Revira
Generic Name
Levofloxacin 500 mg
Manufacturer
MediCorp Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| revira 500 mg tablet | ৳ 40.27 | ৳ 402.70 |
Description
Overview of the medicine
Revira 500 mg Tablet is a broad-spectrum antibiotic used to treat various bacterial infections, including respiratory tract infections, urinary tract infections, skin and soft tissue infections, and some sexually transmitted infections. It belongs to the fluoroquinolone class of antibiotics.
Uses & Indications
Dosage
Adults
Typically 500 mg once daily for 7-14 days, depending on the infection. For specific infections, duration may vary.
Elderly
No dose adjustment is necessary for elderly patients with normal renal function.
Renal_impairment
Dose adjustment required. For CrCl 20-49 mL/min, initial 500 mg, then 250 mg daily. For CrCl 10-19 mL/min, initial 500 mg, then 250 mg every 2 days.
How to Take
Revira tablets can be taken with or without food. It should be swallowed whole with a sufficient amount of liquid. Do not crush, chew, or break the tablet.
Mechanism of Action
Levofloxacin, the active ingredient in Revira, acts by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination. This leads to disruption of bacterial DNA processes and ultimately bacterial cell death, exhibiting a bactericidal effect.
Pharmacokinetics
Onset
Within 1-2 hours of administration.
Excretion
Primarily renal, with approximately 87% of the administered dose excreted unchanged in urine within 48 hours.
Half life
Approximately 6-8 hours.
Absorption
Rapid and complete absorption after oral administration; peak plasma concentrations reached within 1-2 hours.
Metabolism
Minimally metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to levofloxacin, other quinolones, or any excipients of the tablet
- History of tendinitis or tendon rupture associated with fluoroquinolone use
- Epilepsy or other seizure disorders
- Children and adolescents below 18 years of age (due to risk of joint damage)
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin, requiring INR monitoring.
Corticosteroids
Increased risk of tendon disorders, especially in elderly patients.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May increase the risk of CNS stimulation and convulsive seizures.
Antacids, iron supplements, sucralfate, zinc supplements
May decrease the absorption of levofloxacin. Take Revira at least 2 hours before or 2 hours after these agents.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of an overdose, symptomatic treatment and supportive measures should be initiated. Gastric lavage may be performed. Monitor ECG due to the potential for QT prolongation. Hemodialysis or peritoneal dialysis is not effective in removing levofloxacin from the body.
Pregnancy & Lactation
Revira (Levofloxacin) is generally not recommended during pregnancy or breastfeeding due to potential risks to the fetus/infant, including cartilage damage. It should only be used if the potential benefit justifies the potential risk to the fetus/infant and under strict medical supervision.
Side Effects
Contraindications
- Hypersensitivity to levofloxacin, other quinolones, or any excipients of the tablet
- History of tendinitis or tendon rupture associated with fluoroquinolone use
- Epilepsy or other seizure disorders
- Children and adolescents below 18 years of age (due to risk of joint damage)
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin, requiring INR monitoring.
Corticosteroids
Increased risk of tendon disorders, especially in elderly patients.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May increase the risk of CNS stimulation and convulsive seizures.
Antacids, iron supplements, sucralfate, zinc supplements
May decrease the absorption of levofloxacin. Take Revira at least 2 hours before or 2 hours after these agents.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of an overdose, symptomatic treatment and supportive measures should be initiated. Gastric lavage may be performed. Monitor ECG due to the potential for QT prolongation. Hemodialysis or peritoneal dialysis is not effective in removing levofloxacin from the body.
Pregnancy & Lactation
Revira (Levofloxacin) is generally not recommended during pregnancy or breastfeeding due to potential risks to the fetus/infant, including cartilage damage. It should only be used if the potential benefit justifies the potential risk to the fetus/infant and under strict medical supervision.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory bodies
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Levofloxacin for approved indications. Post-marketing surveillance continues to monitor for rare adverse events.
Lab Monitoring
- Renal function tests (especially in patients with pre-existing renal impairment)
- Liver function tests (in patients with hepatic impairment or during prolonged treatment)
- Complete blood count (for prolonged treatment)
Doctor Notes
- Always inquire about previous adverse reactions to quinolones.
- Counsel patients on immediate discontinuation and seeking medical attention for symptoms of tendinitis/tendon rupture or neurological adverse effects.
- Consider drug interactions, especially with antacids, iron, and warfarin.
Patient Guidelines
- Complete the entire course of medication as prescribed by your doctor, even if you feel better.
- Drink plenty of fluids to prevent crystalluria.
- Avoid excessive exposure to sunlight or artificial UV light, as it may cause photosensitivity.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Revira may cause dizziness, lightheadedness, or visual disturbances. Patients should be advised to know how they react to Revira before driving or operating machinery.
Lifestyle Advice
- Report any unusual pain, numbness, tingling, or weakness in your extremities immediately to your doctor.
- Avoid consuming dairy products or calcium-fortified juices at the same time as taking this medication.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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