Reptylin
Generic Name
Serotalin
Manufacturer
PharmaCorp Inc.
Country
USA
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| reptylin 25 mg tablet | ৳ 1.00 | ৳ 10.00 |
Description
Overview of the medicine
Reptylin 25 mg Tablet is an antidepressant belonging to the Selective Serotonin Reuptake Inhibitor (SSRI) class. It is primarily used to treat major depressive disorder, anxiety disorders, and obsessive-compulsive disorder (OCD) by helping to restore the balance of a certain natural substance (serotonin) in the brain.
Uses & Indications
Dosage
Adults
Initial dose is 25 mg once daily. May be increased gradually to 50 mg or up to a maximum of 100 mg daily, based on patient response and tolerability. Doses greater than 50 mg should be divided (e.g., 25 mg twice daily).
Elderly
Start with a lower dose, typically 12.5 mg once daily. Adjust dose cautiously based on individual response and tolerability.
Renal_impairment
No specific dose adjustment is generally required for mild to moderate renal impairment. For severe impairment, caution is advised, and a lower starting dose (e.g., 12.5 mg) may be considered.
How to Take
Take Reptylin 25 mg Tablet orally, with or without food, preferably at the same time each day, usually in the morning or evening. Do not crush, chew, or break the tablet.
Mechanism of Action
Reptylin works by selectively inhibiting the reuptake of serotonin in the brain, thereby increasing the concentration of serotonin in the synaptic cleft. This enhanced serotonergic neurotransmission contributes to its antidepressant and anxiolytic effects.
Pharmacokinetics
Onset
Initial effects may be noticed within 1-2 weeks, but full therapeutic effect typically takes 2-4 weeks.
Excretion
Excreted predominantly in the urine (approximately 60%) and feces (approximately 30%) as metabolites.
Half life
Approximately 24-36 hours, allowing for once-daily dosing.
Absorption
Well absorbed orally, peak plasma concentrations reached within 4-8 hours. Bioavailability is approximately 80%.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C19, CYP2D6, and CYP3A4 enzymes, into inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Serotalin or any excipients of the formulation.
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing MAOI treatment.
- Concurrent use with Pimozide or Thioridazine.
Drug Interactions
MAOIs
Concomitant use is contraindicated due to the risk of Serotonin Syndrome.
Triptans
Increased risk of Serotonin Syndrome.
Warfarin
Increased risk of bleeding due to Reptylin's potential to inhibit CYP2C19, affecting warfarin metabolism.
NSAIDs/Aspirin
Increased risk of gastrointestinal bleeding.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, dizziness, drowsiness, tachycardia, tremor, and in severe cases, seizures or serotonin syndrome. Management is primarily supportive, including maintaining an open airway, cardiac monitoring, and symptomatic treatment. Gastric lavage and activated charcoal may be considered if ingested recently.
Pregnancy & Lactation
Pregnancy Category C/D. Use only if potential benefit outweighs the risk to the fetus. Exposure during late pregnancy may be associated with persistent pulmonary hypertension of the newborn (PPHN). Reptylin is excreted in human breast milk; caution should be exercised when administered to a nursing mother. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Serotalin or any excipients of the formulation.
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing MAOI treatment.
- Concurrent use with Pimozide or Thioridazine.
Drug Interactions
MAOIs
Concomitant use is contraindicated due to the risk of Serotonin Syndrome.
Triptans
Increased risk of Serotonin Syndrome.
Warfarin
Increased risk of bleeding due to Reptylin's potential to inhibit CYP2C19, affecting warfarin metabolism.
NSAIDs/Aspirin
Increased risk of gastrointestinal bleeding.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, dizziness, drowsiness, tachycardia, tremor, and in severe cases, seizures or serotonin syndrome. Management is primarily supportive, including maintaining an open airway, cardiac monitoring, and symptomatic treatment. Gastric lavage and activated charcoal may be considered if ingested recently.
Pregnancy & Lactation
Pregnancy Category C/D. Use only if potential benefit outweighs the risk to the fetus. Exposure during late pregnancy may be associated with persistent pulmonary hypertension of the newborn (PPHN). Reptylin is excreted in human breast milk; caution should be exercised when administered to a nursing mother. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Patent protected by PharmaCorp Inc.
WHO Essential Medicine
YesClinical Trials
Reptylin has undergone extensive Phase III clinical trials demonstrating significant efficacy in reducing symptoms of MDD and GAD compared to placebo. Key findings are published in the 'Journal of Clinical Psychiatry' and 'The Lancet Psychiatry'.
Lab Monitoring
- Baseline and periodic liver function tests (LFTs) are recommended, especially in patients with pre-existing hepatic impairment.
- Monitor serum sodium levels, especially in elderly patients or those on diuretics, due to the risk of hyponatremia.
Doctor Notes
- Educate patients on the delayed onset of action and the importance of continuous adherence to treatment.
- Monitor for signs of worsening depression, suicidality, or emergent neuropsychiatric symptoms, especially in younger patients.
- Emphasize gradual tapering of the dose when discontinuing treatment to minimize withdrawal symptoms.
Patient Guidelines
- Do not stop taking Reptylin abruptly without consulting your doctor, as this may lead to withdrawal symptoms.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
- Report any unusual mood changes, agitation, or suicidal thoughts to your doctor immediately.
- It may take several weeks for the full benefits of the medication to be felt.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Reptylin may cause dizziness, drowsiness, or impaired judgment, especially at the beginning of treatment. Avoid driving or operating heavy machinery until you know how this medication affects you.
Lifestyle Advice
- Avoid alcohol consumption while taking Reptylin, as it may worsen side effects.
- Maintain a healthy diet and regular exercise to support overall well-being.
- Practice stress-reduction techniques like meditation or yoga.
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