Reumacid
Generic Name
Indomethacin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| reumacid 100 mg suppository | ৳ 9.00 | N/A |
Description
Overview of the medicine
Indomethacin is a non-steroidal anti-inflammatory drug (NSAID) used to treat pain, fever, and inflammation. It is commonly prescribed for conditions like arthritis, gout, and ankylosing spondylitis.
Uses & Indications
Dosage
Adults
Typically 25 mg 2-3 times daily, increasing to 50 mg 2-3 times daily if needed. Maximum 200 mg/day.
Elderly
Lower doses may be required due to increased risk of side effects.
Renal_impairment
Use with caution; dose reduction may be necessary.
How to Take
Take with food or milk to reduce gastrointestinal upset.
Mechanism of Action
Inhibits cyclooxygenase (COX-1 and COX-2) enzymes, leading to reduced prostaglandin synthesis.
Pharmacokinetics
Onset
Within 30 minutes to 2 hours.
Excretion
Mainly via urine (60%) and feces (33%) as metabolites.
Half life
Approximately 4-6 hours.
Absorption
Rapidly and completely absorbed from the GI tract.
Metabolism
Primarily in the liver by O-demethylation and N-deacylation, followed by glucuronidation.
Side Effects
Contraindications
- Hypersensitivity to indomethacin or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe heart failure
- Third trimester of pregnancy
- Severe renal or hepatic impairment
Drug Interactions
Lithium
Increased lithium levels.
Diuretics
Reduced diuretic and antihypertensive effects.
Methotrexate
Increased methotrexate toxicity.
Anticoagulants
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, epigastric pain, headache, dizziness. Treatment is symptomatic and supportive; gastric lavage or activated charcoal may be considered.
Pregnancy & Lactation
Avoid in late pregnancy due to risk of premature closure of ductus arteriosus. Use with caution during lactation; small amounts may pass into breast milk.
Side Effects
Contraindications
- Hypersensitivity to indomethacin or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe heart failure
- Third trimester of pregnancy
- Severe renal or hepatic impairment
Drug Interactions
Lithium
Increased lithium levels.
Diuretics
Reduced diuretic and antihypertensive effects.
Methotrexate
Increased methotrexate toxicity.
Anticoagulants
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, epigastric pain, headache, dizziness. Treatment is symptomatic and supportive; gastric lavage or activated charcoal may be considered.
Pregnancy & Lactation
Avoid in late pregnancy due to risk of premature closure of ductus arteriosus. Use with caution during lactation; small amounts may pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory bodies (e.g., DGDA, FDA)
Patent Status
Generic available, patent expired
Clinical Trials
Extensive clinical trials support efficacy in inflammatory conditions and pain. Post-market surveillance continues to monitor safety.
Lab Monitoring
- Complete blood count (CBC)
- Renal function tests (creatinine, BUN)
- Liver function tests
- Blood pressure
Doctor Notes
- Monitor renal function, blood pressure, and CBC in patients on long-term therapy.
- Consider gastroprotective agents for high-risk patients.
- Use the lowest effective dose for the shortest possible duration.
Patient Guidelines
- Do not exceed the prescribed dose.
- Report any unusual bleeding or stomach pain.
- Avoid alcohol while taking this medicine.
- Take with food or milk to minimize GI upset.
Missed Dose Advice
Take the missed dose as soon as you remember, unless it's almost time for your next dose. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness; avoid driving or operating machinery until you know how it affects you.
Lifestyle Advice
- Maintain a healthy diet.
- Engage in regular, moderate exercise (as advised by physician).
- Avoid smoking.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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