Robentyl
Generic Name
Dicycloverine Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| robentyl 10 mg tablet | ৳ 2.00 | ৳ 20.00 |
Description
Overview of the medicine
Dicycloverine (also known as Dicyclomine) is an anticholinergic medication used to treat symptoms of irritable bowel syndrome (IBS), such as cramps, spasms, and pain in the stomach and intestines. It helps to relax the muscles of the gut.
Uses & Indications
Dosage
Adults
Oral: 10-20 mg three to four times daily. Maximum dose 80 mg/day.
Elderly
Start with lower dose (e.g., 10 mg three times daily) due to increased sensitivity to anticholinergic effects.
Renal_impairment
Use with caution. Dosage reduction may be necessary; monitor for adverse effects.
How to Take
Take orally, usually 30-60 minutes before meals. It can be taken with or without food. Swallow the tablet whole with water.
Mechanism of Action
Dicycloverine works by blocking the action of acetylcholine on muscarinic receptors located in the smooth muscle of the gastrointestinal tract, urinary tract, and other organs. This blockade leads to relaxation of smooth muscles, reducing spasms and cramping.
Pharmacokinetics
Onset
1-2 hours
Excretion
Excreted mainly via urine (80%) and feces (10%)
Half life
Approximately 1.8 hours
Absorption
Rapidly absorbed after oral administration. Peak plasma concentration reached within 1-1.5 hours.
Metabolism
Primarily hepatic metabolism
Side Effects
Contraindications
- Glaucoma
- Obstructive uropathy (e.g., prostatic hypertrophy)
- Gastrointestinal obstruction
- Paralytic ileus
- Severe ulcerative colitis or toxic megacolon
- Myasthenia gravis
- Infants under 6 months
Drug Interactions
Digoxin
May increase serum digoxin levels due to delayed gastric emptying.
Antacids
May decrease the absorption of Dicycloverine. Separate administration by at least 2 hours.
Other Anticholinergics (e.g., tricyclic antidepressants, antihistamines)
Increased risk of anticholinergic side effects (e.g., dry mouth, blurred vision, constipation).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include dry mouth, blurred vision, pupil dilation, dizziness, nausea, vomiting, headache, CNS stimulation (e.g., confusion, excitement, hallucinations), and tachycardia. Treatment is supportive and symptomatic; activated charcoal may be considered if taken recently.
Pregnancy & Lactation
Pregnancy: Use with caution during pregnancy; consult a doctor. Lactation: Excreted in breast milk, use is generally not recommended during lactation due to potential for anticholinergic effects in the infant.
Side Effects
Contraindications
- Glaucoma
- Obstructive uropathy (e.g., prostatic hypertrophy)
- Gastrointestinal obstruction
- Paralytic ileus
- Severe ulcerative colitis or toxic megacolon
- Myasthenia gravis
- Infants under 6 months
Drug Interactions
Digoxin
May increase serum digoxin levels due to delayed gastric emptying.
Antacids
May decrease the absorption of Dicycloverine. Separate administration by at least 2 hours.
Other Anticholinergics (e.g., tricyclic antidepressants, antihistamines)
Increased risk of anticholinergic side effects (e.g., dry mouth, blurred vision, constipation).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include dry mouth, blurred vision, pupil dilation, dizziness, nausea, vomiting, headache, CNS stimulation (e.g., confusion, excitement, hallucinations), and tachycardia. Treatment is supportive and symptomatic; activated charcoal may be considered if taken recently.
Pregnancy & Lactation
Pregnancy: Use with caution during pregnancy; consult a doctor. Lactation: Excreted in breast milk, use is generally not recommended during lactation due to potential for anticholinergic effects in the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies
Approval Status
Approved
Patent Status
Generic
Clinical Trials
Dicycloverine has been extensively studied in clinical trials for its efficacy in the symptomatic treatment of irritable bowel syndrome (IBS) and other functional bowel disorders.
Lab Monitoring
- No routine lab monitoring is generally required. Monitor for clinical response and adverse effects.
Doctor Notes
- Counsel patients on potential anticholinergic side effects, particularly in the elderly and those with pre-existing conditions (e.g., glaucoma, prostatic hypertrophy).
- Emphasize that this medication manages symptoms and does not cure the underlying condition of IBS.
- Advise patients to report any unusual symptoms like severe constipation or worsening abdominal pain.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid alcohol while taking this medicine as it can increase drowsiness.
- Report any severe or persistent side effects to your doctor.
- Do not stop taking the medicine abruptly without consulting your doctor.
Missed Dose Advice
Take the missed dose as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
May cause dizziness, blurred vision, or drowsiness. Avoid driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain a balanced diet rich in fiber to help manage IBS symptoms.
- Manage stress through relaxation techniques as stress can exacerbate IBS.
- Stay hydrated by drinking plenty of water.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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