Resitone
Generic Name
Esomeprazole 20 mg Tablet
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| resitone 20 mg tablet | ৳ 6.02 | ৳ 60.20 |
Description
Overview of the medicine
Resitone 20 mg Tablet contains Esomeprazole, a proton pump inhibitor, used to reduce the amount of acid produced in the stomach. It is commonly prescribed for conditions like gastroesophageal reflux disease (GERD), stomach ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
GERD: 20 mg or 40 mg once daily for 4-8 weeks. Erosive Esophagitis Maintenance: 20 mg once daily. H. pylori eradication: 20 mg twice daily for 7-10 days (in combination therapy). Zollinger-Ellison Syndrome: 40 mg twice daily, adjusted as needed.
Elderly
No dosage adjustment is generally required for elderly patients.
Renal_impairment
No dosage adjustment is generally required for patients with renal impairment.
How to Take
Take the tablet whole with a glass of water, at least one hour before a meal. Do not chew or crush the tablet.
Mechanism of Action
Esomeprazole is a proton pump inhibitor that specifically inhibits the H+/K+-ATPase (proton pump) in the gastric parietal cells, thereby blocking the final step of acid secretion. This leads to a dose-dependent inhibition of both basal and stimulated acid secretion.
Pharmacokinetics
Onset
Within 1 hour, full effect within 2-4 days of continuous use.
Excretion
Approximately 80% is excreted as metabolites in the urine and the remainder in the feces.
Half life
Approximately 1.5 hours.
Absorption
Rapidly absorbed after oral administration, peak plasma levels occur within 1-2 hours. Bioavailability is approximately 64% after a single 20 mg dose, increasing to 89% after repeated administration.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system, primarily by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to Esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Digoxin
May increase the absorption and plasma concentration of digoxin.
Diazepam
May decrease the metabolism of diazepam, leading to increased plasma concentrations.
Warfarin
Increased INR and prothrombin time have been reported, requiring monitoring.
Clopidogrel
Esomeprazole may reduce the antiplatelet effect of clopidogrel by inhibiting its metabolism.
Methotrexate
May increase and prolong plasma levels of methotrexate and/or its metabolite, leading to potential toxicity.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and self-limiting, including gastrointestinal disturbances, headache, and drowsiness. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. It is unknown whether Esomeprazole is excreted in human milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to Esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Digoxin
May increase the absorption and plasma concentration of digoxin.
Diazepam
May decrease the metabolism of diazepam, leading to increased plasma concentrations.
Warfarin
Increased INR and prothrombin time have been reported, requiring monitoring.
Clopidogrel
Esomeprazole may reduce the antiplatelet effect of clopidogrel by inhibiting its metabolism.
Methotrexate
May increase and prolong plasma levels of methotrexate and/or its metabolite, leading to potential toxicity.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and self-limiting, including gastrointestinal disturbances, headache, and drowsiness. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. It is unknown whether Esomeprazole is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Available in pharmacies, hospitals and clinics
Approval Status
Approved by regulatory authorities
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Esomeprazole has undergone extensive clinical trials demonstrating its efficacy and safety in various acid-related disorders. Studies have shown superior acid suppression and healing rates compared to other PPIs in some conditions.
Lab Monitoring
- Periodic monitoring of magnesium levels is recommended for patients on long-term therapy, especially when taken with other drugs that can cause hypomagnesemia.
- Consider Vitamin B12 level monitoring in long-term therapy.
Doctor Notes
- Consider lowest effective dose for shortest duration possible.
- Assess patient for risk factors of long-term PPI use.
- Exclude malignancy before starting treatment for GERD symptoms.
Patient Guidelines
- Take as directed by your doctor, usually once daily before a meal.
- Do not stop taking the medicine suddenly without consulting your doctor, even if you feel better.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
- Seek medical attention if symptoms persist or worsen.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Resitone 20 mg Tablet is generally not expected to affect the ability to drive or operate machinery. However, if you experience dizziness or visual disturbances, you should avoid such activities.
Lifestyle Advice
- Avoid foods and drinks that trigger acid reflux, such as spicy foods, fatty foods, caffeine, and alcohol.
- Eat smaller, more frequent meals.
- Avoid lying down immediately after eating.
- Elevate the head of your bed.
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