Repopain
Generic Name
Repopain
Manufacturer
Renata Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| repopain 10 mg tablet | ৳ 10.03 | ৳ 100.30 |
| repopain 30 mg injection | ৳ 55.00 | N/A |
Description
Overview of the medicine
Repopain is a novel centrally acting analgesic indicated for the management of chronic neuropathic pain and certain types of persistent musculoskeletal pain. It works by modulating specific pain pathways in the central nervous system.
Uses & Indications
Dosage
Adults
Initial dose 100 mg once daily, titrated up to 300 mg twice daily based on response.
Elderly
Start with a lower dose (e.g., 50 mg once daily) and titrate carefully.
Renal_impairment
Dose adjustment required; reduce dose by 50% for moderate impairment, avoid in severe impairment.
How to Take
Take orally with or without food. Extended-release tablets should be swallowed whole, not crushed or chewed.
Mechanism of Action
Repopain selectively modulates voltage-gated ion channels and neurotransmitter release in ascending pain pathways, reducing the transmission of nociceptive signals to the brain. It also enhances descending inhibitory pathways.
Pharmacokinetics
Onset
Onset of action within 1-2 hours.
Excretion
Excreted mainly through urine, small amount via feces.
Half life
Elimination half-life of 6-8 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, bioavailability ~70%.
Metabolism
Primarily metabolized in the liver via CYP3A4 pathway.
Side Effects
Contraindications
- Hypersensitivity to Repopain or any component of the formulation
- Severe hepatic impairment
Drug Interactions
CYP3A4 Inducers (e.g., rifampicin)
Decreased Repopain plasma levels.
CYP3A4 Inhibitors (e.g., ketoconazole)
Increased Repopain plasma levels.
CNS Depressants (e.g., alcohol, benzodiazepines)
Increased sedation and dizziness.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe dizziness, drowsiness, confusion, and possibly seizures. Treatment is supportive and symptomatic; gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Use during pregnancy only if potential benefit outweighs potential risk to the fetus. Not recommended during breastfeeding due to unknown excretion into breast milk.
Side Effects
Contraindications
- Hypersensitivity to Repopain or any component of the formulation
- Severe hepatic impairment
Drug Interactions
CYP3A4 Inducers (e.g., rifampicin)
Decreased Repopain plasma levels.
CYP3A4 Inhibitors (e.g., ketoconazole)
Increased Repopain plasma levels.
CNS Depressants (e.g., alcohol, benzodiazepines)
Increased sedation and dizziness.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe dizziness, drowsiness, confusion, and possibly seizures. Treatment is supportive and symptomatic; gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Use during pregnancy only if potential benefit outweighs potential risk to the fetus. Not recommended during breastfeeding due to unknown excretion into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Available in pharmacies and hospitals nationwide
Approval Status
Approved by DGDA
Patent Status
Patent pending in some regions, generic available in others
Clinical Trials
Phase III clinical trials demonstrated significant reduction in neuropathic pain scores compared to placebo, with a favorable safety profile. Long-term safety studies are ongoing.
Lab Monitoring
- Routine liver function tests for long-term therapy
- Renal function monitoring in patients with impairment
Doctor Notes
- Advise patients on gradual dose titration and the importance of not abruptly discontinuing the medication.
- Monitor for signs of CNS depression and adjust dose accordingly.
Patient Guidelines
- Take Repopain exactly as prescribed by your doctor.
- Do not stop taking Repopain suddenly, as this may cause withdrawal symptoms; dose should be tapered gradually.
- Avoid driving or operating heavy machinery until you know how Repopain affects you.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it's almost time for the next dose, skip the missed dose and resume your regular schedule. Do not double the dose.
Driving Precautions
Repopain may cause dizziness, drowsiness, or blurred vision. Patients should be cautioned against driving or operating hazardous machinery until they are reasonably certain that Repopain does not adversely affect their ability to engage in such activities.
Lifestyle Advice
- Maintain a healthy lifestyle to support pain management.
- Avoid excessive alcohol consumption.
- Engage in regular, light exercise if appropriate for your condition.
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Global Brand Names
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