Revira
Generic Name
Paracetamol 1 gm
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| revira 1 gm tablet | ৳ 75.22 | ৳ 451.32 |
Description
Overview of the medicine
Paracetamol is a widely used over-the-counter analgesic (pain reliever) and antipyretic (fever reducer). It is commonly used for the relief of fever, headaches, muscle aches, arthritis, backaches, toothaches, colds, and menstrual cramps.
Uses & Indications
Dosage
Adults
1 gm every 4-6 hours as needed. Maximum 4 gm in 24 hours.
Elderly
No specific dosage adjustment usually needed, but caution with liver/kidney impairment.
Renal_impairment
Dosage interval may need to be extended in severe impairment (e.g., creatinine clearance <10 mL/min).
How to Take
Oral administration. Can be taken with or without food.
Mechanism of Action
Paracetamol is believed to work primarily by inhibiting prostaglandin synthesis in the central nervous system, which helps to reduce pain and fever. Its exact mechanism in relieving pain is not fully understood, but it is thought to involve effects on endogenous cannabinoid systems and serotonergic pathways.
Pharmacokinetics
Onset
30-60 minutes for analgesia, 30 minutes for antipyresis.
Excretion
Excreted in the urine primarily as glucuronide and sulfate conjugates. Less than 5% is excreted unchanged.
Half life
1.25 to 3 hours in adults, slightly longer in neonates and patients with cirrhosis.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 30-60 minutes after oral administration.
Metabolism
Primarily metabolized in the liver by conjugation with glucuronic acid and sulfate. A small amount is metabolized by cytochrome P450 enzymes to a highly reactive intermediate (N-acetyl-p-benzoquinone imine, NAPQI), which is detoxified by conjugation with glutathione.
Side Effects
Contraindications
- Hypersensitivity to paracetamol or any component of the formulation
- Severe hepatic impairment or active liver disease
- Glucose-6-phosphate dehydrogenase deficiency
Drug Interactions
Alcohol
Increased risk of liver damage.
Warfarin
May increase the anticoagulant effect, leading to bleeding.
Phenobarbital, Carbamazepine, Phenytoin
May increase paracetamol metabolism, potentially reducing efficacy and increasing hepatotoxicity risk.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, abdominal pain, and liver failure. Treatment involves gastric lavage, activated charcoal, and intravenous N-acetylcysteine (NAC) within 8 hours of overdose.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation at recommended doses, but always consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to paracetamol or any component of the formulation
- Severe hepatic impairment or active liver disease
- Glucose-6-phosphate dehydrogenase deficiency
Drug Interactions
Alcohol
Increased risk of liver damage.
Warfarin
May increase the anticoagulant effect, leading to bleeding.
Phenobarbital, Carbamazepine, Phenytoin
May increase paracetamol metabolism, potentially reducing efficacy and increasing hepatotoxicity risk.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, abdominal pain, and liver failure. Treatment involves gastric lavage, activated charcoal, and intravenous N-acetylcysteine (NAC) within 8 hours of overdose.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation at recommended doses, but always consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA and international regulatory bodies
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of paracetamol for pain and fever, often compared against placebos or other analgesics.
Lab Monitoring
- Liver function tests (in prolonged use or overdose)
- Renal function tests (in prolonged use with renal impairment)
Doctor Notes
- Advise patients about the risk of liver damage with overdose.
- Caution in patients with chronic alcohol use or pre-existing liver disease.
- Monitor for signs of allergic reactions, particularly skin rashes.
- Ensure patients are aware not to combine with other paracetamol products.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid concurrent use with other paracetamol-containing products.
- Consult a doctor if symptoms persist for more than 3-5 days.
- Keep out of reach of children.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not double doses.
Driving Precautions
Generally safe, no known impairment of driving ability.
Lifestyle Advice
- Maintain adequate hydration.
- Avoid alcohol consumption during treatment.
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Global Brand Names
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