Respira
Generic Name
Desloratadine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| respira 1 mg syrup | ৳ 38.00 | N/A |
Description
Overview of the medicine
Respira 1 mg Syrup is an antihistamine used to relieve allergy symptoms such as sneezing, runny nose, itchy eyes, and hives. It works by blocking histamine, a natural substance that the body produces during an allergic reaction.
Uses & Indications
Dosage
Adults
Adults and adolescents 12 years and older: 5 mg (10 ml) once daily.
Elderly
No specific dosage adjustment needed, but caution with comorbidities.
Renal_impairment
Severe renal impairment: 5 mg (10 ml) every other day.
How to Take
Respira syrup can be taken with or without food. Use a measuring spoon or oral syringe for accurate dosing.
Mechanism of Action
Desloratadine, the active metabolite of loratadine, is a non-sedating, long-acting histamine antagonist with selective peripheral H1-receptor antagonist activity. It inhibits the release of histamine from mast cells and reduces inflammatory mediators.
Pharmacokinetics
Onset
Symptomatic relief usually occurs within 30-60 minutes.
Excretion
Eliminated equally in urine and feces, primarily as conjugated metabolites.
Half life
Approximately 27 hours.
Absorption
Rapidly absorbed after oral administration, reaching peak plasma concentrations in approximately 3 hours.
Metabolism
Extensively metabolized in the liver to 3-hydroxydesloratadine, an active metabolite, via hydroxylation followed by glucuronidation. CYP2D6 is involved.
Side Effects
Contraindications
- Hypersensitivity to desloratadine, loratadine, or any component of the formulation.
- Severe kidney or liver disease (requires dose adjustment).
Drug Interactions
Cimetidine
Increased plasma levels of desloratadine reported.
Erythromycin
Increased plasma levels of desloratadine reported, but no clinically significant ECG changes.
Ketoconazole
Increased plasma levels of desloratadine reported, but no clinically significant ECG changes.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, tachycardia, and headache. In case of overdose, symptomatic and supportive treatment should be initiated. Activated charcoal may be considered.
Pregnancy & Lactation
Use during pregnancy is not recommended unless the potential benefits outweigh the potential risks. Desloratadine is excreted in breast milk; therefore, a decision should be made whether to discontinue nursing or to discontinue the drug.
Side Effects
Contraindications
- Hypersensitivity to desloratadine, loratadine, or any component of the formulation.
- Severe kidney or liver disease (requires dose adjustment).
Drug Interactions
Cimetidine
Increased plasma levels of desloratadine reported.
Erythromycin
Increased plasma levels of desloratadine reported, but no clinically significant ECG changes.
Ketoconazole
Increased plasma levels of desloratadine reported, but no clinically significant ECG changes.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, tachycardia, and headache. In case of overdose, symptomatic and supportive treatment should be initiated. Activated charcoal may be considered.
Pregnancy & Lactation
Use during pregnancy is not recommended unless the potential benefits outweigh the potential risks. Desloratadine is excreted in breast milk; therefore, a decision should be made whether to discontinue nursing or to discontinue the drug.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of desloratadine for the relief of allergic rhinitis and chronic idiopathic urticaria symptoms.
Lab Monitoring
- No routine laboratory monitoring is typically required.
- Liver function tests may be considered in patients with pre-existing hepatic impairment.
Doctor Notes
- Advise patients on appropriate dosage for age and condition.
- Counsel on non-sedating nature but warn about individual variability.
- Emphasize not to exceed recommended dose.
Patient Guidelines
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
- Avoid alcohol consumption while taking this medication as it may worsen drowsiness.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Desloratadine is generally non-sedating, but individual responses vary. If you experience drowsiness, dizziness, or impaired vision, avoid driving or operating machinery.
Lifestyle Advice
- Avoid known allergens that trigger your symptoms.
- Maintain good hydration.
- Consider using saline nasal sprays for congestion relief if needed.
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