Roket
Generic Name
Cyclobenzaprine Hydrochloride
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| roket 10 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Roket 10 mg Tablet contains Cyclobenzaprine Hydrochloride, a centrally acting skeletal muscle relaxant. It is used for the relief of muscle spasm associated with acute, painful musculoskeletal conditions as an adjunct to rest and physical therapy.
Uses & Indications
Dosage
Adults
The usual dose is 5 mg three times a day. Based on individual patient response, the dose may be increased to 10 mg three times a day. Doses should not exceed 30 mg/day for more than 2-3 weeks.
Elderly
Use with caution. Start with 5 mg once a day, gradually increasing to 5 mg two or three times a day if needed. Not recommended in patients 65 years or older due to increased risk of side effects.
Renal_impairment
No specific dosage adjustment provided, but use with caution due to potential accumulation of metabolites. Not recommended in severe renal impairment.
How to Take
Take orally with or without food. Do not crush, chew, or break the tablet; swallow whole.
Mechanism of Action
Cyclobenzaprine acts on the brainstem and spinal cord to reduce tonic somatic motor activity. It is structurally related to tricyclic antidepressants and its action is believed to be mediated by effects on the norepinephrine and serotonin systems.
Pharmacokinetics
Onset
Approximately 1 hour
Excretion
Mainly excreted via the kidneys as metabolites. Some excretion via feces.
Half life
18 hours (range 8-37 hours)
Absorption
Well absorbed from the gastrointestinal tract. Peak plasma concentrations are reached in about 1.5 to 8 hours.
Metabolism
Extensively metabolized in the liver, primarily by N-demethylation and conjugation, followed by excretion of glucuronide conjugates.
Side Effects
Contraindications
- Hypersensitivity to cyclobenzaprine or any component of the formulation.
- Concomitant use of monoamine oxidase (MAO) inhibitors or within 14 days after their discontinuation.
- Hyperthyroidism.
- Heart failure, arrhythmias, heart block or conduction disturbances, or acute recovery phase of myocardial infarction.
Drug Interactions
Tramadol
Increased risk of seizures and serotonin syndrome.
SSRI/SNRI
Increased risk of serotonin syndrome.
MAO Inhibitors
Increased risk of serotonin syndrome, hypertensive crisis. Concomitant use is contraindicated.
Anticholinergic Agents
Potentiated anticholinergic effects, increased risk of adverse reactions such as urinary retention, paralytic ileus, blurred vision.
CNS Depressants (alcohol, barbiturates, benzodiazepines)
Increased CNS depressant effects.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, tachycardia, tremor, agitation, vomiting, hallucinations, and coma. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered in severe cases.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk; avoid use during lactation due to potential for serious adverse reactions in the infant.
Side Effects
Contraindications
- Hypersensitivity to cyclobenzaprine or any component of the formulation.
- Concomitant use of monoamine oxidase (MAO) inhibitors or within 14 days after their discontinuation.
- Hyperthyroidism.
- Heart failure, arrhythmias, heart block or conduction disturbances, or acute recovery phase of myocardial infarction.
Drug Interactions
Tramadol
Increased risk of seizures and serotonin syndrome.
SSRI/SNRI
Increased risk of serotonin syndrome.
MAO Inhibitors
Increased risk of serotonin syndrome, hypertensive crisis. Concomitant use is contraindicated.
Anticholinergic Agents
Potentiated anticholinergic effects, increased risk of adverse reactions such as urinary retention, paralytic ileus, blurred vision.
CNS Depressants (alcohol, barbiturates, benzodiazepines)
Increased CNS depressant effects.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, tachycardia, tremor, agitation, vomiting, hallucinations, and coma. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered in severe cases.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk; avoid use during lactation due to potential for serious adverse reactions in the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies nationwide
Approval Status
Approved by FDA/DGDA
Patent Status
Expired
Clinical Trials
Extensive clinical trials have established the efficacy and safety of cyclobenzaprine for short-term relief (up to 2-3 weeks) of muscle spasm associated with acute, painful musculoskeletal conditions.
Lab Monitoring
- No specific routine lab monitoring is required. Liver function tests may be considered in patients with hepatic impairment or during prolonged use.
Doctor Notes
- Prescribe for short-term use only (2-3 weeks) for acute muscle spasm.
- Assess for underlying conditions contributing to muscle spasm before prescribing.
- Advise patients about potential for drowsiness, dizziness, and avoidance of alcohol or other CNS depressants.
- Caution in elderly patients and those with cardiac conditions or hyperthyroidism.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor, usually for a short period (2-3 weeks).
- Do not drive or operate heavy machinery until you know how this medicine affects you due to potential drowsiness.
- Avoid alcohol and other CNS depressants while taking this medicine.
- Inform your doctor about all other medications, including over-the-counter drugs and herbal supplements, you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause drowsiness or dizziness. Patients should be warned about engaging in hazardous activities requiring mental alertness, such as operating machinery or driving a motor vehicle, until they are reasonably certain that the drug does not adversely affect them.
Lifestyle Advice
- Combine with rest and physical therapy for best results in managing muscle spasms.
- Maintain good posture and ergonomic practices to prevent recurrence of muscle pain.
- Engage in gentle stretching exercises as advised by a physical therapist once acute spasms subside.
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