Revlixen
Generic Name
Serotonium Hydrochloride 10 mg capsule
Manufacturer
PharmaCorp Bangladesh Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| revlixen 10 mg capsule | ৳ 200.00 | ৳ 1,400.00 |
Description
Overview of the medicine
Revlixen 10 mg capsule is an antidepressant medication used to treat various mental health conditions including major depressive disorder, generalized anxiety disorder, and panic disorder. It works by helping to restore the balance of a certain natural substance (serotonin) in the brain.
Uses & Indications
Dosage
Adults
Initial dose 10 mg once daily, may be increased to a maximum of 20 mg daily after 2 weeks, based on patient response and tolerability.
Elderly
Starting dose 5 mg once daily, gradually increased if needed. Maximum recommended dose 10 mg daily.
Renal_impairment
No dose adjustment typically required for mild to moderate impairment. Use with caution in severe impairment; consider lower starting dose.
How to Take
Take orally once daily, in the morning or evening, with or without food. Swallow the capsule whole with water. Do not chew or crush.
Mechanism of Action
Revlixen selectively inhibits the reuptake of serotonin (5-HT) by presynaptic neurons in the central nervous system. This leads to an increase in the concentration of serotonin in the synaptic cleft, thereby enhancing serotonergic neurotransmission and improving mood and anxiety symptoms.
Pharmacokinetics
Onset
Initial therapeutic effects may be observed within 1-2 weeks, full effect in 4-6 weeks.
Excretion
Excreted primarily through urine (metabolites) and feces.
Half life
Approximately 24-36 hours.
Absorption
Well absorbed after oral administration, peak plasma concentrations reached within 4-8 hours.
Metabolism
Extensively metabolized in the liver, primarily by cytochrome P450 enzymes (e.g., CYP2D6, CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to Serotonium Hydrochloride or any excipients
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing MAOI therapy
- Severe liver impairment
- Concomitant use with Pimozide
Drug Interactions
MAOIs
Increased risk of serotonin syndrome; contraindicated.
NSAIDs
Increased risk of gastrointestinal bleeding.
Triptans
Increased risk of serotonin syndrome.
Warfarin
May increase anticoagulant effect and risk of bleeding; monitor INR.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, dizziness, tremor, somnolence, and rarely, seizures or serotonin syndrome. Treatment is symptomatic and supportive. Maintain an open airway, monitor cardiac and vital signs. Activated charcoal may be considered if ingested recently.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding due to potential excretion into breast milk; consider alternative treatment or discontinue breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to Serotonium Hydrochloride or any excipients
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing MAOI therapy
- Severe liver impairment
- Concomitant use with Pimozide
Drug Interactions
MAOIs
Increased risk of serotonin syndrome; contraindicated.
NSAIDs
Increased risk of gastrointestinal bleeding.
Triptans
Increased risk of serotonin syndrome.
Warfarin
May increase anticoagulant effect and risk of bleeding; monitor INR.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, dizziness, tremor, somnolence, and rarely, seizures or serotonin syndrome. Treatment is symptomatic and supportive. Maintain an open airway, monitor cardiac and vital signs. Activated charcoal may be considered if ingested recently.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding due to potential excretion into breast milk; consider alternative treatment or discontinue breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA and FDA
Patent Status
Patent pending
Clinical Trials
Revlixen has undergone extensive Phase III clinical trials demonstrating its efficacy and safety in the treatment of major depressive disorder and anxiety disorders. Further post-marketing surveillance is ongoing.
Lab Monitoring
- Monitor liver function tests periodically, especially in patients with pre-existing hepatic impairment.
- Monitor serum sodium levels in patients at risk of hyponatremia.
- Regularly assess for clinical worsening and suicidality.
Doctor Notes
- Emphasize gradual tapering when discontinuing treatment to prevent withdrawal symptoms.
- Monitor for suicidal ideation, especially at the initiation of therapy or dose changes, particularly in young patients.
- Assess for potential drug-drug interactions, particularly with MAOIs, Warfarin, and other serotonergic agents.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking Revlixen suddenly, as this can lead to withdrawal symptoms; gradual tapering is necessary under medical supervision.
- Inform your doctor if you experience any unusual changes in mood or behavior, or develop new or worsening symptoms.
- Avoid alcohol consumption while on this medication.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Revlixen may cause dizziness, drowsiness, or visual disturbances. Patients should be cautioned about operating hazardous machinery or driving until they are reasonably certain that Revlixen does not adversely affect their ability to engage in such activities.
Lifestyle Advice
- Engage in regular physical activity to help manage mood and stress.
- Maintain a balanced diet and ensure adequate sleep.
- Practice relaxation techniques such as meditation or deep breathing.
- Seek support from family, friends, or support groups.
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