Robic
Generic Name
Rabeprazole Sodium
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| robic 500 mg tablet | ৳ 7.02 | ৳ 42.12 |
Description
Overview of the medicine
Robic (Rabeprazole Sodium) is a proton pump inhibitor used to treat conditions where the stomach produces too much acid. It works by reducing the amount of acid produced in the stomach.
Uses & Indications
Dosage
Adults
Duodenal ulcer: 20 mg once daily for 4-8 weeks. Gastric ulcer: 20 mg once daily for 6-12 weeks. GERD: 20 mg once daily for 4-8 weeks. Zollinger-Ellison Syndrome: Initial 60 mg once daily, adjusted as needed.
Elderly
No dose adjustment generally required, but caution with severe hepatic impairment.
Renal_impairment
No dose adjustment required for mild to moderate renal impairment.
How to Take
Taken orally, usually once daily in the morning before breakfast. Tablets should be swallowed whole and not chewed or crushed.
Mechanism of Action
Rabeprazole inhibits the gastric H+, K+-ATPase (proton pump) at the secretory surface of the parietal cells. This blocks the final step of acid secretion, leading to a profound and prolonged inhibition of gastric acid secretion.
Pharmacokinetics
Onset
Within 1 hour, peak effect within 2-4 hours
Excretion
Primarily excreted in urine (approximately 90%) as metabolites, with a small portion in feces
Half life
Approximately 1-2 hours
Absorption
Rapidly absorbed after oral administration, bioavailability about 52%
Metabolism
Extensively metabolized in the liver by cytochrome P450 (CYP2C19 and CYP3A4)
Side Effects
Contraindications
- Hypersensitivity to Rabeprazole, substituted benzimidazoles, or any component of the formulation.
- Children under 12 years (for some indications)
Drug Interactions
Warfarin
Increased INR and prothrombin time reported with concomitant use of PPIs and warfarin.
Methotrexate
Increased plasma levels of methotrexate when given with PPIs.
Drugs requiring acidic gastric pH for absorption (e.g., ketoconazole, itraconazole)
Rabeprazole can decrease their absorption.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. Symptoms may include drowsiness, tachycardia, headache, and nausea. Management is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed. Lactation: Unknown if excreted in human milk, caution advised.
Side Effects
Contraindications
- Hypersensitivity to Rabeprazole, substituted benzimidazoles, or any component of the formulation.
- Children under 12 years (for some indications)
Drug Interactions
Warfarin
Increased INR and prothrombin time reported with concomitant use of PPIs and warfarin.
Methotrexate
Increased plasma levels of methotrexate when given with PPIs.
Drugs requiring acidic gastric pH for absorption (e.g., ketoconazole, itraconazole)
Rabeprazole can decrease their absorption.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. Symptoms may include drowsiness, tachycardia, headache, and nausea. Management is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed. Lactation: Unknown if excreted in human milk, caution advised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Available in pharmacies nationwide
Approval Status
Approved by major regulatory bodies globally, including DGDA (Bangladesh)
Patent Status
Generic versions available, original patent expired
Clinical Trials
Extensive clinical trials support its efficacy and safety in various acid-related disorders.
Lab Monitoring
- No routine lab monitoring typically required for short-term use. For long-term use, magnesium levels may be monitored.
- Liver function tests in patients with hepatic impairment.
Doctor Notes
- Consider alternative diagnosis in patients not responding to therapy.
- Counsel patients on potential long-term risks.
- Monitor for hypomagnesemia in patients on prolonged therapy.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not stop taking the medicine abruptly.
- Report any severe or persistent side effects to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances in some patients, caution advised when driving or operating machinery.
Lifestyle Advice
- Avoid spicy and fatty foods.
- Elevate the head of your bed if experiencing nighttime reflux.
- Quit smoking and reduce alcohol intake.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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