Roket
Generic Name
Ketorolac Tromethamine
Manufacturer
Eskayef Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| roket 30 mg injection | ৳ 55.00 | N/A |
Description
Overview of the medicine
Roket 30 mg Injection is a potent non-steroidal anti-inflammatory drug (NSAID) used for short-term management of moderate to severe acute pain. It works by reducing hormones that cause pain and inflammation in the body.
Uses & Indications
Dosage
Adults
30 mg IM or IV every 6 hours, not to exceed 120 mg/day for a maximum of 5 days.
Elderly
Reduced dosage, typically 15 mg IM or IV every 6 hours, not to exceed 60 mg/day for a maximum of 5 days.
Renal_impairment
Significantly reduced dosage; contraindicated in severe renal impairment. For mild to moderate, typically 15 mg IM or IV every 6 hours, not to exceed 60 mg/day.
How to Take
Administer intramuscularly (IM) slowly and deeply into a large muscle mass, or intravenously (IV) slowly over at least 15 seconds. Ensure patient is well hydrated.
Mechanism of Action
Ketorolac inhibits prostaglandin synthesis by reversibly inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes. This leads to a reduction in inflammation, pain, and fever.
Pharmacokinetics
Onset
Analgesic effect typically begins within 30 minutes, with peak effect in 1-2 hours.
Excretion
Primarily renal (approximately 90%), with some fecal excretion (approximately 6%).
Half life
Approximately 4-6 hours (ranges from 2.5 to 9 hours depending on age and renal function).
Absorption
Rapidly and completely absorbed after intramuscular (IM) administration. Peak plasma concentrations are reached within 30-50 minutes.
Metabolism
Primarily hepatic, through hydroxylation and conjugation.
Side Effects
Contraindications
- Hypersensitivity to ketorolac or other NSAIDs
- Active peptic ulcer, gastrointestinal bleeding or perforation
- Advanced renal impairment
- Coagulopathy or patients at high risk of bleeding
- As prophylactic analgesic before major surgery or intra-operatively
- During labor and delivery
- Children under 2 years (usually not recommended for children due to lack of data and risk of adverse effects)
Drug Interactions
Lithium
Increased lithium plasma levels and toxicity.
Diuretics
Reduced natriuretic effect.
Methotrexate
Increased methotrexate toxicity.
Other NSAIDs
Increased risk of GI adverse events.
ACE inhibitors/ARBs
Decreased antihypertensive effect and increased risk of renal impairment.
Warfarin/Anticoagulants
Increased risk of bleeding.
Storage
Store at controlled room temperature (20°C to 25°C), excursions permitted to 15°C to 30°C. Protect from light. Do not freeze.
Overdose
Symptoms may include abdominal pain, nausea, vomiting, lethargy, drowsiness, and in rare cases, GI bleeding, acute renal failure, and respiratory depression. Management is primarily supportive. Gastric decontamination (e.g., activated charcoal) may be considered if recent oral ingestion, but not applicable for injection overdose. Monitor renal function and provide symptomatic treatment.
Pregnancy & Lactation
Pregnancy: Category C in early pregnancy, Category D in third trimester (increased risk of premature closure of fetal ductus arteriosus). Avoid use in late pregnancy. Lactation: Small amounts excreted in breast milk. Use with caution or avoid during breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to ketorolac or other NSAIDs
- Active peptic ulcer, gastrointestinal bleeding or perforation
- Advanced renal impairment
- Coagulopathy or patients at high risk of bleeding
- As prophylactic analgesic before major surgery or intra-operatively
- During labor and delivery
- Children under 2 years (usually not recommended for children due to lack of data and risk of adverse effects)
Drug Interactions
Lithium
Increased lithium plasma levels and toxicity.
Diuretics
Reduced natriuretic effect.
Methotrexate
Increased methotrexate toxicity.
Other NSAIDs
Increased risk of GI adverse events.
ACE inhibitors/ARBs
Decreased antihypertensive effect and increased risk of renal impairment.
Warfarin/Anticoagulants
Increased risk of bleeding.
Storage
Store at controlled room temperature (20°C to 25°C), excursions permitted to 15°C to 30°C. Protect from light. Do not freeze.
Overdose
Symptoms may include abdominal pain, nausea, vomiting, lethargy, drowsiness, and in rare cases, GI bleeding, acute renal failure, and respiratory depression. Management is primarily supportive. Gastric decontamination (e.g., activated charcoal) may be considered if recent oral ingestion, but not applicable for injection overdose. Monitor renal function and provide symptomatic treatment.
Pregnancy & Lactation
Pregnancy: Category C in early pregnancy, Category D in third trimester (increased risk of premature closure of fetal ductus arteriosus). Avoid use in late pregnancy. Lactation: Small amounts excreted in breast milk. Use with caution or avoid during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date when stored correctly.
Availability
Hospitals, Clinics, Pharmacies
Approval Status
Approved by FDA/DGDA
Patent Status
Generic available, patents expired for Ketorolac
WHO Essential Medicine
YesClinical Trials
Ketorolac has undergone extensive clinical trials demonstrating its efficacy in acute pain management, showing comparable analgesic effects to morphine without opioid-related side effects, particularly for short-term post-operative pain.
Lab Monitoring
- Renal function (creatinine, BUN)
- Liver function (ALT, AST)
- Complete Blood Count (CBC) with differential, especially if prolonged use
- Coagulation parameters (INR, PT/aPTT)
Doctor Notes
- Limit use to 5 days due to increased risk of serious adverse events.
- Assess renal function before initiating treatment, especially in elderly or patients with pre-existing renal impairment.
- Monitor for signs of GI bleeding and cardiovascular events.
Patient Guidelines
- Inform your doctor about all current medications, including over-the-counter drugs and herbal supplements.
- Report any signs of unusual bleeding, dark stools, or severe abdominal pain immediately.
- Do not use for more than 5 days to reduce the risk of serious side effects.
- Avoid alcohol while on this medication.
Missed Dose Advice
Since this is an injection administered by a healthcare professional, a missed dose is unlikely. If a scheduled dose is missed, inform your doctor or nurse to reschedule. Do not take a double dose.
Driving Precautions
May cause drowsiness, dizziness, or visual disturbances. Patients should be cautioned against driving or operating machinery if these effects occur.
Lifestyle Advice
- Stay well hydrated.
- Avoid strenuous activities if feeling dizzy or drowsy.
- Follow your doctor's instructions for pain management and consider non-pharmacological methods if appropriate.
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Global Brand Names
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