Robentyl
Generic Name
Dicyclomine Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| robentyl 10 mg syrup | ৳ 40.00 | N/A |
Description
Overview of the medicine
Robentyl 10 mg Syrup is an anticholinergic antispasmodic medication primarily used to treat functional bowel disorders like Irritable Bowel Syndrome (IBS). It works by relaxing the muscles of the stomach and intestine, thereby reducing muscle spasms and cramps.
Uses & Indications
Dosage
Adults
Adults: 10-20 mg (5-10 ml) three to four times daily. Maximum dose 80 mg/day.
Elderly
Elderly: Use with caution, starting with lower doses. Individualized dosage based on response and tolerance.
Renal_impairment
Renal impairment: Use with caution. Dosage adjustment may be necessary in severe impairment.
How to Take
Administer orally, preferably 30-60 minutes before meals. Can be taken with food if stomach upset occurs.
Mechanism of Action
Dicyclomine is an anticholinergic (antimuscarinic) agent that blocks the action of acetylcholine at muscarinic receptors on smooth muscles, glands, and the central nervous system. This blockage leads to relaxation of smooth muscles in the gastrointestinal tract, reducing spasms and hypermotility.
Pharmacokinetics
Onset
Typically within 1-2 hours.
Excretion
Mainly through urine (75-80%) and feces (10%).
Half life
Approximately 1.8 hours (terminal half-life).
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are achieved in about 60-90 minutes.
Metabolism
Primarily hepatic metabolism.
Side Effects
Contraindications
- Hypersensitivity to dicyclomine or any component
- Glaucoma
- Myasthenia gravis
- Obstructive uropathy
- Obstructive gastrointestinal disease (e.g., paralytic ileus, pyloric stenosis)
- Severe ulcerative colitis
- Reflux esophagitis
- Unstable cardiovascular status in acute hemorrhage
- Infants less than 6 months of age
Drug Interactions
Digoxin
May increase serum digoxin levels due to delayed gastric emptying.
Antacids
May decrease dicyclomine absorption; separate administration by at least 2 hours.
Phenothiazines
May decrease phenothiazine absorption and potentiate anticholinergic effects.
Opioid analgesics
Increased risk of severe constipation and paralytic ileus.
Other anticholinergics
Increased risk of anticholinergic side effects (e.g., dry mouth, blurred vision, constipation).
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children. Do not freeze.
Overdose
Symptoms include blurred vision, dilated pupils, dry mouth, difficulty swallowing, dizziness, nausea, vomiting, central nervous system stimulation (e.g., excitement, delirium), and rarely coma. Treatment is symptomatic and supportive; gastric lavage, activated charcoal, and physostigmine (antidote) may be considered under medical supervision.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Dicyclomine is excreted in breast milk; advise against use during lactation due to potential for adverse effects in nursing infants.
Side Effects
Contraindications
- Hypersensitivity to dicyclomine or any component
- Glaucoma
- Myasthenia gravis
- Obstructive uropathy
- Obstructive gastrointestinal disease (e.g., paralytic ileus, pyloric stenosis)
- Severe ulcerative colitis
- Reflux esophagitis
- Unstable cardiovascular status in acute hemorrhage
- Infants less than 6 months of age
Drug Interactions
Digoxin
May increase serum digoxin levels due to delayed gastric emptying.
Antacids
May decrease dicyclomine absorption; separate administration by at least 2 hours.
Phenothiazines
May decrease phenothiazine absorption and potentiate anticholinergic effects.
Opioid analgesics
Increased risk of severe constipation and paralytic ileus.
Other anticholinergics
Increased risk of anticholinergic side effects (e.g., dry mouth, blurred vision, constipation).
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children. Do not freeze.
Overdose
Symptoms include blurred vision, dilated pupils, dry mouth, difficulty swallowing, dizziness, nausea, vomiting, central nervous system stimulation (e.g., excitement, delirium), and rarely coma. Treatment is symptomatic and supportive; gastric lavage, activated charcoal, and physostigmine (antidote) may be considered under medical supervision.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Dicyclomine is excreted in breast milk; advise against use during lactation due to potential for adverse effects in nursing infants.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date, refer to packaging for exact expiry.
Availability
Pharmacies, Hospitals
Approval Status
Approved by FDA/DGDA
Patent Status
Off-patent
Clinical Trials
Numerous clinical trials have established Dicyclomine's efficacy in reducing symptoms of IBS and functional bowel disorders by alleviating smooth muscle spasms.
Lab Monitoring
- No routine lab monitoring is required. Monitor for clinical response and adverse effects.
Doctor Notes
- Counsel patients on potential anticholinergic side effects.
- Advise caution in elderly patients due to increased susceptibility to adverse effects.
- Not recommended for infants under 6 months due to risk of respiratory distress and seizures.
Patient Guidelines
- Take as directed by your doctor.
- Do not exceed the recommended dose.
- Avoid alcohol while taking this medication as it may increase drowsiness.
- Be cautious when driving or operating machinery as this medication can cause dizziness or blurred vision.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Dicyclomine may cause dizziness, drowsiness, or blurred vision. Patients should be advised not to drive or operate machinery until they know how the drug affects them.
Lifestyle Advice
- Manage stress, as it can worsen IBS symptoms.
- Maintain a balanced diet and regular exercise.
- Stay hydrated by drinking plenty of water.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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