Reumazin
Generic Name
Aceclofenac
Manufacturer
Renata Limited
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| reumazin 500 mg tablet | ৳ 5.20 | ৳ 52.00 |
Description
Overview of the medicine
Reumazin (Aceclofenac) is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
Uses & Indications
Dosage
Adults
100 mg twice daily, preferably with or after food.
Elderly
No dosage adjustment is generally required, but caution is advised due to increased risk of side effects.
Renal_impairment
Initial dose 100 mg once daily, with careful monitoring.
How to Take
Take orally with a glass of water, with or after food to minimize gastrointestinal upset.
Mechanism of Action
Aceclofenac acts primarily by inhibiting prostaglandin synthesis, by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, leading to reduced inflammation, pain, and fever.
Pharmacokinetics
Onset
Onset of action typically within 30 minutes to 1 hour.
Excretion
About two-thirds of the dose is excreted in the urine and one-third in the faeces as metabolites.
Half life
Approximately 4-4.3 hours.
Absorption
Well absorbed orally, reaching peak plasma concentrations in 1.25 to 3 hours.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C9, into 4'-hydroxyaceclofenac and other metabolites.
Side Effects
Contraindications
- Hypersensitivity to aceclofenac or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
Increased plasma lithium levels.
Warfarin
Increased risk of bleeding.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Diuretics and ACE inhibitors
Reduced hypotensive effect and increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms include headache, nausea, vomiting, epigastric pain, gastrointestinal bleeding. Management includes supportive and symptomatic treatment, gastric lavage, activated charcoal.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy due to risk of premature closure of ductus arteriosus. Use with caution in first and second trimesters if benefits outweigh risks. Avoid during lactation.
Side Effects
Contraindications
- Hypersensitivity to aceclofenac or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
Increased plasma lithium levels.
Warfarin
Increased risk of bleeding.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Diuretics and ACE inhibitors
Reduced hypotensive effect and increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms include headache, nausea, vomiting, epigastric pain, gastrointestinal bleeding. Management includes supportive and symptomatic treatment, gastric lavage, activated charcoal.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy due to risk of premature closure of ductus arteriosus. Use with caution in first and second trimesters if benefits outweigh risks. Avoid during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Numerous clinical trials have established the efficacy and safety of aceclofenac in various inflammatory conditions.
Lab Monitoring
- Liver function tests (LFTs)
- Renal function tests (RFTs)
- Complete blood count (CBC)
Doctor Notes
- Monitor renal and hepatic function, especially in elderly and patients with pre-existing conditions.
- Prescribe the lowest effective dose for the shortest duration necessary.
- Advise patients on signs of GI bleeding or cardiovascular events.
Patient Guidelines
- Take as directed by your doctor.
- Do not exceed the recommended dose.
- Report any stomach pain, black stools, or unusual bleeding.
- Avoid alcohol while on this medication.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it's almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a healthy diet and regular exercise.
- Avoid smoking.
- Limit alcohol intake.
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Global Brand Names
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