Revlixen
Generic Name
Immunomodulator X-25
Manufacturer
MediCo Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| revlixen 25 mg capsule | ৳ 400.00 | ৳ 2,800.00 |
Description
Overview of the medicine
Revlixen 25 mg Capsule is an immunomodulating agent used in the management of certain autoimmune conditions. It works by targeting specific pathways involved in inflammation and immune response, thereby reducing disease activity and improving patient symptoms.
Uses & Indications
Dosage
Adults
25 mg once daily, or as directed by physician.
Elderly
No specific dose adjustment is usually required, but caution is advised. Consult physician.
Renal_impairment
Dose adjustment may be necessary for severe renal impairment. Consult physician.
How to Take
Take orally, with or without food. Swallow the capsule whole; do not crush, cut, or chew.
Mechanism of Action
Revlixen selectively inhibits Janus Kinase (JAK) enzymes, particularly JAK1 and JAK2, which are crucial in the signaling pathways of various cytokines and growth factors involved in inflammatory and immune responses. By blocking these pathways, Revlixen modulates the immune system and reduces inflammation.
Pharmacokinetics
Onset
Clinical effects may be observed within 2-4 weeks, with full effect taking up to 3 months.
Excretion
Excreted primarily through urine (70%) and feces (30%).
Half life
Approximately 4-6 hours.
Absorption
Rapidly absorbed after oral administration, peak plasma concentration reached within 1-2 hours.
Metabolism
Primarily metabolized in the liver by cytochrome P450 enzymes (CYP3A4 and CYP2D6).
Side Effects
Contraindications
- Hypersensitivity to the active substance or any excipients.
- Severe active infections (e.g., tuberculosis, severe fungal infections).
Drug Interactions
Strong CYP3A4 inducers (e.g., rifampicin)
May decrease Revlixen exposure, potentially reducing efficacy.
Strong CYP3A4 inhibitors (e.g., ketoconazole)
May increase Revlixen exposure, necessitating dose adjustment.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
In case of overdose, seek immediate medical attention. Management is supportive and symptomatic; hemodialysis may be considered if necessary.
Pregnancy & Lactation
Not recommended during pregnancy due to potential fetal harm. Women of childbearing potential should use effective contraception. Avoid breastfeeding during treatment and for at least 18 days after the last dose.
Side Effects
Contraindications
- Hypersensitivity to the active substance or any excipients.
- Severe active infections (e.g., tuberculosis, severe fungal infections).
Drug Interactions
Strong CYP3A4 inducers (e.g., rifampicin)
May decrease Revlixen exposure, potentially reducing efficacy.
Strong CYP3A4 inhibitors (e.g., ketoconazole)
May increase Revlixen exposure, necessitating dose adjustment.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
In case of overdose, seek immediate medical attention. Management is supportive and symptomatic; hemodialysis may be considered if necessary.
Pregnancy & Lactation
Not recommended during pregnancy due to potential fetal harm. Women of childbearing potential should use effective contraception. Avoid breastfeeding during treatment and for at least 18 days after the last dose.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent Protected
Clinical Trials
Revlixen has undergone extensive clinical trials demonstrating its efficacy and safety in indicated autoimmune conditions. Details can be found on clinical trial registries.
Lab Monitoring
- Complete Blood Count (CBC) including lymphocyte count, at baseline and periodically.
- Liver function tests (LFTs) at baseline and periodically.
Doctor Notes
- Prior to initiation, screen patients for tuberculosis and viral hepatitis.
- Monitor lipid parameters and CBC at regular intervals during therapy.
Patient Guidelines
- Do not stop taking Revlixen without consulting your doctor.
- Report any signs of infection (fever, chills, persistent cough) immediately.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Revlixen may cause dizziness in some patients. Patients should exercise caution when driving or operating machinery until they know how the medicine affects them.
Lifestyle Advice
- Maintain good hygiene to reduce infection risk.
- Avoid live vaccines while on Revlixen treatment.
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