Rispolux
Generic Name
Risperidone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rispolux 2 mg tablet | ৳ 6.00 | ৳ 60.00 |
Description
Overview of the medicine
Rispolux 2 mg Tablet contains Risperidone, an atypical antipsychotic medication primarily used to treat schizophrenia, bipolar disorder (manic or mixed episodes), and irritability associated with autistic disorder. It helps restore the balance of certain natural substances in the brain.
Uses & Indications
Dosage
Adults
Schizophrenia: Initially 2 mg once daily, increase to 4-6 mg daily. Bipolar Mania: Initially 2-3 mg once daily, adjust as needed. Max 16 mg/day.
Elderly
Initially 0.5 mg twice daily, may be increased gradually. Caution due to increased sensitivity.
Renal_impairment
Initially 0.5 mg twice daily, may be increased to 1-2 mg twice daily. Dose adjustment necessary.
How to Take
Rispolux 2 mg Tablet should be taken orally, with or without food. It is usually taken once or twice daily, as directed by the physician. The tablet should be swallowed whole with water.
Mechanism of Action
Risperidone is a selective monoaminergic antagonist with high affinity for serotonin 5-HT2 and dopamine D2 receptors. It also antagonizes alpha1-adrenergic and, to a lesser extent, alpha2-adrenergic and H1-histaminergic receptors. Its antipsychotic activity is believed to be mediated through a combination of dopamine D2 and serotonin 5-HT2 antagonism.
Pharmacokinetics
Onset
Antipsychotic effects may be observed within a few days to weeks.
Excretion
Approximately 70% excreted in urine and 14% in feces, mainly as metabolites.
Half life
Mean elimination half-life is about 3 hours for risperidone and 20 hours for the active moiety (risperidone + 9-hydroxyrisperidone).
Absorption
Well absorbed after oral administration, peak plasma concentrations typically reached within 1-2 hours.
Metabolism
Extensively metabolized in the liver, primarily by CYP2D6 to 9-hydroxyrisperidone (active metabolite), and to a lesser extent by N-dealkylation.
Side Effects
Contraindications
- Known hypersensitivity to risperidone or to any of the excipients.
- Patients with severe CNS depression or coma.
Drug Interactions
Antihypertensives
May enhance hypotensive effects due to alpha-blocking activity.
CNS depressants (e.g., alcohol, benzodiazepines)
May potentiate the sedative effects of risperidone.
Strong CYP2D6 inhibitors (e.g., fluoxetine, paroxetine)
May increase plasma concentrations of risperidone and its active metabolite. Dose adjustment may be necessary.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, sedation, tachycardia, hypotension, and extrapyramidal symptoms. In severe cases, coma, seizures, and prolonged QT interval may occur. Treatment is primarily supportive; maintain airway, ensure adequate oxygenation and ventilation, and monitor cardiac function. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Risperidone is excreted in human milk, so caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Known hypersensitivity to risperidone or to any of the excipients.
- Patients with severe CNS depression or coma.
Drug Interactions
Antihypertensives
May enhance hypotensive effects due to alpha-blocking activity.
CNS depressants (e.g., alcohol, benzodiazepines)
May potentiate the sedative effects of risperidone.
Strong CYP2D6 inhibitors (e.g., fluoxetine, paroxetine)
May increase plasma concentrations of risperidone and its active metabolite. Dose adjustment may be necessary.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, sedation, tachycardia, hypotension, and extrapyramidal symptoms. In severe cases, coma, seizures, and prolonged QT interval may occur. Treatment is primarily supportive; maintain airway, ensure adequate oxygenation and ventilation, and monitor cardiac function. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Risperidone is excreted in human milk, so caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by major regulatory bodies
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of risperidone for its approved indications. Ongoing research continues to explore its use in other psychiatric conditions.
Lab Monitoring
- Fasting plasma glucose
- Lipid profile
- Weight and BMI
- Prolactin levels
- ECG (in patients at risk for arrhythmias)
Doctor Notes
- Monitor for metabolic changes (weight, glucose, lipids) regularly.
- Assess for symptoms of tardive dyskinesia periodically.
- Counsel patients on potential for orthostatic hypotension and sedation.
- Consider dose adjustments in elderly or renally impaired patients.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not stop taking the medication abruptly without consulting your doctor.
- Avoid alcohol while on this medication.
- Be aware of potential dizziness or drowsiness, especially when starting treatment.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Rispolux 2 mg Tablet may cause drowsiness, dizziness, or visual disturbances. Patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that risperidone therapy does not affect them adversely.
Lifestyle Advice
- Maintain a healthy diet and exercise regularly to manage potential weight gain.
- Avoid smoking.
- Practice good sleep hygiene.
- Attend regular follow-up appointments with your doctor.
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