Rispolux
Generic Name
Risperidone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rispolux 4 mg tablet | ৳ 9.50 | ৳ 95.00 |
Description
Overview of the medicine
Rispolux 4 mg Tablet contains Risperidone, an atypical antipsychotic used to treat schizophrenia, bipolar disorder, and irritability associated with autistic disorder.
Uses & Indications
Dosage
Adults
Schizophrenia: Initially 2 mg/day, increased to 4-6 mg/day. Bipolar mania: Initially 2-3 mg once daily, adjusted to 1-6 mg/day.
Elderly
Initially 0.5 mg twice daily, may be increased gradually. Lower starting doses and slower titration recommended.
Renal_impairment
Initial dose of 0.5 mg twice daily. Dose escalation should be slower, and the therapeutic dose should be halved.
How to Take
Take orally with or without food. It can be taken as a single dose or divided into two doses per day. Tablets should be swallowed whole with water.
Mechanism of Action
Risperidone is a selective monoaminergic antagonist with high affinity for serotonin 5-HT2 and dopamine D2 receptors. It also binds to alpha1 adrenergic and, with lower affinity, to H1 histaminergic and alpha2 adrenergic receptors. It is an antagonist at these receptors, but has no affinity for cholinergic muscarinic receptors.
Pharmacokinetics
Onset
Antipsychotic effects may be observed within a few days to weeks, with full effect achieved over several weeks.
Excretion
Excreted primarily via the kidneys (70%) and feces (14%).
Half life
Risperidone: approximately 3 hours; 9-hydroxyrisperidone (active metabolite): approximately 21 hours.
Absorption
Well absorbed after oral administration, peak plasma concentrations reached within 1-2 hours (risperidone) and 3-6 hours (9-hydroxyrisperidone).
Metabolism
Extensively metabolized in the liver, primarily by CYP2D6 to 9-hydroxyrisperidone (paliperidone), an active metabolite. Other pathways include N-dealkylation.
Side Effects
Contraindications
- Hypersensitivity to risperidone, paliperidone, or any component of the formulation.
- Severe cardiac insufficiency, recent myocardial infarction, or uncompensated heart failure.
Drug Interactions
Antihypertensives
May enhance hypotensive effects.
Drugs that prolong QT interval
Increased risk of cardiac arrhythmias.
Dopamine agonists (e.g., levodopa)
May antagonize the effects of dopamine agonists.
CYP2D6 inhibitors (e.g., fluoxetine, paroxetine)
May increase plasma concentrations of risperidone.
CNS Depressants (e.g., alcohol, opioids, benzodiazepines)
May increase sedative effects.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, sedation, tachycardia, hypotension, and extrapyramidal symptoms. Gastric lavage, activated charcoal, and supportive care are recommended.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Risperidone is excreted into breast milk; therefore, women should not breastfeed while receiving risperidone.
Side Effects
Contraindications
- Hypersensitivity to risperidone, paliperidone, or any component of the formulation.
- Severe cardiac insufficiency, recent myocardial infarction, or uncompensated heart failure.
Drug Interactions
Antihypertensives
May enhance hypotensive effects.
Drugs that prolong QT interval
Increased risk of cardiac arrhythmias.
Dopamine agonists (e.g., levodopa)
May antagonize the effects of dopamine agonists.
CYP2D6 inhibitors (e.g., fluoxetine, paroxetine)
May increase plasma concentrations of risperidone.
CNS Depressants (e.g., alcohol, opioids, benzodiazepines)
May increase sedative effects.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, sedation, tachycardia, hypotension, and extrapyramidal symptoms. Gastric lavage, activated charcoal, and supportive care are recommended.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Risperidone is excreted into breast milk; therefore, women should not breastfeed while receiving risperidone.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture.
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Off-patent (generic versions available)
WHO Essential Medicine
YesClinical Trials
Risperidone has undergone extensive clinical trials demonstrating its efficacy and safety in the treatment of schizophrenia, bipolar disorder, and other approved indications. Ongoing research continues to explore its applications and long-term effects.
Lab Monitoring
- Fasting blood glucose
- Lipid panel
- Prolactin levels
- Complete blood count (CBC)
- Liver function tests (LFTs)
- ECG (especially in patients with cardiovascular risk factors)
Doctor Notes
- Monitor patients for extrapyramidal symptoms, particularly at higher doses.
- Regularly assess for metabolic changes (weight, glucose, lipids) and prolactin levels.
- Advise patients on lifestyle modifications to mitigate metabolic risks.
Patient Guidelines
- Take your medicine regularly as prescribed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Report any new or worsening side effects to your doctor immediately.
- Avoid alcohol while taking this medicine.
- Be cautious when driving or operating machinery until you know how this medicine affects you.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Rispolux may cause drowsiness, dizziness, or blurred vision. Patients should be cautious when driving or operating machinery until they are reasonably certain that risperidone does not adversely affect their ability to perform such activities.
Lifestyle Advice
- Maintain a healthy diet and regular exercise to manage weight gain.
- Avoid smoking and illicit drug use.
- Stay hydrated and avoid excessive caffeine.
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