Rinofen
Generic Name
Fexofenadine Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rinofen 180 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Rinofen 180 mg tablet contains Fexofenadine Hydrochloride, a non-sedating antihistamine used to relieve symptoms of seasonal allergic rhinitis and chronic idiopathic urticaria.
Uses & Indications
Dosage
Adults
For seasonal allergic rhinitis and chronic idiopathic urticaria, 180 mg once daily.
Elderly
No specific dose adjustment is generally required in elderly patients, but caution is advised in those with renal impairment.
Renal_impairment
For moderate to severe renal impairment, an initial dose of 60 mg once daily is recommended.
How to Take
Administer Rinofen 180 mg orally, preferably with water, before a meal. Do not take with fruit juice.
Mechanism of Action
Fexofenadine is a selective peripheral H1-receptor antagonist. It effectively inhibits histamine release and reduces allergic symptoms without causing significant drowsiness due to its poor ability to cross the blood-brain barrier.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Primarily excreted unchanged, 80% in feces and 10-20% in urine.
Half life
11-15 hours
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached in 1-3 hours. Absolute bioavailability is approximately 33%.
Metabolism
Minimally metabolized in the liver (approximately 5% of the dose is metabolized).
Side Effects
Contraindications
- Hypersensitivity to fexofenadine hydrochloride or any of the excipients.
- Children under 12 years of age for the 180 mg strength.
Drug Interactions
Erythromycin, Ketoconazole
May lead to increased plasma concentrations of fexofenadine, though generally not considered clinically significant.
Antacids (containing aluminum or magnesium)
Can reduce the absorption of fexofenadine. Separate administration by at least 2 hours.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms may include dizziness, drowsiness, and dry mouth. Treatment should be symptomatic and supportive. Hemodialysis does not effectively remove fexofenadine from blood.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Fexofenadine is excreted in breast milk; therefore, caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to fexofenadine hydrochloride or any of the excipients.
- Children under 12 years of age for the 180 mg strength.
Drug Interactions
Erythromycin, Ketoconazole
May lead to increased plasma concentrations of fexofenadine, though generally not considered clinically significant.
Antacids (containing aluminum or magnesium)
Can reduce the absorption of fexofenadine. Separate administration by at least 2 hours.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms may include dizziness, drowsiness, and dry mouth. Treatment should be symptomatic and supportive. Hemodialysis does not effectively remove fexofenadine from blood.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Fexofenadine is excreted in breast milk; therefore, caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Off-patent
Clinical Trials
Fexofenadine has been extensively studied in numerous clinical trials demonstrating its efficacy and safety for the treatment of seasonal allergic rhinitis and chronic idiopathic urticaria across various patient populations.
Lab Monitoring
- No routine laboratory monitoring is generally required for patients taking fexofenadine. If hepatic or renal impairment is suspected, liver and kidney function tests may be considered.
Doctor Notes
- Emphasize to patients the importance of avoiding fruit juices around the time of fexofenadine administration to prevent reduced bioavailability.
- Advise caution in patients with renal impairment and consider dose adjustment as per guidelines.
- Reassure patients about the non-sedating nature, but counsel on individual variability.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor.
- Do not take more than the recommended dose.
- Avoid taking this medicine with fruit juices (e.g., grapefruit, orange, apple) as they may reduce its effectiveness.
- Store in a cool, dry place away from direct light and moisture.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Fexofenadine is generally non-sedating. However, individual responses may vary. Exercise caution when driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Try to identify and avoid your allergy triggers (e.g., pollen, dust mites, pet dander).
- Maintain good indoor air quality and cleanliness in your living environment.
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