Resitone
Generic Name
Telmisartan
Manufacturer
Medix Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| resitone 40 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Resitone 40 mg Tablet contains Telmisartan, an angiotensin II receptor blocker (ARB) used to treat high blood pressure (hypertension) and to reduce the risk of cardiovascular events in patients at high risk.
Uses & Indications
Dosage
Adults
The usual recommended dose is 40 mg once daily. Dosage may be increased to a maximum of 80 mg once daily if needed.
Elderly
No dosage adjustment is generally needed for elderly patients.
Renal_impairment
No dosage adjustment is generally needed for patients with mild to moderate renal impairment. For severe impairment, caution is advised.
How to Take
Resitone 40 mg Tablet should be taken orally once daily, with or without food. It is recommended to take it at the same time each day.
Mechanism of Action
Telmisartan selectively blocks the binding of angiotensin II to the AT1 receptor, which is responsible for the vasoconstrictor and aldosterone-secreting effects of angiotensin II. This leads to vasodilation, reduction in aldosterone secretion, and ultimately a decrease in blood pressure.
Pharmacokinetics
Onset
Within 3 hours; peak effect within 4-8 hours.
Excretion
Almost exclusively excreted in feces (more than 97%) via bile.
Half life
Approximately 24 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; absolute bioavailability is about 50%.
Metabolism
Primarily metabolized by conjugation to form an acylglucuronide (inactive metabolite).
Side Effects
Contraindications
- Hypersensitivity to the active substance or to any of the excipients.
- Pregnancy (second and third trimesters).
- Biliary obstructive disorders.
- Severe hepatic impairment.
- Concomitant use with aliskiren in patients with diabetes mellitus or renal impairment (GFR < 60 mL/min/1.73 m²).
Drug Interactions
Lithium
Increased serum lithium concentrations and toxicity have been reported.
Diuretics and other antihypertensive agents
May enhance the hypotensive effect.
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
May reduce the antihypertensive effect and increase the risk of renal impairment.
Potassium-sparing diuretics, potassium supplements, salt substitutes containing potassium
May lead to increased serum potassium levels (hyperkalemia).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited data are available concerning overdosage in humans. The most likely manifestations would be hypotension, dizziness, and tachycardia or bradycardia. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Not recommended during the first trimester of pregnancy and contraindicated during the second and third trimesters. It is not known whether Telmisartan is excreted in human milk, so caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to the active substance or to any of the excipients.
- Pregnancy (second and third trimesters).
- Biliary obstructive disorders.
- Severe hepatic impairment.
- Concomitant use with aliskiren in patients with diabetes mellitus or renal impairment (GFR < 60 mL/min/1.73 m²).
Drug Interactions
Lithium
Increased serum lithium concentrations and toxicity have been reported.
Diuretics and other antihypertensive agents
May enhance the hypotensive effect.
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
May reduce the antihypertensive effect and increase the risk of renal impairment.
Potassium-sparing diuretics, potassium supplements, salt substitutes containing potassium
May lead to increased serum potassium levels (hyperkalemia).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited data are available concerning overdosage in humans. The most likely manifestations would be hypotension, dizziness, and tachycardia or bradycardia. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Not recommended during the first trimester of pregnancy and contraindicated during the second and third trimesters. It is not known whether Telmisartan is excreted in human milk, so caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Key trials include ONTARGET (Ongoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial) and TRANSCEND (Telmisartan Randomised Assessment Study in ACE intolerant subjects with cardiovascular Disease). These trials demonstrated Telmisartan's efficacy in cardiovascular risk reduction.
Lab Monitoring
- Serum electrolytes (especially potassium)
- Renal function (BUN, creatinine, GFR)
Doctor Notes
- Regularly monitor blood pressure, renal function, and serum electrolytes.
- Counsel patients on the importance of adherence and lifestyle modifications.
- Avoid concomitant use with NSAIDs in elderly or renally impaired patients due to increased risk of renal dysfunction.
Patient Guidelines
- Take your medicine regularly as prescribed, even if you feel well.
- Do not stop taking the medicine without consulting your doctor.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness or drowsiness, especially at the start of treatment or when the dose is increased. Exercise caution when driving or operating machinery.
Lifestyle Advice
- Maintain a healthy diet low in sodium.
- Engage in regular physical activity.
- Avoid smoking and limit alcohol intake.
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