Reocef
Generic Name
Cefixime
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| reocef 125 mg suspension | ৳ 87.00 | N/A |
Description
Overview of the medicine
Reocef 125 mg Suspension is an oral antibiotic belonging to the cephalosporin group, used to treat a variety of bacterial infections.
Uses & Indications
Dosage
Adults
Adults and children over 10 years or weighing more than 50 kg: 200-400 mg daily as a single dose or in two divided doses. For suspension, equivalent to 10 ml - 20 ml (2-4 teaspoonfuls) once daily or 5-10 ml (1-2 teaspoonfuls) twice daily.
Elderly
No dose adjustment required unless renal function is severely impaired.
Renal_impairment
For creatinine clearance 21-60 mL/min, 75% of standard dose. For creatinine clearance <20 mL/min, 50% of standard dose.
How to Take
Shake the suspension well before each use. Can be taken with or without food. Complete the full course of treatment as prescribed by your doctor, even if symptoms improve.
Mechanism of Action
Cefixime is a third-generation cephalosporin antibiotic. It acts by inhibiting bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Peak plasma concentrations reached within 2-6 hours after oral administration.
Excretion
Eliminated predominantly by renal excretion (approximately 50% unchanged in urine) and biliary excretion.
Half life
Average plasma half-life is 3-4 hours.
Absorption
Approximately 40-50% orally absorbed. Food slightly delays absorption but does not significantly alter the extent of absorption.
Metabolism
Not extensively metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to Cefixime or other cephalosporins
- History of anaphylaxis to penicillin
Drug Interactions
Warfarin
May increase prothrombin time, monitor INR closely.
Carbamazepine
Increased carbamazepine levels reported with concomitant use.
Oral Contraceptives
May reduce efficacy of oral contraceptives (though clinical significance is debatable).
Storage
Store dry powder below 30°C. After reconstitution, store at 2-8°C (do not freeze) and discard after 7-14 days (check specific product leaflet).
Overdose
Gastric lavage may be indicated; otherwise, no specific antidote. Hemodialysis or peritoneal dialysis does not remove significant quantities of cefixime from the body.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during pregnancy if clearly needed. Excreted in breast milk in small amounts; use with caution in breastfeeding mothers.
Side Effects
Contraindications
- Hypersensitivity to Cefixime or other cephalosporins
- History of anaphylaxis to penicillin
Drug Interactions
Warfarin
May increase prothrombin time, monitor INR closely.
Carbamazepine
Increased carbamazepine levels reported with concomitant use.
Oral Contraceptives
May reduce efficacy of oral contraceptives (though clinical significance is debatable).
Storage
Store dry powder below 30°C. After reconstitution, store at 2-8°C (do not freeze) and discard after 7-14 days (check specific product leaflet).
Overdose
Gastric lavage may be indicated; otherwise, no specific antidote. Hemodialysis or peritoneal dialysis does not remove significant quantities of cefixime from the body.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during pregnancy if clearly needed. Excreted in breast milk in small amounts; use with caution in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 months for unopened bottle. After reconstitution, varies (e.g., 7-14 days if refrigerated).
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials support its efficacy in various bacterial infections. Ongoing research explores its role in emerging resistant strains.
Lab Monitoring
- Renal function tests (e.g., serum creatinine, BUN) in patients with pre-existing renal impairment
- INR for patients on warfarin
Doctor Notes
- Educate patients on the importance of completing the full course of antibiotics.
- Advise patients to report any signs of C. difficile colitis.
- Monitor renal function in patients with kidney impairment.
Patient Guidelines
- Take the full course of medication even if you feel better.
- Shake the suspension well before each use.
- Do not share this medication with others.
- Report any severe diarrhea or allergic reactions to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Cefixime is not known to impair the ability to drive or operate machinery. However, if you experience dizziness or headache, avoid such activities.
Lifestyle Advice
- Maintain good hydration
- Avoid alcohol during treatment (though not a direct interaction, good practice with antibiotics)
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Global Brand Names
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