due to Losartan. Hydrochlorothiazide overdose can lead to electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration. Management is symptomatic and supportive, including maintaining hydration and monitoring electrolytes and vital signs.
Pregnancy & Lactation
Renosart Plus is contraindicated during the second and third trimesters of pregnancy due to the risk of fetal injury or death. It is not recommended during the first trimester. It is not known whether Losartan is excreted in human milk, but Hydrochlorothiazide is. Therefore, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months (typically 2-3 years from manufacturing date)
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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